Pluripotential liver stem cells: facultative stem cells located in the biliary tree

The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells

1982 • 5,272 citations

Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt

1990 • 1,793 citations

Developmental biology of the pancreas

1995 • 942 citations

TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors.

1994 • 937 citations

A morphologic study of deoxyribonucleic acid synthesis and cell proliferation in regenerating rat liver; autoradiography with thymidine-H3.

1962 • 773 citations

Similarities in the sequence of early histological changes induced in the liver of the rat by ethionine, 2-acetylamino-fluorene, and 3'-methyl-4-dimethylaminoazobenzene.

1956 • 670 citations

Liver regeneration. 2. Role of growth factors and cytokines in hepatic regeneration.

1995 • 613 citations

Induction of a novel epidermal growth factor-secreting cell lineage by mucosal ulceration in human gastrointestinal stem cells

1990 • 465 citations

A precursor—product relationship exists between oval cells and hepatocytes in rat liver

1987 • 448 citations

Cell lineages and oval cell progenitors in rat liver development.

1991 • 391 citations

A diploid epithelial cell line from normal adult rat liver with phenotypic properties of ?oval? cells*1

1984 • 381 citations

Maturation arrest of stem cell differentiation is a common pathway for the cellular origin of teratocarcinomas and epithelial cancers.

1994 • 378 citations

An epithelial scatter factor released by embryo fibroblasts

1985 • 368 citations

Embryonic RNA expression patterns of the c-kit receptor and its cognate ligand suggest multiple functional roles in mouse development.

1991 • 346 citations

Modulation of alpha smooth muscle actin and desmin expression in perisinusoidal cells of normal and diseased human livers.

1991 • 334 citations

The extracellular matrix in hepatic regeneration

1995 • 325 citations

In vivo differentiation of rat liver oval cells into hepatocytes.

1989 • 318 citations

Oval cell proliferation and the origin of small hepatocytes in liver injury induced by D-galactosamine.

1991 • 309 citations

The development of the intrahepatic bile ducts in man: A keratin-immunohistochemical study

1988 • 309 citations

Is there a liver stem cell?

1990 • 304 citations

Hepatocyte growth factor/scatter factor induces a variety of tissue-specific morphogenic programs in epithelial cells.

1995 • 301 citations

Presence of hematopoietic stem cells in the adult liver

1996 • 300 citations

Evidence for the stem cell origin of hepatocellular carcinoma and cholangiocarcinoma.

1989 • 294 citations

THE KINETICS OF CELLULAR PROLIFERATION IN REGENERATING LIVER

1968 • 288 citations

Expression of stem cell factor and its receptor, c-kit, during liver regeneration from putative stem cells in adult rat.

1994 • 285 citations

Hepatoid adenocarcinomas of the stomach: An analysis of seven cases

1986 • 282 citations

Scatter factor and the c-met receptor: a paradigm for mesenchymal/epithelial interaction.

1994 • 279 citations

The streaming liver

1985 • 271 citations

Transforming growth factors beta 1 and beta 2 are differentially expressed in fibrotic liver disease.

1991 • 266 citations

The Biology of Epithelial Cell Populations

1985 • 246 citations

Activation, proliferation, and differentiation of progenitor cells into hepatocytes in the D-galactosamine model of liver regeneration.

1993 • 246 citations

The liver as a stem cell and lineage system

1992 • 237 citations

Expression of hepatic transcription factors during liver development and oval cell differentiation.

1994 • 230 citations

Biliary epithelial and hepatocytic cell lineage relationships in embryonic rat liver as determined by the differential expression of cytokeratins, alpha-fetoprotein, albumin, and cell surface-exposed components.

1988 • 213 citations

Hepatocyte growth factor/hepatopoietin A is expressed in fat-storing cells from rat liver but not myofibroblast-like cells derived from fat-storing cells

1992 • 212 citations

Oxford Textbook of Pathology

1994 • 210 citations

Native and recombinant human hepatocyte growth factors are highly potent promoters of DNA synthesis in both human and rat hepatocytes.

1991 • 202 citations

Cellular origin of cancer: dedifferentiation or stem cell maturation arrest?

1993 • 196 citations

Occurrence of oval-type cells in hepatitis B virus—associated human hepatocarcinogenesis

1992 • 195 citations

Regulation of the differentiation of diploid and some aneuploid rat liver epithelial (stemlike) cells by the hepatic microenvironment.

