Cellular origin of cancer: dedifferentiation or stem cell maturation arrest?

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

Experimental pathology of the liver

1931 • 3,113 citations

Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt

1990 • 1,793 citations

Normal genetically mosaic mice produced from malignant teratocarcinoma cells.

1975 • 1,175 citations

HBx gene of hepatitis B virus induces liver cancer in transgenic mice

1991 • 1,155 citations

Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens

1980 • 854 citations

Integration of Hepatitis B Virus DNA into the Genome of Liver Cells in Chronic Liver Disease and Hepatocellular Carcinoma

1981 • 715 citations

The Action of Oncogenes in the Cytoplasm and Nucleus

1985 • 708 citations

Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice

1989 • 692 citations

Experimental pathology of the liver. Restoration of the liver of the white rat following partial surgical removal

1931 • 684 citations

Similarities in the sequence of early histological changes induced in the liver of the rat by ethionine, 2-acetylamino-fluorene, and 3'-methyl-4-dimethylaminoazobenzene.

1956 • 670 citations

Viral oncogenes

1985 • 605 citations

Hepatocellular carcinoma and the hepatitis B virus: evidence for a causal association.

1978 • 588 citations

The development of transplantable teratocarcinomas from intratesticular grafts of pre- and postimplantation mouse embryos

1970 • 565 citations

Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis.

1977 • 541 citations

The stages of initiation and promotion in hepatocarcinogenesis

1980 • 515 citations

THE EFFECT OF CELLS TRANSFERRED INTO THE MOUSE BLASTOCYST ON SUBSEQUENT DEVELOPMENT

1974 • 512 citations

Genetic errors, cell proliferation, and carcinogenesis.

1991 • 477 citations

Fate of teratocarcinoma cells injected into early mouse embryos

1975 • 461 citations

A precursor—product relationship exists between oval cells and hepatocytes in rat liver

1987 • 448 citations

Cell lineages and oval cell progenitors in rat liver development.

1991 • 391 citations

Structural and pathological effects of synthesis of hepatitis B virus large envelope polypeptide in transgenic mice.

1987 • 353 citations

State of hepatitis B virus DNA in hepatocytes of patients with hepatitis B surface antigen-positive and -negative liver diseases.

1981 • 351 citations

Oval cell proliferation and the origin of small hepatocytes in liver injury induced by D-galactosamine.

1991 • 309 citations

Differentiation of malignant to benign cells

1971 • 306 citations

Is there a liver stem cell?

1990 • 304 citations

Alpha-Fetoprotein 3

1978 • 297 citations

Evidence for the stem cell origin of hepatocellular carcinoma and cholangiocarcinoma.

1989 • 294 citations

THE KINETICS OF CELLULAR PROLIFERATION IN REGENERATING LIVER

1968 • 288 citations

A Transgenic Mouse Model of the Chronic Hepatitis B Surface Antigen Carrier State

1985 • 281 citations

The streaming liver

1985 • 271 citations

Relationship Between Hepatocellular Carcinoma and Cirrhosis

1984 • 264 citations

Phenotypic diversity in experimental hepatomas: the concept of partially blocked ontogeny. The 10th Walter Hubert Lecture

1978 • 260 citations

Tumor promotion in the liver

1985 • 258 citations

Early histological and functional alterations of ethionine liver carcinogenesis in rats fed a choline-deficient diet.

1978 • 248 citations

Regression and persistence of hyperplastic hepatic nodules induced by N-2-Fluorenylacetamide and their relationship to hepatocarcinogenesis.

1971 • 221 citations

Experimental Study of the Pathogenesis of Carcinoma

1918 • 221 citations

Biliary epithelial and hepatocytic cell lineage relationships in embryonic rat liver as determined by the differential expression of cytokeratins, alpha-fetoprotein, albumin, and cell surface-exposed components.

1988 • 213 citations

Hepatocarcinogenesis due to chronic liver cell injury in hepatitis B virus transgenic mice.

1990 • 199 citations

Hepatitis B virus transactivator X protein is not tumorigenic in transgenic mice

1990 • 196 citations

Effects of varying the exposure to phenobarbital on its enhancement of 2-acetylaminofluorene-induced hepatic tumorigenesis in the rat.

1973 • 193 citations

Congenitales, quergestreiftes Muskelsarkom der Nieren

1875 • 191 citations

Teratocarcinogenic and tissue-forming potentials of the cell types comprising neoplastic embryoid bodies.

1960 • 191 citations

Genetic Alterations During Colorectal-Tumor Development

1989 • 187 citations

A comparison of cell replacement in bone marrow, testis and three regions of surface epithelium

1979 • 180 citations

Mitogenic and carcinogenic effects of a hypolipidemic peroxisome proliferator, [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (Wy-14, 643), in rat and mouse liver.

