Cell behavior in the acetylaminofluorene-treated regenerating rat liver. Light and electron microscopic observations.

Liver regeneration: molecular mechanisms of growth control

1990 • 922 citations

Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis.

1977 • 541 citations

A precursor—product relationship exists between oval cells and hepatocytes in rat liver

1987 • 448 citations

Cell lineages and oval cell progenitors in rat liver development.

1991 • 391 citations

Regulation of the cytoskeleton in mesothelial cells: Reversible loss of keratin and increase in vimentin during rapid growth in culture

1983 • 331 citations

Oval cell proliferation and the origin of small hepatocytes in liver injury induced by D-galactosamine.

1991 • 309 citations

Is there a liver stem cell?

1990 • 304 citations

Activation, proliferation, and differentiation of progenitor cells into hepatocytes in the D-galactosamine model of liver regeneration.

1993 • 246 citations

Occurrence of oval-type cells in hepatitis B virus—associated human hepatocarcinogenesis

1992 • 195 citations

Role of cholangioles in restoration of the liver of the mouse after dietary injury

1958 • 185 citations

Regulation of the differentiation of diploid and some aneuploid rat liver epithelial (stemlike) cells by the hepatic microenvironment.

1993 • 185 citations

CELL TYPES IN LONG‐TERM PROPAGABLE CULTURES OF RAT LIVER*

1980 • 180 citations

Regulation of hepatic growth

1986 • 173 citations

Electron microscopic studies of normal and proliferated bile ductules.

1961 • 166 citations

Keratin immunohistochemistry in normal human liver. Cytokeratin pattern of hepatocytes, bile ducts and acinar gradient

1987 • 157 citations

Cytokeratin expression in hepatocellular carcinoma: An immunohistochemical study

1988 • 153 citations

Intrahepatic bile duct development in the rat: a cytokeratin-immunohistochemical study.

1988 • 149 citations

The localization of laminin mRNA and protein in the postimplantation embryo and placenta of the mouse: anin situhybridization and immunocytochemical study

1988 • 141 citations

Ultrastructural characteristics of novel epithelial cell types identified in human pathologic liver specimens with chronic ductular reaction.

1992 • 122 citations

Activation of hepatic stem cell compartment in the rat: role of transforming growth factor alpha, hepatocyte growth factor, and acidic fibroblast growth factor in early proliferation.

1993 • 119 citations

Apoptosis: a gene-directed programme of cell death.

1992 • 115 citations

Expression of transforming growth factor‐alpha in regenerating liver and during hepatic differentiation

1992 • 114 citations

Hepatocyte growth factor induces proliferation and morphogenesis in nonparenchymal epithelial liver cells

1993 • 113 citations

Light- and electron-microscopic autoradiographic analysis of proliferating cells during the early stages of chemical hepatocarcinogenesis in the rat induced by feeding N-2-fluorenylacetamide in a choline-deficient diet.

1984 • 105 citations

Intestinal metaplasia as a common option of oval cells in relation to cholangiofibrosis in liver of rats exposed to 2-acetylaminofluorene.

1985 • 101 citations

Phenotypic characterization of hepatic proliferation. Antigenic expression by proliferating epithelial cells in fetal liver, massive hepatic necrosis, and nodular transformation of the liver.

1983 • 98 citations

Histogenesis of bile duct-like cells proliferating during ethionine hepatocarcinogenesis. Evidence for a biliary epithelial nature of oval cells.

1992 • 93 citations

Epidermal growth factor-induced selective phosphorylation of cultured rat hepatocyte 55-kD cytokeratin before filament reorganization and DNA synthesis.

1989 • 85 citations

The stem cells of the liver ? a selective review

1992 • 85 citations

The Nature and Origin of Proliferated Bile Ductules in Alcoholic Liver Disease

1983 • 84 citations

Hepatic stem cells.

1993 • 82 citations

Bile ductules in cholestasis: morphologic evidence for secretion and absorption in man.

1967 • 81 citations

Immunolocalization of regenerating cells after submassive liver necrosis using PCNA staining

1992 • 73 citations

Evidence for a common cell of origin for primitive epithelial cells isolated from rat liver and pancreas

1991 • 68 citations

Characterization of ductular hepatocytes in end-stage cirrhosis.

1990 • 65 citations

Reactive human bile ductules express parathyroid hormone‐related peptide

1993 • 61 citations

Connection of ductlike structures induced by a chemical hepatocarcinogen to portal bile ducts in the rat liver detected by injection of bile ducts with a pigmented barium gelatin medium.

1985 • 61 citations

Distribution of albumin and alpha-fetoprotein mRNAs in normal, hyperplastic, and preneoplastic rat liver.

1992 • 59 citations

A cytokeratin-immunohistochemical study of hepatoblastoma

1990 • 59 citations

α‐FETOPROTEIN AND EARLY HISTOLOGICAL CHANGES OF HEPATIC TISSUE IN DAB‐HEPATOCARCINOGENESIS*

1975 • 55 citations

PROLIFERATION OF BILE DUCTS IN CIRRHOSIS.

1964 • 54 citations

Expression of hepatocyte growth factor mRNA during oval cell activation in the rat liver

1993 • 52 citations

Bile duct proliferation—its true significance?

1993 • 51 citations

Dexamethasone can modulate the synthesis and organization of cytokeratins in cultured differentiating rat hepatocytes

1985 • 42 citations

Vimentin expression of newly formed rat bile duct epithelial cells in secondary biliary fibrosis

1989 • 41 citations

Epithelial cell lineages in developing, restoring, and transforming liver: evidence for the existence of a 'differentiation window'.

1994 • 34 citations

Transforming growth factor‐α immunoreactivity in a variety of epithelial tissues

1993 • 27 citations

Demonstration of glucose-6-phosphatase and peroxisomal catalase activity by ultrastructural cytochemistry in oval cells from livers of carcinogen-treated rats.

1988 • 24 citations

Distinct effects of cell-cell communication and corticosteroids on the synthesis and distribution of cytokeratins in cultured rat hepatocytes

1991 • 23 citations

The search for liver stem cells picks up

1993 • 22 citations

A fluorescence microscopic study of bile duct proliferation induced in guinea pigs by alpha-naphthyl isothiocyanate.

1969 • 21 citations

Analysis of proliferating biliary epithelial cells in human liver disease using a monoclonal antibody against DNA polymeraseα

1993 • 6 citations