1993 • 185 citations

Role of cholangioles in restoration of the liver of the mouse after dietary injury

1958 • 185 citations

Lipocytes from normal rat liver release a neutral metalloproteinase that degrades basement membrane (type IV) collagen.

1989 • 177 citations

Regulation of hepatic growth

1986 • 173 citations

Origin and fate of oval cells in dipin-induced hepatocarcinogenesis in the mouse.

1994 • 168 citations

THE PATHOGENESIS OF TUMORS OF THE LIVER PRODUCED BY BUTTER YELLOW

1944 • 158 citations

Expression of hepatocyte growth factor and c-met genes during hepatic differentiation and liver development in the rat.

1993 • 155 citations

Oval cell differentiation into hepatocytes in the acetylaminofluorene-treated regenerating rat liver*1

1995 • 155 citations

Cell lineage study in the liver using retroviral mediated gene transfer. Evidence against the streaming of hepatocytes in normal liver.

1994 • 145 citations

Hepatocarcinomas, cholangiocarcinomas, and hepatoblastomas produced by chemically transformed cultured rat liver epithelial cells. A light- and electron-microscopic analysis.

1987 • 143 citations

Promotion of growth and differentiation of rat ductular oval cells in primary culture.

1988 • 142 citations

Human intrahepatic biliary epithelial cells proliferate in vitro in response to human hepatocyte growth factor.

1992 • 141 citations

Isolation, Culture, and Transplantation of Intrahepatic Biliary Epithelial Cells and Oval Cells

1990 • 141 citations

Expression of c-Ki-ras, c-Ha-ras, and c-myc in specific cell types during hepatocarcinogenesis.

1985 • 140 citations

Experimental coexpression of vimentin and keratin intermediate filaments in human melanoma cells augments motility.

1996 • 138 citations

Synergy between hepatitis B virus expression and chemical hepatocarcinogens in transgenic mice.

1991 • 133 citations

Differential tubulogenic and branching morphogenetic activities of growth factors: implications for epithelial tissue development.

1995 • 133 citations

Hepatocyte growth factor induces proliferation and differentiation of multipotent and erythroid hemopoietic progenitors.

1994 • 131 citations

Role of periductal and ductular epithelial cells of the adult rat pancreas in pancreatic hepatocyte lineage. A change in the differentiation commitment.

1989 • 130 citations

Studies on the Fine Structure of the Terminal Branches of the Biliary Tree: I. The Morphology of Normal Bile Canaliculi, Bile Pre-ductules (Ducts of Hering) and Bile Ductules.

1961 • 130 citations

Origin and fate of proliferated hepatic ductal cells in the rat: Electron microscopic and autoradiographic studies

1964 • 128 citations

A cytokeratin immunohistochemical study of cholestatic liver disease: Evidence that hepatocytes can express “bile duct‐type” cytokeratins

1989 • 128 citations

Ultrastructural characteristics of novel epithelial cell types identified in human pathologic liver specimens with chronic ductular reaction.

1992 • 122 citations

Liver damage in the rat induces hepatocyte stem cells from biliary epithelial cells

1996 • 120 citations

Expression of transforming growth factor‐alpha in regenerating liver and during hepatic differentiation

1992 • 114 citations

Macrophage and perisinusoidal cell kinetics in acute liver injury

1992 • 113 citations

Cell adhesion molecules in liver function and pattern formation

1994 • 113 citations

Light- and electron-microscopic autoradiographic analysis of proliferating cells during the early stages of chemical hepatocarcinogenesis in the rat induced by feeding N-2-fluorenylacetamide in a choline-deficient diet.

1984 • 105 citations

Hepatic Stem Cell Compartment: Activation and Lineage Commitment

1993 • 104 citations

Intestinal metaplasia as a common option of oval cells in relation to cholangiofibrosis in liver of rats exposed to 2-acetylaminofluorene.

1985 • 101 citations

Cell lineages and differentiation programs in epidermal, urothelial and hepatic tissues and their neoplasms.

1990 • 98 citations

Development of human intrahepatic peribiliary glands. Histological, keratin immunohistochemical, and mucus histochemical analyses.

1993 • 97 citations

Wright??s Liver and Biliary Disease

1994 • 97 citations

Isozyme profiles of oval cells, parenchymal cells, and biliary cells isolated by centrifugal elutriation from normal and preneoplastic livers.

1984 • 94 citations

Cellular and molecular changes in the early stages of chemical hepatocarcinogenesis in the rat.

1990 • 93 citations

Histogenesis of bile duct-like cells proliferating during ethionine hepatocarcinogenesis. Evidence for a biliary epithelial nature of oval cells.

