Role of Glutamic Acid 988 of Human Poly-ADP-ribose Polymerase in Polymer Formation

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

1994 • 823 citations

ADP-RIBOSYLATION

1985 • 710 citations

The crystal structure of diphtheria toxin

1992 • 663 citations

Vectors that facilitate the expression and purification of foreign peptides in Escherichia coli by fusion to maltose-binding protein

1988 • 662 citations

Crystal structure of a cholera toxin-related heat-labile enterotoxin from E. coli

1991 • 556 citations

Diphtheria toxin: mode of action and structure

1975 • 552 citations

An Escherichia coli vector to express and purify foreign proteins by fusion to and separation from maltose-binding protein

1988 • 539 citations

Structure of exotoxin A of Pseudomonas aeruginosa at 3.0-Angstrom resolution.

1986 • 517 citations

Poly(ADP-ribose) synthesis in vitro programmed by damaged DNA. A comparison of DNA molecules containing different types of strand breaks.

1980 • 488 citations

ADP-ribosylation in mammalian cell ghosts. Dependence of poly(ADP-ribose) synthesis on strand breakage in DNA.

1980 • 378 citations

The crystal structure of pertussis toxin

1994 • 343 citations

cAMP‐dependent protein kinase: Crystallographic insights into substrate recognition and phosphotransfer

1994 • 279 citations

The zinc fingers of human poly(ADP-ribose) polymerase are differentially required for the recognition of DNA breaks and nicks and the consequent enzyme activation. Other structures recognize intact DNA.

1990 • 231 citations

Mutation in the Structural Gene for Diphtheria Toxin carried by Temperate Phage β

1971 • 227 citations

Poly (ADP-Ribose) synthetase. Separation and identification of three proteolytic fragments as the substrate-binding domain, the DNA-binding domain, and the automodification domain.

1984 • 226 citations

Subunit assembly and active site location in the structure of glutamate dehydrogenase

1992 • 223 citations

Active site of Pseudomonas aeruginosa exotoxin A. Glutamic acid 553 is photolabeled by NAD and shows functional homology with glutamic acid 148 of diphtheria toxin.

1987 • 213 citations

Zinc-binding domain of poly(ADP-ribose)polymerase participates in the recognition of single strand breaks on DNA

1989 • 192 citations

Insights into autoregulation from the crystal structure of twitchin kinase

1994 • 192 citations

Multiple autopoly(ADP-ribosyl)ation of rat liver poly(ADP-ribose) synthetase. Mode of modification and properties of automodified synthetase.

1981 • 173 citations

NAD binding site of diphtheria toxin: identification of a residue within the nicotinamide subsite by photochemical modification with NAD.

1984 • 150 citations

Structure of poly(adenosine diphosphate ribose): identification of 2'-[1''-ribosyl-2''-(or 3''-)(1'''-ribosyl)]adenosine-5',5'',5'''-tris(phosphate) as a branch linkage.

1979 • 149 citations

Nucleotide sequence of a full-length cDNA for human fibroblast poly(ADP-ribose) polymerase

1987 • 149 citations

Poly(ADP-ribose)polymerase: a perplexing participant in cellular responses to DNA breakage

1991 • 131 citations

Genes coding for the reversible ADP-ribosylation system of dinitrogenase reductase from Rhodospirillum rubrum

1989 • 116 citations

Diphtheria toxin. Site and configuration of ADP-ribosylation of diphthamide in elongation factor 2.

1981 • 115 citations

Exotoxin A of Pseudomonas aeruginosa: substitution of glutamic acid 553 with aspartic acid drastically reduces toxicity and enzymatic activity

1987 • 115 citations

Subunit S1 of pertussis toxin: mapping of the regions essential for ADP-ribosyltransferase activity.

1988 • 105 citations

Poly(ADP-ribose) polymerase auto-modification and interaction with DNA: electron microscopic visualization.

1983 • 101 citations

Poly(ADP‐ribose) polymerase: Molecular biological aspects

1991 • 95 citations

The branching and linear portions of poly(adenosine diphosphate ribose) have the same alpha(1 leads to 2) ribose-ribose linkage.

1981 • 94 citations

Active-site mutations of diphtheria toxin: effects of replacing glutamic acid-148 with aspartic acid, glutamine, or serine

1990 • 91 citations

Diphtheria Toxin and Pseudomonas aeruginosa Exotoxin A: Active-Site Structure and Enzymic Mechanism

1992 • 87 citations

Photoaffinity labeling of diphtheria toxin fragment A with NAD: structure of the photoproduct at position 148.

1985 • 86 citations

Expression and site-directed mutagenesis of the catalytic domain of human poly(ADP-ribose)polymerase in Escherichia coli. Lysine 893 is critical for activity.

