Distribution of albumin and alpha-fetoprotein mRNAs in normal, hyperplastic, and preneoplastic rat liver.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Similarities in the sequence of early histological changes induced in the liver of the rat by ethionine, 2-acetylamino-fluorene, and 3'-methyl-4-dimethylaminoazobenzene.

1956 • 670 citations

A precursor—product relationship exists between oval cells and hepatocytes in rat liver

1987 • 448 citations

Intermediate filaments: Cell-type-specific markers in differentiation and pathology

1982 • 331 citations

In vivo differentiation of rat liver oval cells into hepatocytes.

1989 • 318 citations

Biliary physiology in rats with bile ductular cell hyperplasia. Evidence for a secretory function of proliferated bile ductules.

1988 • 314 citations

Evidence for the stem cell origin of hepatocellular carcinoma and cholangiocarcinoma.

1989 • 294 citations

Biochemical and immunological identification of cytokeratin proteins present in hepatocytes of mammalian liver tissue

1981 • 282 citations

Origin, pattern, and mechanism of bile duct proliferation following biliary obstruction in the rat

1990 • 227 citations

Sequence homology between RNAs encoding rat alpha-fetoprotein and rat serum albumin.

1981 • 173 citations

Progressive microscopic alterations in the livers of rats fed the hepatic carcinogens 3'-methyl-4-dimethylaminoazobenzene and 4'-fluoro-4-dimethylaminoazobenzene.

1952 • 168 citations

Keratin immunohistochemistry in normal human liver. Cytokeratin pattern of hepatocytes, bile ducts and acinar gradient

1987 • 157 citations

Experimental cholangitis due to alpha-naphthyl-isothiocyanate (ANIT).

1962 • 157 citations

Intrahepatic bile duct development in the rat: a cytokeratin-immunohistochemical study.

1988 • 149 citations

Expression of c-Ki-ras, c-Ha-ras, and c-myc in specific cell types during hepatocarcinogenesis.

1985 • 140 citations

Ductular cell reaction in the liver in hepatic injury.

1957 • 134 citations

Morphologic identification by electron microscopy of "oval" cells in experimental hepatic degeneration.

1961 • 131 citations

Studies on the Fine Structure of the Terminal Branches of the Biliary Tree: I. The Morphology of Normal Bile Canaliculi, Bile Pre-ductules (Ducts of Hering) and Bile Ductules.

1961 • 130 citations

Growth in culture and tumorigenicity after transfection with the ras oncogene of liver epithelial cells from carcinogen-treated rats.

1987 • 116 citations

Bile secretory function of intrahepatic biliary epithelium in the rat

1989 • 110 citations

Production of hepatocellular carcinoma by oval cells: cell cycle expression of c-myc and p53 at different stages of oval cell transformation.

1989 • 102 citations

The origin of intrahepatic bile duct cells in the mouse.

1984 • 99 citations

Cell lineages and differentiation programs in epidermal, urothelial and hepatic tissues and their neoplasms.

1990 • 98 citations

c-myc gene amplification during hepatocarcinogenesis by a choline-devoid diet.

1989 • 95 citations

Cellular and molecular changes in the early stages of chemical hepatocarcinogenesis in the rat.

1990 • 93 citations

Histogenesis of bile duct-like cells proliferating during ethionine hepatocarcinogenesis. Evidence for a biliary epithelial nature of oval cells.

1992 • 93 citations

In situ hybridization studies on expression of albumin and alpha-fetoprotein during the early stage of neoplastic transformation in rat liver.

1987 • 93 citations

Demonstration of glucose 6-phosphatase activity in the oval cells of rat liver and the significance of the oval cells in azo dye carcinogenesis.

1974 • 86 citations

Cell lineages in liver carcinogenesis: possible clues from studies of the distribution of alpha-fetoprotein RNA sequences in cell populations isolated from normal, regenerating, and preneoplastic rat livers.

1985 • 77 citations

A morphological and histochemical study of carcinogenesis of the liver in rats fed 3'-methyl-4-dimethylaminoazobenzene.

1973 • 68 citations

A choline-devoid diet, carcinogenic in the rat, induces DNA damage and repair

1986 • 66 citations

Multiple alpha-fetoprotein RNAs in adult rat liver: cell type-specific expression and differential regulation.

1991 • 65 citations

Cellular analysis of alpha-fetoprotein gene activation during carbon tetrachloride and D-galactosamine-induced acute liver injury in rats.

1988 • 61 citations

Role of different epithelial cell types in liver ontogenesis, regeneration and neoplasia

1989 • 60 citations

Enzyme profile of rat bile ductular epithelial cells in reference to the resistance phenotype in hepatocarcinogenesis

1989 • 57 citations

Isolation of a nonparenchymal liver cell fraction enriched in cells with biliary epithelial phenotypes

1989 • 53 citations

Electron microscopical demonstration of glucose-6-phosphatase in native cryostat sections fixed with glutaraldehyde through semipermeable membranes

1979 • 47 citations

Hypomethylation of DNA in ethionine-fed rats

1984 • 45 citations

Correlation of histology and alpha1-fetoprotein resurgence in rat liver regeneration after experimental injury by galactosamine

1980 • 44 citations

Anaplastic carcinomas in nude mice and in original donor strain rats inoculated with cultured oval cells.

1983 • 42 citations

Immunohistochemical demonstration of isozyme- and strain-specific differences in the intralobular localizations and distributions of UDP-glucuronosyltransferases in livers of untreated rats.

1988 • 37 citations

Presence of alpha-fetoprotein-positive cells in hepatocellular foci and microcarcinomas induced by single injections of diethylnitrosamine in infant mice.

1983 • 37 citations

Chemical Carcinogenesis: The Liver as a Model

1986 • 30 citations

Pathogenesis of Primary Liver Tumors Induced by Chemicals

1986 • 27 citations

Three-dimensional arrangement of ductular structures formed by oval cells during hepatocarcinogenesis.

1988 • 26 citations

Persistent reduction of indigenous DNA modification (I-compound) levels in liver DNA from male Fischer rats fed choline-devoid diet and in DNA of resulting neoplasms.

1990 • 26 citations

Comparison of GST-P Versus GGT as Markers of Hepatocellular Lineage During Analyses of Initiation of Carcinogenesis

1988 • 21 citations

gamma-Glutamyl transpeptidase and alpha-fetoprotein expression during alpha-naphthylisothiocyanate-induced hepatotoxicity in rats.

1982 • 20 citations

Bile ductular cells and the phenotypic heterogeneity of the population of hepatic non-parenchymal epithelial cells induced in rats by chemical carcinogens

1986 • 18 citations

Expression of c-Ki-ras, c-Ha-ras, and c-myc in Specific Cell Types During Hepatocarcinogenesis

1985 • 18 citations

Cellular Expression of α-Fetoprotein Gene and Its Relation to Albumin Gene Expression during Rat Azo-Dye Hepatocarcinogenesis

1989 • 12 citations

Distribution of glucose-6-phosphatase activity in normal, hyperplastic, and preneoplastic rat liver

1992 • 11 citations

DNA repair synthesis in primary culture of bovine bile duct epithelial cells induced by chemical agents in relation to bile duct cancer

1988 • 7 citations

Cellular expression of alpha-fetoprotein gene and its relation to albumin gene expression during rat azo-dye hepatocarcinogenesis.

1989 • 6 citations

17β-hydroxysteroid UDP-glucuronosyl transferase is expressed in bile ductular epithelial cells under physiological conditions

1990 • 6 citations