1992 • 93 citations

Common antigens of mouse oval and biliary epithelial cells. Expression on newly formed hepatocytes

1990 • 93 citations

Expression of acidic fibroblast growth factor in regenerating liver and during hepatic differentiation.

1992 • 88 citations

Hepatoid adenocarcinoma of the renal pelvis producing alpha-fetoprotein of hepatic type and bile pigment

1991 • 87 citations

Experiments in transgenic mice show that hepatocytes are the source for postnatal liver growth and do not stream

1995 • 87 citations

Phenotypic characterization of metaplastic intestinal glands and ductular hepatocytes in cholangiofibrotic lesions rapidly induced in the caudate liver lobe of rats treated with furan.

1991 • 87 citations

The stem cells of the liver ? a selective review

1992 • 85 citations

Cell Lineages in Hepatic Development and the Identification of Progenitor Cells in Normal and Injured Liver

1993 • 85 citations

Cell behavior in the acetylaminofluorene-treated regenerating rat liver. Light and electron microscopic observations.

1994 • 84 citations

The Nature and Origin of Proliferated Bile Ductules in Alcoholic Liver Disease

1983 • 84 citations

Participation of small intraportal stem cells in the restitutive response of the liver to periportal necrosis induced by allyl alcohol

1995 • 79 citations

Hepatic Progenitor Populations in Embryonic, Neonatal, and Adult Liver

1993 • 78 citations

Small epithelial cells and the histogenesis of hepatoblastoma. Electron microscopic, immunoelectron microscopic, and immunohistochemical findings.

1996 • 75 citations

Isolation Culture, and Transplantation of Rat Hepatocytic Precursor (Stem-like) Cells

1993 • 75 citations

Modulation of keratin 14 and α‐fetoprotein expression during hepatic oval cell proliferation and liver regeneration

1994 • 75 citations

Immunolocalization of regenerating cells after submassive liver necrosis using PCNA staining

1992 • 73 citations

Proliferation, apoptosis, and induction of hepatic transcription factors are characteristics of the early response of biliary epithelial (oval) cells to chemical carcinogens

1996 • 73 citations

The role of determined stem-cells in the cellular lineage of hepatocellular carcinoma.

1993 • 72 citations

Differential cytokeratin and alpha-fetoprotein expression in morphologically distinct epithelial cells emerging at the early stage of rat hepatocarcinogenesis.

1985 • 72 citations

"Intestinal-type" of adenocarcinoma preferentially induced in right/caudate liver lobes of rats treated with furan.

1993 • 72 citations

A cytokeratin immunohistochemical study of alcoholic liver disease: evidence that hepatocytes can express ‘bile duct‐type’ cytokeratins

1988 • 70 citations

Distribution and origin of the basement membrane component perlecan in rat liver and primary hepatocyte culture.

1993 • 69 citations

Evidence for a common cell of origin for primitive epithelial cells isolated from rat liver and pancreas

1991 • 68 citations

Models for Hepatic Progenitor Cell Activation

1993 • 68 citations

Multiple alpha-fetoprotein RNAs in adult rat liver: cell type-specific expression and differential regulation.

1991 • 65 citations

Characterization of ductular hepatocytes in end-stage cirrhosis.

1990 • 65 citations

Expression of matrix proteinases during human intrahepatic bile duct development. A possible role in biliary cell migration.

1995 • 64 citations

Bile duct changes in alcoholic liver disease

1993 • 64 citations

Oval cell lines OC/CDE 6 and OC/CDE 22 give rise to cholangio-cellular and undifferentiated carcinomas after transformation.

1994 • 64 citations

Differentiation of oval cells into duct-like cells in preneoplastic liver of rats placed on a choline-deficient diet supplemented with ethionine

1994 • 62 citations

Reactive human bile ductules express parathyroid hormone‐related peptide

1993 • 61 citations

Connection of ductlike structures induced by a chemical hepatocarcinogen to portal bile ducts in the rat liver detected by injection of bile ducts with a pigmented barium gelatin medium.

1985 • 61 citations

Role of TGF‐Beta in Normal Differentiation and Oncogenesis in Rat Liver

1989 • 61 citations

Development of intrahepatic bile ducts in humans. Possible role of laminin.

1990 • 59 citations

Distribution of albumin and alpha-fetoprotein mRNAs in normal, hyperplastic, and preneoplastic rat liver.