1990 • 85 citations

ADP-Ribosylation Reactions

1992 • 81 citations

Macromolecular association of ADP-ribosyltransferase and its correlation with enzymic activity

1990 • 79 citations

Computer modelling of the NAD binding site of ADP‐ribosylating toxins: active‐site structure and mechanism of NAD binding

1991 • 72 citations

Sequence and organization of the mouse poly (ADP-ribose) polymerase gene

1989 • 72 citations

Cloning of cDNA encoding Drosophila poly(ADP-ribose) polymerase: leucine zipper in the auto-modification domain.

1993 • 71 citations

Amino acid sequence homology between the enzymic domains of diphtheria toxin and Pseudomonas aeruginosa exotoxin A

1988 • 65 citations

The carboxyl-terminal domain of human poly(ADP-ribose) polymerase. Overproduction in Escherichia coli, large scale purification, and characterization

1993 • 64 citations

Poly(ADP-ribosy)ation of nuclear proteins. Enzymatic elongation of chemically synthesized ADP-ribose-histone adducts.

1979 • 64 citations

Photolabeling of Glu-129 of the S-1 subunit of pertussis toxin with NAD

1989 • 59 citations

Adenosine Diphosphate Ribosylation of Chicken‐Erythrocyte Histones H1, H5 and High‐Mobility‐Group Proteins by Purified Calf‐Thymus Poly(adenosinediphosphate‐ribose) Polymerase

1982 • 58 citations

Purification and characterization of poly (ADP-ribose) synthetase from human placenta.

1987 • 58 citations

Labeling methods for the study of poly- and mono(ADP-ribose) metabolism in cultured cells

1988 • 57 citations

Toxoid of Pseudomonas aeruginosa exotoxin A generated by deletion of an active-site residue

1988 • 55 citations

Active-Site Mutations of the Diphtheria Toxin Catalytic Domain: Role of Histidine-21 in Nicotinamide Adenine Dinucleotide Binding and ADP-Ribosylation of Elongation Factor 2

1994 • 53 citations

Pseudomonas aeruginosa Exoenzyme S

1992 • 52 citations

Structure of a ricin mutant showing rescue of activity by a noncatalytic residue

1992 • 51 citations

A¹³C NMR study of poly(adenosine diphosphate ribose) and its monomers: evidence of α-(1″→2′) ribofuranosyl ribofuranoside residue

1977 • 50 citations

ADP-ribosylation by cholera toxin: functional analysis of a cellular system that stimulates the enzymic activity of cholera toxin fragment A1

1987 • 49 citations

Identification of an active‐site residue in subunit S1 of pertussis toxin by photocrosslinking to NAD

1989 • 41 citations

Restoration of enzymic activity and cytotoxicity of mutant, E553C, Pseudomonas aeruginosa exotoxin A by reaction with iodoacetic acid.

1988 • 40 citations

Cloning of a full-length cDNA encoding bovine thymus poly(ADP-ribose) synthetase: evolutionarily conserved segments and their potential functions

1990 • 40 citations

Activation of cholera toxin and Escherichia coli heat‐labile enterotoxins by ADP‐ribosylation factors, a family of 20 kDa guanine nucleotide‐binding proteins

1991 • 39 citations

NAD-binding site of the C3-like ADP-ribosyltransferase from Clostridium limosum.

1993 • 38 citations

Pseudomonas aeruginosa exotoxin A: Alterations of biological and biochemical properties resulting from mutation of glutamic acid 553 to aspartic acid

1990 • 37 citations

Use of two-dimensional thin-layer chromatography for the components study of poly(adenosine diphosphate ribose)

1990 • 37 citations

Chicken poly(ADP-ribose) synthetase: complete deduced amino acid sequence and comparison with mammalian enzyme sequences

1991 • 33 citations

Active-site mutations of diphtheria toxin. Tryptophan 50 is a major determinant of NAD affinity.

1994 • 32 citations

Bacterial protein toxins

1995 • 32 citations

Direction of elongation of poly(ADP-ribose) chains. Addition of residues at the polymerase-proximal terminus.

1987 • 31 citations

Presence of poly (ADP‐ribose) polymerase and poly (ADP‐ribose) glycohydrolase in the dinoflagellate Crypthecodinium cohnii

1984 • 30 citations

Molecular interactions between DNA, poly(ADP-ribose) polymerase, and histones.

1988 • 27 citations

Photolabelling of mutant forms of the S1 subunit of pertussis toxin with NAD+

1990 • 22 citations

Expression of human poly(ADP-ribose) polymerase with DNA-dependent enzymatic activity inEscherichia coli

1989 • 20 citations

Structural analysis of the putative regulatory region of the rat gene encoding poly(ADP‐ribose) polymerase

1992 • 19 citations

Cloning and functional expression of poly(ADP‐ribose) polymerase cDNA from Sarcophaga peregrina

1994 • 18 citations