Effect of chromosomal position on amplification of transfected genes in animal cells

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.

1979 • 3,525 citations

THE STABILITY OF BROKEN ENDS OF CHROMOSOMES IN ZEA MAYS

1941 • 1,586 citations

DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.

1979 • 1,339 citations

TRANSPOSABLE ELEMENTS IN PROKARYOTES

1981 • 765 citations

Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma.

1983 • 764 citations

The role of gene dosage and genetic transpositions in carcinogenesis

1981 • 670 citations

onc gene amplification in promyelocytic leukaemia cell line HL-60 and primary leukaemic cells of the same patient

1982 • 638 citations

A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells

1983 • 485 citations

Gene amplification causes overproduction of the first three enzymes of UMP synthesis in N-(phosphonacetyl)-L-aspartate-resistant hamster cells.

1979 • 484 citations

Unequal crossing over in the ribosomal DNA of Saccharomyces cerevisiae

1980 • 426 citations

Patterns of Integration of DNA Microinjected into Cultured Mammalian Cells: Evidence for Homologous Recombination Between Injected Plasmid DNA Molecules

1982 • 417 citations

Metaphase Chromosome Anomaly: Association with Drug Resistance and Cell-Specific Products

1976 • 396 citations

Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line.

1978 • 393 citations

DOUBLE MINUTES AND HOMOGENEOUSLY STAINING REGIONS: Gene Amplification in Mammalian Cells

1982 • 357 citations

Transforming DNA integrates into the host chromosome

1981 • 311 citations

Spontaneous tandem genetic duplications in Salmonella typhimurium arise by unequal recombination between rRNA (rrn) cistrons.

1981 • 293 citations

Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules.

1982 • 281 citations

Stable mutants of mammalian cells that overproduce the first three enzymes of pyrimidine nucleotide biosynthesis

1976 • 228 citations

N-(Phosphonacetyl)-l-Aspartate, a Potent Transition State Analog Inhibitor of Aspartate Transcarbamylase, Blocks Proliferation of Mammalian Cells in Culture

1974 • 217 citations

Studies on Simian Virus 40 Excision from Cellular Chromosomes

1979 • 206 citations

Correlation of dihydrofolate reductase elevation with gene amplification in a homogeneously staining chromosomal region in L5178Y cells.

1979 • 185 citations

Methotrexate-resistant Chinese hamster ovary cells have amplified a 135-kilobase-pair region that includes the dihydrofolate reductase gene.

1981 • 175 citations

REDUNDANT GENES

1975 • 151 citations

Cloned cDNA sequences of the hypoxanthine/guanine phosphoribosyltransferase gene from a mouse neuroblastoma cell line found to have amplified genomic sequences.

1982 • 136 citations

Homologous recombination in mammalian cells mediates formation of a functional gene from two overlapping gene fragments.

1983 • 129 citations

A structure for amplified DNA

1983 • 127 citations

The cloning and reintroduction into animal cells of a functional CAD gene, a dominant amplifiable genetic marker

1981 • 104 citations

Evolution of chromosomal regions containing transfected and amplified dihydrofolate reductase sequences.

1983 • 96 citations

Single-copy and amplified CAD genes in Syrian hamster chromosomes localized by a highly sensitive method for in situ hybridization.

1982 • 91 citations

Specifically altered metaphase chromosomes in antifolate-resistant Chinese hamster cells that overproduce dihydrofolate reductase

1980 • 88 citations

Biochemical genetic analysis of pyrimidine biosynthesis in mammalian cells: I. Isolation of a mutant defective in the early steps of de novo pyrimidine synthesis

1977 • 78 citations

Satellite DNA in large marker chromosomes of methotrexate-resistant mouse cells

1980 • 72 citations

Structure of the Gene for CAD, the Multifunctional Protein That Initiates UMP Synthesis in Syrian Hamster Cells

1982 • 69 citations

A chromosome inversion alters the pattern of specific DNA replication in drosophila follicle cells

1981 • 66 citations

Amplification and rearrangement of integrated SV40 DNA sequences accompany the selection of anchorage-independent transformed mouse cells

1980 • 59 citations

Cloning of DNA from double minutes of Y1 mouse adrenocortical tumor cells: Evidence for gene amplification

1981 • 56 citations

Molecular analysis of large transposable elements carrying the white locus of Drosophila melanogaster

1983 • 53 citations

Amplification of integrated viral DNA sequences in polyoma virus-transformed cells.

1980 • 43 citations

Structure of the gene for CAD, the multifunctional protein that initiates UMP synthesis in Syrian hamster cells.

1982 • 42 citations

Chromosomal Alterations Associated with Overproduction of Asparagine Synthetase in Albizziin-Resistant Chinese Hamster Ovary Cells

1983 • 35 citations

Chromosomal alterations associated with overproduction of asparagine synthetase in albizziin-resistant Chinese hamster ovary cells.

1983 • 25 citations

Properties of dispersed, highly repeated DNA within and near the hamster CAD gene.

1982 • 18 citations