1992 • 59 citations

Rapid development of large numbers of alpha-fetoprotein-containing "oval" cells in the liver of rats fed N-2-fluorenylacetamide in a choline-devoid diet.

1981 • 58 citations

Appearance of oval cells in the liver of rats after long-term exposure to ethanol

1996 • 58 citations

Endocrine cells in the intrahepatic biliary tree in normal livers and hepatolithiasis.

1989 • 58 citations

Enzyme profile of rat bile ductular epithelial cells in reference to the resistance phenotype in hepatocarcinogenesis

1989 • 57 citations

Parathyroid hormone‐related peptide expression in primary and metastatic liver tumours

1993 • 56 citations

α‐FETOPROTEIN AND EARLY HISTOLOGICAL CHANGES OF HEPATIC TISSUE IN DAB‐HEPATOCARCINOGENESIS*

1975 • 55 citations

Characterizations of and interactions between bile ductule cells and hepatocytes in early stages of rat hepatocarcinogenesis induced by ethionine.

1991 • 54 citations

Expression of hepatocyte growth factor mRNA during oval cell activation in the rat liver

1993 • 52 citations

Bile duct proliferation—its true significance?

1993 • 51 citations

Migration of hepatocytes along hepatic plates and stem cell-fed hepatocyte lineages.

1994 • 49 citations

Ultrastructural localisation of alpha-fetoprotin (AFP) in regenerating mouse liver poisoned with CCL4

1984 • 49 citations

Phenotypic and karyotypic changes induced in cultured rat hepatic epithelial cells that express the "oval" cell phenotype by exposure to N-methyl-N'-nitro-N-nitrosoguanidine.

1985 • 48 citations

Ductular hepatocytes. Evidence for a bile ductular cell origin in furan-treated rats.

1994 • 48 citations

Specialization Switch in Differentiating Embryonic Rat Liver Progenitor Cells in Response to Sodium Butyrate

1995 • 47 citations

Comparison of oval cells induced in rat liver by feeding N-2-fluorenylacetamide in a choline-devoid diet and bile duct cells induced by feeding 4,4'-diaminodiphenylmethane.

1983 • 47 citations

Cells with neuroendocrine features in regenerating human liver

1991 • 46 citations

Malignant cells of epithelial phenotype limited to thoracic lymph nodes

1990 • 46 citations

Neoplastic transformation and lineage switching of rat liver epithelial cells by retrovirus‐associated oncogenes

1988 • 45 citations

The resistant hepatocyte model of carcinogenesis in the rat: the apparent independent development of oval cell proliferation and early nodules

1995 • 44 citations

Vimentin expression of newly formed rat bile duct epithelial cells in secondary biliary fibrosis

1989 • 41 citations

Intrahepatic distribution of transforming growth factor‐alpha (TGFα) during liver regeneration following carbon tetrachlorideinduced necrosis

1993 • 40 citations

Characterization of biliary epithelial cells isolated from needle biopsies of human liver in the presence of hepatocyte growth factor.

1995 • 39 citations

Epithelial-mesenchymal transition in cultured neonatal hepatocytes

1995 • 38 citations

Cytokeratin 14 expression in rat liver cells in culture and localization in vivo

1992 • 38 citations

Oval cell differentiation into hepatocytes in the acetylaminofluorene-treated regenerating rat liver

1995 • 36 citations

Combined choriocarcinoma, hepatoid adenocarcinoma, small cell carcinoma and tubular adenocarcinoma in the oesophagus

1995 • 35 citations

Sequential appearance of intestinal mucosal cell types in the right and caudate liver lobes of furan-treated rats

1992 • 35 citations

Epithelial cell lineages in developing, restoring, and transforming liver: evidence for the existence of a 'differentiation window'.

1994 • 34 citations

Oval cells — hepatocytes relationships in Dipin-induced hepatocarcinogenesis in mice

1993 • 33 citations

Phenotypic Heterogeneity within Clonogenic Ductal Cell Populations Isolated from Normal Adult Rat Liver

1993 • 32 citations

Alpha fetoprotein-producing acinar cell carcinoma of the pancreas showing multiple lines of differentiation

1995 • 32 citations

Short–term diethylnitrosamine–induced oval cell responses in three strains of mice

1994 • 32 citations

Sequential analysis of hepatic carcinogenesis. Regeneration of liver after carbon tetrachloride-induced liver necrosis when hepatocyte proliferation is inhibited by 2-acetylaminofluorene.

