Involvement of poly(ADP-ribose) polymerase in base excision repair

Heterogeneity in Radiation-Induced DNA Damage and Repair in Tumor and Normal Cells Measured Using the "Comet" Assay

1990 • 1,052 citations

Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells

1997 • 1,034 citations

Heterogeneity in Radiation-Induced DNA Damage and Repair in Tumor and Normal Cells Measured Using the “Comet” Assay

2012 • 1,032 citations

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia

1997 • 1,020 citations

XRCC1 Is Specifically Associated with Poly(ADP-Ribose) Polymerase and Negatively Regulates Its Activity following DNA Damage

1998 • 900 citations

Poly(ADP-ribose) polymerase: a molecular nick-sensor

1994 • 790 citations

Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1)

1997 • 779 citations

Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein.

1996 • 775 citations

Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease.

1995 • 767 citations

A superfamily of conserved domains in DNA damage‐ responsive cell cycle checkpoint proteins

1997 • 750 citations

Importance of Poly(ADP-ribose) Polymerase and Its Cleavage in Apoptosis

1998 • 725 citations

Ischemic Brain Injury is Mediated by the Activation of Poly(ADP-Ribose)Polymerase

1997 • 624 citations

PARP is important for genomic stability but dispensable in apoptosis

1997 • 556 citations

Two Pathways for Base Excision Repair in Mammalian Cells

1996 • 520 citations

Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange.

1990 • 403 citations

ADP-ribosylation of proteins. Enzymology and biological significance.

1987 • 374 citations

DNA repair defect in poly(ADP-ribose) polymerase-deficient cell lines

1998 • 350 citations

Involvement of XRCC1 and DNA Ligase III Gene Products in DNA Base Excision Repair

1997 • 328 citations

Molecular and biochemical features of poly (ADP-ribose) metabolism

1993 • 300 citations

ADP-Ribosylation of Proteins

1987 • 288 citations

The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA.

1990 • 271 citations

XRCC1 Protein Interacts with One of Two Distinct Forms of DNA Ligase III

1997 • 261 citations

Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells.

1993 • 242 citations

Structure of the catalytic fragment of poly(AD-ribose) polymerase from chicken.

1996 • 234 citations

Isolation and Characterization of the cDNA Encoding Bovine Poly(ADP-ribose) Glycohydrolase

1997 • 204 citations

A dominant-negative mutant of human poly(ADP-ribose) polymerase affects cell recovery, apoptosis, and sister chromatid exchange following DNA damage.

1995 • 200 citations

Zinc-binding domain of poly(ADP-ribose)polymerase participates in the recognition of single strand breaks on DNA

1989 • 192 citations

NAD(+)-dependent repair of damaged DNA by human cell extracts.

1993 • 191 citations

Depletion of poly(ADP-ribose) polymerase by antisense RNA expression results in a delay in DNA strand break rejoining.

1992 • 171 citations

Dual Function for Poly(ADP-ribose) Synthesis in Response to DNA Strand Breakage

1994 • 168 citations

Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication

1998 • 152 citations

The Expression of Poly(ADP-ribose) Polymerase during Differentiation-Linked DNA Replication Reveals That It Is a Component of the Multiprotein DNA Replication Complex

1996 • 136 citations

Function of poly(ADP-ribose) polymerase in response to DNA damage: Gene-disruption study in mice

1999 • 126 citations

trans-Dominant Inhibition of Poly(ADP-Ribosyl)ation Sensitizes Cells against γ-Irradiation and N-Methyl-N′-Nitro-N-Nitrosoguanidine but Does Not Limit DNA Replication of a Polyomavirus Replicon

1995 • 113 citations

Depletion of nuclear poly(ADP-ribose) polymerase by antisense RNA expression: influences on genomic stability, chromatin organization, and carcinogen cytotoxicity.

1994 • 96 citations

Identification of potential active-site residues in the human poly(ADP-ribose) polymerase.

1993 • 79 citations

The role of poly(ADP-ribosyl)ation

1997 • 68 citations

Requirement for the Expression of Poly(ADP-ribose) Polymerase during the Early Stages of Differentiation of 3T3-L1 Preadipocytes, as Studied by Antisense RNA Induction

1995 • 60 citations

Mutant cells defective in poly(ADP-ribose) synthesis due to stable alterations in enzyme activity or substrate availability

1989 • 54 citations

Trans-dominant inhibition of poly(ADP-ribosyl)ation potentiates carcinogen induced gene amplification in SV40-transformed Chinese hamster cells.

1996 • 43 citations

Inhibition of gene-specific repair of alkylation damage in cells deplated of poly(ADP-ribose) polymerase

1994 • 40 citations

Poly(ADP ribose) polymerase-defective mutant cell clone of mouse L1210 cells

1992 • 22 citations

Increased sensitivity to DNA-alkylating agents in CHO mutants with decreased poly(ADP-ribose) polymerase activity

1994 • 21 citations