Identification of potent nontoxic poly(ADP-Ribose) polymerase-1 inhibitors: chemopotentiation and pharmacological studies.

New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening

1990 • 9,412 citations

Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor

2002 • 1,771 citations

In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain

1977 • 1,743 citations

(ADP-ribose)n participates in DNA excision repair

1980 • 1,112 citations

Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells

1997 • 1,034 citations

Poly(ADP-ribose) polymerase: a molecular nick-sensor

1994 • 790 citations

Poly(ADP-Ribose) in the Cellular Response to DNA Damage

1985 • 771 citations

Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease.

1995 • 767 citations

Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks

1995 • 600 citations

Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?

2000 • 527 citations

Novel inhibitors of poly(ADP-ribose) synthetase

1980 • 519 citations

Poly (ADP-ribose) polymerase, nitric oxide and cell death

1999 • 518 citations

DNA repair defect in poly(ADP-ribose) polymerase-deficient cell lines

1998 • 350 citations

Involvement of poly(ADP-ribose) polymerase in base excision repair

1999 • 322 citations

The world according to PARP

2001 • 315 citations

Molecular and biochemical features of poly (ADP-ribose) metabolism

1993 • 300 citations

Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes

1999 • 286 citations

Resistance-Modifying Agents. 9. Synthesis and Biological Properties of Benzimidazole Inhibitors of the DNA Repair Enzyme Poly(ADP-ribose) Polymerase

2000 • 281 citations

Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells.

1993 • 242 citations

Poly (ADP-Ribose) synthetase. Separation and identification of three proteolytic fragments as the substrate-binding domain, the DNA-binding domain, and the automodification domain.

1984 • 226 citations

Poly(ADP-ribose) catabolism in mammalian cells exposed to DNA-damaging agents

1989 • 218 citations

Poly(ADP-ribose) Binds to Specific Domains of p53 and Alters Its DNA Binding Functions

1998 • 216 citations

Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines.

2000 • 201 citations

A dominant-negative mutant of human poly(ADP-ribose) polymerase affects cell recovery, apoptosis, and sister chromatid exchange following DNA damage.

1995 • 200 citations

Inhibitor and NAD⁺ Binding to Poly(ADP-ribose) Polymerase As Derived from Crystal Structures and Homology Modeling^,

1998 • 196 citations

The mechanism of the elongation and branching reaction of Poly(ADP-ribose) polymerase as derived from crystal structures and mutagenesis

1998 • 160 citations

Role of Glutamic Acid 988 of Human Poly-ADP-ribose Polymerase in Polymer Formation

1995 • 159 citations

Splitting of the Ribose-Ribose Linkage of Poly(Adenosine Diphosphate-Ribose) by a Calf Thymus Extract

1971 • 148 citations

Potential clinical applications of poly(ADP-ribose) polymerase (PARP) inhibitors

2002 • 143 citations

From DNA damage and stress signalling to cell death : poly-ADP-ribosylation reactions

2000 • 135 citations

Potentiation of temozolomide-induced cytotoxicity: a comparative study of the biological effects of poly(ADP-ribose) polymerase inhibitors

1995 • 131 citations

Novel Tricyclic Poly(ADP-ribose) Polymerase-1 Inhibitors with Potent Anticancer Chemopotentiating Activity: Design, Synthesis, and X-ray Cocrystal Structure

2002 • 130 citations

Function of poly(ADP-ribose) polymerase in response to DNA damage: Gene-disruption study in mice

1999 • 126 citations

trans-Dominant Inhibition of Poly(ADP-Ribosyl)ation Sensitizes Cells against γ-Irradiation and N-Methyl-N′-Nitro-N-Nitrosoguanidine but Does Not Limit DNA Replication of a Polyomavirus Replicon

1995 • 113 citations

Dihydroisoquinolinones: the design and synthesis of a new series of potent inhibitors of poly(ADP-ribose) polymerase.

1991 • 113 citations

Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development

1992 • 107 citations

Inhibition of poly(ADP-ribosyl)ation by overexpressing the poly(ADP-ribose) polymerase DNA-binding domain in mammalian cells.

1990 • 100 citations

The role of inhibitors of poly(ADP-ribose) polymerase as resistance-modifying agents in cancer therapy

1995 • 92 citations

[19] Tissue NAD as a biochemical measure of niacin status in humans

1997 • 92 citations

Defective induction but normal activation and function of p53 in mouse cells lacking poly-ADP-ribose polymerase

1997 • 89 citations

[52] Poly(ADP-ribose) synthetase

1984 • 68 citations

Identification of Autonomously Replicating Sequence (ARS) Elements in Eukaryotic Cells

1997 • 64 citations

Overexpression of dominant negative PARP interferes with tumor formation of HeLa cells in nude mice: Evidence for increased tumor cell apoptosis in vivo

1999 • 27 citations

Structural requirements for inhibitors of poly(ADP-ribose) Polymerase

1990 • 22 citations

Analysis of Biological Molecules: An introduction to principles, instrumentation and techniques

1994 • 5 citations