1979 • 180 citations

Testicular teratomas.I. Demonstration of teratogenesis by metamorphosis of multipotential Cells

1959 • 179 citations

An Evaluation of Cellular Lineages in the Pathogenesis of Experimental Hepatocellular Carcinoma

1982 • 176 citations

Cancer : a problem of developmental biology

1978 • 170 citations

Progressive microscopic alterations in the livers of rats fed the hepatic carcinogens 3'-methyl-4-dimethylaminoazobenzene and 4'-fluoro-4-dimethylaminoazobenzene.

1952 • 168 citations

ANALYSIS OF CELL CYCLE COMPARTMENTS OF HEPATOCYTES AFTER PARTIAL HEPATECTOMY

1976 • 158 citations

THE PATHOGENESIS OF TUMORS OF THE LIVER PRODUCED BY BUTTER YELLOW

1944 • 158 citations

Transmission of a Malignant New Growth by Means of a Cell-Free Filtrate

1983 • 143 citations

Isolation, Culture, and Transplantation of Intrahepatic Biliary Epithelial Cells and Oval Cells

1990 • 141 citations

Expression of c-Ki-ras, c-Ha-ras, and c-myc in specific cell types during hepatocarcinogenesis.

1985 • 140 citations

Differentiation of regenerating pancreatic cells into hepatocyte-like cells.

1981 • 138 citations

Ductular cell reaction in the liver in hepatic injury.

1957 • 134 citations

Synergy between hepatitis B virus expression and chemical hepatocarcinogens in transgenic mice.

1991 • 133 citations

Origin and fate of proliferated hepatic ductal cells in the rat: Electron microscopic and autoradiographic studies

1964 • 128 citations

The urodele limb regeneration blastema

1984 • 128 citations

Hepatocyte differentiation and liver progenitor cells

1990 • 125 citations

Regeneration of Liver and Kidney

1971 • 119 citations

Induction and origin of hepatocytes in rat pancreas.

1984 • 119 citations

The effect of aging and interval between primary and secondary treatment in two-stage carcinogenesis on mouse skin.

1975 • 116 citations

Different lineages of chemically induced hepatocellular carcinoma in rats defined by monoclonal antibodies.

1989 • 111 citations

Pre-cancerous steps in carcinogenesis Their physicological adaptive nature

1984 • 110 citations

Production of monoclonal antibodies to preneoplastic liver cell populations induced by chemical carcinogens in rats and to transplantable Morris hepatomas.

1989 • 107 citations

Light- and electron-microscopic autoradiographic analysis of proliferating cells during the early stages of chemical hepatocarcinogenesis in the rat induced by feeding N-2-fluorenylacetamide in a choline-deficient diet.

1984 • 105 citations

Cell lineages and differentiation programs in epidermal, urothelial and hepatic tissues and their neoplasms.

1990 • 98 citations

Clonal origin of human hepatoma determined by integration of hepatitis B virus DNA.

1986 • 93 citations

Immunofluorescent study on alpha-fetoprotein-producing cells in the early stage of 3'-methyl-4-dimethylaminoazobenzene carcinogenesis.

1975 • 92 citations

Distribution of alpha-fetoprotein- and albumin-containing cells in the livers of Fischer rats fed four cycles of N-2-fluorenylacetamide.

1978 • 89 citations

Hepatitis B virus (HBV) and hepatocellular carcinoma

1987 • 89 citations

Phenotypic characterization of metaplastic intestinal glands and ductular hepatocytes in cholangiofibrotic lesions rapidly induced in the caudate liver lobe of rats treated with furan.

1991 • 87 citations

Autoradiography of “oval cells” appearing rapidly in the livers of rats fed N-2-fluorenylacetamide in a choline devoid diet

1981 • 86 citations

Cellular Events During Hepatocarcinogenesis In Rats And The Question Of Premalignancy

1987 • 85 citations

Sequential cellular changes during chemical carcinogenesis

1984 • 82 citations

Localization of ALPHA₁‐fetoprotein and DNA‐synthesis in liver cell populations during experimental hepatocarcinogenesis in rats

1978 • 82 citations

Monoclonal antibodies recognizing oval cells induced in the liver of rats by N-2-fluorenylacetamide or ethionine in a choline-deficient diet.

1985 • 81 citations

Hyperplasia of bile‐ducts induced by alpha‐naphthyl‐iso‐thiocyanate: Experimental biliary cirrhosis free from biliary obstruction

1958 • 80 citations

Cell lineages in liver carcinogenesis: possible clues from studies of the distribution of alpha-fetoprotein RNA sequences in cell populations isolated from normal, regenerating, and preneoplastic rat livers.

1985 • 77 citations

Differential cytokeratin and alpha-fetoprotein expression in morphologically distinct epithelial cells emerging at the early stage of rat hepatocarcinogenesis.

1985 • 72 citations

Effects of a choline-devoid diet on the emergence of gamma-glutamyltranspeptidase-positive foci in the liver of carcinogen-treated rats.

1979 • 63 citations

The origin and fate of proliferated bile ductular cells

1964 • 62 citations

Cellular analysis of alpha-fetoprotein gene activation during carbon tetrachloride and D-galactosamine-induced acute liver injury in rats.

