Gene regulation technologies in zebrafish

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

Effective targeted gene ‘knockdown’ in zebrafish

2000 • 2,464 citations

Transcriptional Activation by Tetracyclines in Mammalian Cells

1995 • 2,458 citations

Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators

1998 • 1,870 citations

GAL4 system in drosophila: A fly geneticist's swiss army knife

2002 • 1,063 citations

Ecdysone-inducible gene expression in mammalian cells and transgenic mice.

1996 • 858 citations

Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice.

1996 • 779 citations

Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter.

1994 • 777 citations

Large-scale mutagenesis in the zebrafish: in search of genes controlling development in a vertebrate

1994 • 762 citations

Inducible Gene Targeting in Mice Using the Cre/loxSystem

1998 • 756 citations

GAL4 activates transcription in Drosophila

1988 • 521 citations

I-SceI meganuclease mediates highly efficient transgenesis in fish

2002 • 514 citations

MECHANISMS UNDERLYING EXPRESSION OF TN10 ENCODED TETRACYCLINE RESISTANCE

1994 • 508 citations

A large-scale insertional mutagenesis screen in zebrafish

1999 • 489 citations

Small molecule developmental screens reveal the logic and timing of vertebrate development

2000 • 483 citations

Identification of a functional transposase of the Tol2 element, an Ac -like element from the Japanese medaka fish, and its transposition in the zebrafish germ lineage

2000 • 470 citations

Systematic gain-of-function genetics in Drosophila

1998 • 467 citations

Efficient Target-Selected Mutagenesis in Zebrafish

2003 • 443 citations

Laser-induced gene expression in specific cells of transgenic zebrafish

2000 • 433 citations

Transactivation from Gal4-VP16 transgenic insertions for tissue-specific cell labeling and ablation in zebrafish

2007 • 409 citations

Target-Selected Inactivation of the Zebrafish rag1 Gene

2002 • 397 citations

Tales of regeneration in zebrafish

2003 • 389 citations

Use of the Gal4-UAS technique for targeted gene expression in the zebrafish

1999 • 387 citations

Photo-mediated gene activation using caged RNA/DNA in zebrafish embryos

2001 • 367 citations

Zebrafish as a cancer model system

2002 • 357 citations

From embryogenesis to metamorphosis: The regulation and function of drosophila nuclear receptor superfamily members

1995 • 347 citations

A novel role for site-specific recombination in maintenance of bacterial replicons

1981 • 329 citations

Zebrafish: A new model on the pharmaceutical catwalk

2003 • 316 citations

Tracing Transgene Expression in Living Zebrafish Embryos

2001 • 305 citations

The Zebrafish as a Model Organism to Study Development of the Immune System

2003 • 263 citations

Pattern of aromatic and hydrophobic amino acids critical for one of two subdomains of the VP16 transcriptional activator.

1993 • 261 citations

Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia

2005 • 255 citations

The Genetics of Hearing and Balance in Zebrafish

2005 • 254 citations

Imaging in Systems Biology

2007 • 252 citations

Structural adaptability in the ligand-binding pocket of the ecdysone hormone receptor

2003 • 241 citations

Cardiac development in zebrafish: coordination of form and function

2002 • 229 citations

Effects of heat on embryos and foetuses

2003 • 223 citations

Light-controlled gene silencing in zebrafish embryos

2007 • 223 citations

Digitizing life at the level of the cell: high-performance laser-scanning microscopy and image analysis for in toto imaging of development

2003 • 205 citations

Yeast Gal4: a transcriptional paradigm revisited

2006 • 188 citations

Heat shock-inducible Cre/Lox approaches to induce diverse types of tumors and hyperplasia in transgenic zebrafish

2007 • 178 citations

Pituitary Corticotroph Ontogeny and Regulation in Transgenic Zebrafish

2003 • 129 citations

Heat‐shock induction of T‐cell lymphoma/leukaemia in conditional Cre/lox‐regulated transgenic zebrafish

2007 • 121 citations

Zebrafish as an immunological model system

2002 • 119 citations

Dual-Tagging Gene Trap of Novel Genes inDrosophila melanogaster

2001 • 112 citations

Structure and function of the glucocorticoid receptor

1993 • 100 citations

Chemical-inducible, ecdysone receptor-based gene expression system for plants.

2003 • 95 citations

Regulated expression of foreign genes in vivo after germline transfer.

1994 • 86 citations

Tight control of gene expression by a helper-dependent adenovirus vector carrying the rtTA2s-M2 tetracycline transactivator and repressor system

2002 • 71 citations

Conditional expression of a myocardium‐specific transgene in zebrafish transgenic lines

2005 • 70 citations

Small-molecule regulation of zebrafish gene expression

2007 • 68 citations

Homologous Recombination in Zebrafish ES Cells

2006 • 65 citations

Electroporation of DNA, RNA, and morpholinos into zebrafish embryos

2006 • 63 citations

Zebrafish Hsp70 is required for embryonic lens formation

2005 • 62 citations

High‐efficiency gene transfer into adult fish: A new tool to study fin regeneration

2002 • 61 citations

Zebrafish as an experimental model: strategies for developmental and molecular neurobiology studies

2003 • 60 citations

Comparison of the expression patterns of newly identified zebrafish retinoic acid and retinoid X receptors

2006 • 58 citations

Gain-of-Function Screen for Genes That Affect Drosophila Muscle Pattern Formation

2005 • 51 citations

Heat-Inducible Expression of a Reporter Gene Detected by Transient Assay in Zebrafish

2000 • 48 citations

Heat shock-inducible Cre/Lox approaches to induce diverse types of tumors and hyperplasia in transgenic zebrafish

2007 • 47 citations

Inducible control of transgene expression with ecdysone receptor: gene switches with high sensitivity, robust expression, and reduced size

2005 • 40 citations

Fishing for novel angiogenic therapies

2003 • 39 citations

Focal gene misexpression in zebrafish embryos induced by local heat shock using a modified soldering iron

2007 • 33 citations

Development of a methoxyfenozide‐responsive gene switch for applications in plants

2006 • 27 citations

DNA delivery into anterior neural tube of zebrafish embryos by electroporation

2003 • 25 citations

Birth defects and anti–heat shock protein 70 antibodies in early pregnancy

2006 • 24 citations

Genetic approaches to disease and regeneration

2004 • 23 citations

Hormone‐inducible expression of secreted factors in zebrafish embryos

1998 • 23 citations

Downregulation of Gene Expression with Negatively Charged Peptide Nucleic Acids (PNAs) in Zebrafish Embryos

2004 • 20 citations

Development of a tightly regulated and highly inducible ecdysone receptor gene switch for plants through the use of retinoid X receptor chimeras

2006 • 17 citations

Hormone-inducible expression of secreted factors in zebrafish embryos

1998 • 15 citations

Functional characterization of ecdysone receptor gene switches in mammalian cells

2006 • 11 citations

Manipulation of zebrafish embryogenesis by phosphorodiamidate morpholino oligomers indicates minimal non-specific teratogenesis.

2005 • 8 citations