1983 • 30 citations

Enhanced susceptibility to a chemical carcinogen in rats carrying MHC‐linked genes influencing development (GRC)

1984 • 29 citations

Metabolic properties of isolated rat liver cell preparations enriched in epithelial cells other than hepatocytes

1983 • 29 citations

Light microscopic and ultrastructural distribution of type VI collagen in human liver: alterations in chronic biliary disease

1992 • 29 citations

Hepatocytic differentiation of cultured rat pancreatic ductal epithelial cells after in vivo implantation.

1995 • 28 citations

Heterogeneity of alpha-fetoprotein(AFP) and albumin containing cells in normal and pathological permissive states for AFP production: AFP containing cells induced in adult rats recapitulate the appearance of AFP containing hepatocytes in fetal rats.

1980 • 27 citations

Transforming growth factor‐α immunoreactivity in a variety of epithelial tissues

1993 • 27 citations

Three-dimensional arrangement of ductular structures formed by oval cells during hepatocarcinogenesis.

1988 • 26 citations

Appearance of Hepatocytelike Cells in the Interlobular Bile Ducts of Human Liver in Various Liver Disease States

1992 • 26 citations

Reduced DNA adduct formation in replicating liver cells during continuous feeding of a chemical carcinogen.

1990 • 26 citations

Liver carcinogenesis associated with feeding of ethionine in a choline-free diet: evidence against a role of oval cells in the emergence of hepatocellular carcinoma.

1993 • 25 citations

Parathyroid hormone-related peptide is expressed and rapidly inducible in human liver cell cultures that have a bile duct phenotype

1995 • 23 citations

Carcinogen-induced alterations in rat liver DNA adduct formation determined by computerized fluorescent image analysis.

1991 • 23 citations

gamma-Glutamyl transpeptidase in rat liver during 3'-Me-DAB hepatocarcinogenesis: immunohistochemical and enzyme histochemical study.

1987 • 22 citations

Hepatic lipocytes, TIMP-1 and liver fibrosis.

1994 • 22 citations

A fluorescence microscopic study of bile duct proliferation induced in guinea pigs by alpha-naphthyl isothiocyanate.

1969 • 21 citations

Hepatocellular Carcinoma in Extrahepatic Bile Ducts

1991 • 20 citations

Cytokeratin expression in cells of the rodent bile duct developing under normal and pathological conditions.

1989 • 17 citations

Appearance of a Carcinoid–like Pattern in Rat Hepatic Tumors Induced by 3′–Methyl‐4–dimethyl ‐aminoazobenzene

1991 • 14 citations

Carcinogen-induced alterations in rat liver DNA adduct formation determined by computerized fluorescent image analysis.

1991 • 14 citations

Liver-directed gene therapy: molecular tools and current preclinical and clinical studies

1995 • 14 citations

A non-bile duct origin for intestinal crypt-like ducts with periductular fibrosis induced in livers of F344 rats by chloroform inhalation

1996 • 13 citations

A structural analysis of gap and tight junctions in the rat liver during a dietary treatment that induces oval cell proliferation.

1986 • 13 citations

Tissue distribution of liver regulating protein. Evidence for a cell recognition signal common to liver, pancreas, gonads, and hemopoietic tissues.

1994 • 13 citations

Formation of Ductular Structures in Vitro by Rat Pancreatic Epithelial Oval Cells

1993 • 13 citations

Expression of HBs- and HBc-antigen in neoductular epithelium in chronic active hepatitis B

1993 • 11 citations

Ductular structures in acute hepatitis with panacinar necrosis

1995 • 11 citations

Liver carcinogenesis associated with feeding of ethionine in a choline-free diet: Evidence against a role of oval cells in the emergence of hepatocellular carcinoma

1993 • 11 citations

Lipid peroxidation and protein thiol depletion are not involved in the cytotoxicity of N-hydroxy-2-acetylaminofluorene in isolated rat hepatocytes

1990 • 9 citations

Histopathological and ultrastructural study on extramedullary hematopoietic foci in early stage of 3'-methyl-4-(dimethylamino)azobenzene hepatocarcinogenesis.

1978 • 8 citations

Hepatocellular Carcinoma in Extrahepatic Bile Ducts

1991 • 6 citations

Early Hepatic Lesions with Marked Glandular Structures Induced in Rats by 0.1% Ethionine in a Choline Deficient Diet

1993 • 6 citations

Hepatic lesions in Syrian golden hamsters with pancreatic carcinoma induced by N-nitrosobis(2-oxopropyl)amine (BOP).

1990 • 5 citations