1988 • 61 citations

Differential expression of alpha-fetoprotein and gamma-glutamyltranspeptidase in chemical and spontaneous hepatocarcinogenesis.

1979 • 61 citations

Connection of ductlike structures induced by a chemical hepatocarcinogen to portal bile ducts in the rat liver detected by injection of bile ducts with a pigmented barium gelatin medium.

1985 • 61 citations

Cellular Proliferation in the Liver

1969 • 61 citations

Cell population dynamics in the liver

1966 • 60 citations

Characterization of pancreatic-type tissue in the liver of rat induced by polychlorinated biphenyls.

1986 • 59 citations

Rapid development of large numbers of alpha-fetoprotein-containing "oval" cells in the liver of rats fed N-2-fluorenylacetamide in a choline-devoid diet.

1981 • 58 citations

Sequential histologic study of rat liver during peroxisome proliferator [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]-acetic acid (Wy-14,643)-induced carcinogenesis.

1984 • 58 citations

The streaming liver III. Littoral cells accompany the streaming hepatocyte

1988 • 57 citations

Liver tumour promotion by chemicals: models and mechanisms.

1986 • 56 citations

Characterizations of and interactions between bile ductule cells and hepatocytes in early stages of rat hepatocarcinogenesis induced by ethionine.

1991 • 54 citations

Effects of varying the onset and duration of exposure to phenobarbital on its enhancement of 2-acetylaminofluorene-induced hepatic tumorigenesis.

1977 • 54 citations

Transgenic mice containing hepatitis B virus sequences are more susceptible to carcinogen-induced hepatocarcinogenesis

1990 • 54 citations

Ultrastructural localisation of alpha-fetoprotin (AFP) in regenerating mouse liver poisoned with CCL4

1984 • 49 citations

Comparison of oval cells induced in rat liver by feeding N-2-fluorenylacetamide in a choline-devoid diet and bile duct cells induced by feeding 4,4'-diaminodiphenylmethane.

1983 • 47 citations

The riddle of cancer

1952 • 43 citations

α‐Fetoprotein‐containing cells in the early stages of liver carcinogenesis induced by 3′‐methyl‐4‐dimethyl‐aminoazobenzene and 2‐acetylaminofluorene

1977 • 42 citations

Molecular mechanisms of control of albumin and alphafetoprotein production: A system to study the early effects of chemical hepatocarcinogens

1980 • 39 citations

Failure of the peroxisome proliferator WY-14,643 to induce unscheduled DNA synthesis in rat hepatocytes following in vivo treatment

1988 • 35 citations

Endogenous Carcinogenesis: The Role of Tumor Promotion

1991 • 34 citations

Cirrhosis of the liver

1991 • 33 citations

Pathogenesis of liver cancer.

1974 • 31 citations

Teratomas, neoplasia and differentiation: a biological overview. I. The natural history of teratomas.

1978 • 28 citations

Heterogeneity of alpha-fetoprotein(AFP) and albumin containing cells in normal and pathological permissive states for AFP production: AFP containing cells induced in adult rats recapitulate the appearance of AFP containing hepatocytes in fetal rats.

1980 • 27 citations

Multipotent developmental capacity of cells in the adult animal.

1985 • 26 citations

Peroxisome Proliferator-lnduced Hepatocarcinogenesis: Histochemical Analysis of Ciprofibrate-lnduced Preneoplastic and Neoplastic Lesions for γ-Glutamyl Transpeptidase Activity<xref ref-type="fn" rid="FN2">2</xref>

1986 • 24 citations

Peroxisome proliferator-induced hepatocarcinogenesis: levels of activating and detoxifying enzymes in hepatocellular carcinomas induced by ciprofibrate

1987 • 21 citations

Azathioprine treatment increases hepatocyte turnover

1991 • 20 citations

gamma-Glutamyl transpeptidase and alpha-fetoprotein expression during alpha-naphthylisothiocyanate-induced hepatotoxicity in rats.

1982 • 20 citations

The fate of embryonal-carcinoma cells in mouse blastocysts

1987 • 19 citations

Expression of c-Ki-ras, c-Ha-ras, and c-myc in Specific Cell Types During Hepatocarcinogenesis

1985 • 18 citations

Fundamentals of Oncology

1982 • 11 citations

Initiation and promotion of liver tumorigenesis.

1981 • 10 citations

Persistence of carcinogen induced initiated hepatocytes in liver carcinogenesis

1977 • 9 citations

Monoclonal antibodies to preneoplastic liver cells identify a common epithelial cell precursor of developing rat liver and bile ducts

1988 • 4 citations

Sequential cellular changes during chemical carcinogenesis

1983 • 3 citations

Spontaneous hepatocarcinogenesis in recombinant inbred mouse strains : correlation with serum levels of alpha-fetoprotein

1991 • 2 citations

Discussions: Expository Papers for the Association

1921 • 1 citations