Fishing for novel angiogenic therapies

In Vivo Imaging of Embryonic Vascular Development Using Transgenic Zebrafish

2002 • 2,055 citations

Molecular Distinction and Angiogenic Interaction between Embryonic Arteries and Veins Revealed by ephrin-B2 and Its Receptor Eph-B4

1998 • 1,663 citations

Mutations in the activin receptor–like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2

1996 • 1,089 citations

Notch signaling is required for arterial-venous differentiation during embryonic vascular development

2001 • 899 citations

The Vascular Anatomy of the Developing Zebrafish: An Atlas of Embryonic and Early Larval Development

2001 • 839 citations

sonic hedgehog and vascular endothelial growth factor Act Upstream of the Notch Pathway during Arterial Endothelial Differentiation

2002 • 806 citations

Conditional control of gene expression in the mouse

2001 • 774 citations

Angiogenesis Assays: A Critical Overview

2003 • 698 citations

Sensory Nerves Determine the Pattern of Arterial Differentiation and Blood Vessel Branching in the Skin

2002 • 635 citations

Sonic hedgehog regulates branching morphogenesis in the mammalian lung

1998 • 631 citations

Cardiac troponin T is essential in sarcomere assembly and cardiac contractility

2002 • 614 citations

The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors

2001 • 609 citations

Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo

1996 • 606 citations

Steps toward mapping the human vasculature by phage display

2002 • 591 citations

Nano and microparticles as controlled drug delivery devices.

2000 • 551 citations

cloche, an early acting zebrafish gene, is required by both the endothelial and hematopoietic lineages

1995 • 545 citations

Myc-Induced T Cell Leukemia in Transgenic Zebrafish

2003 • 543 citations

The cloche and spadetail Genes Differentially Affect Hematopoiesis and Vasculogenesis

1998 • 508 citations

Angiogenic network formation in the developing vertebrate trunk

2003 • 505 citations

Small molecule developmental screens reveal the logic and timing of vertebrate development

2000 • 483 citations

Universal GFP reporter for the study of vascular development

2000 • 445 citations

The art and design of genetic screens: zebrafish

2001 • 435 citations

gridlock , an HLH Gene Required for Assembly of the Aorta in Zebrafish

2000 • 427 citations

Use of the Gal4-UAS technique for targeted gene expression in the zebrafish

1999 • 387 citations

Zebrafish as a Model Organism for the Identification and Characterization of Drugs and Genes Affecting p53 Signaling

2002 • 370 citations

Cardiovascular development in the zebrafish I. Myocardial fate map and heart tube formation

1993 • 365 citations

Sonic hedgehogRegulates Proliferation and Inhibits Differentiation of CNS Precursor Cells

1999 • 360 citations

Zebrafish as a cancer model system

2002 • 357 citations

Orchestration of angiogenesis and arteriovenous contribution by angiopoietins and vascular endothelial growth factor (VEGF)

2002 • 335 citations

gridlock, a localized heritable vascular patterning defect in the zebrafish

1995 • 323 citations

Structure and function of the developing zebrafish heart

2000 • 310 citations

Patterning of angiogenesis in the zebrafish embryo

2002 • 302 citations

The zebrafish gene cloche acts upstream of a flk-1 homologue to regulate endothelial cell differentiation

1997 • 290 citations

Evaluation of the effects of intramyocardial injection of DNA expressing vascular endothelial growth factor (VEGF) in a myocardial infarction model in the rat—angiogenesis and angioma formation

2000 • 275 citations

15,000 Unique Zebrafish EST Clusters and Their Future Use in Microarray for Profiling Gene Expression Patterns During Embryogenesis

2003 • 266 citations

Arteries and veins: making a difference with zebrafish

2002 • 263 citations

Induction and differentiation of the zebrafish heart requires fibroblast growth factor 8 (fgf8/acerebellar)

2000 • 262 citations

F<scp>ROM</scp> Z<scp>EBRAFISH TO</scp> H<scp>UMAN</scp>: Modular Medical Models

2002 • 259 citations

Cardiovascular ephrinB2 function is essential for embryonic angiogenesis

2002 • 259 citations

Temperature-sensitive mutations that cause stage-specific defects in Zebrafish fin regeneration.

1995 • 244 citations

phospholipase C gamma-1is required downstream ofvascular endothelial growth factorduring arterial development

2003 • 234 citations

Analysis of a Zebrafish VEGF Receptor Mutant Reveals Specific Disruption of Angiogenesis

2002 • 226 citations

Cardiac morphology and blood pressure in the adult zebrafish

2001 • 221 citations

Zebrafish--the Canonical Vertebrate

2001 • 214 citations

Identification and characterization of zebrafish thrombocytes

1999 • 209 citations

Drug release behavior of beads and microgranules of chitosan

2000 • 204 citations

Dissection of angiogenic signaling in zebrafish using a chemical genetic approach

2002 • 189 citations

Recent Progress in the Development of Anticancer Agents

2002 • 186 citations

Neoplasia in Zebrafish (Danio rerio) Treated with 7,12-Diniethylbenz[a]anthracene by Two Exposure Routes at Different Developmental Stages

2000 • 168 citations

Endothelial Cell Heterogeneity and Organ Specificity

2002 • 158 citations

A zebrafish model for hepatoerythropoietic porphyria

1998 • 146 citations

Convergence of distinct pathways to heart patterning revealed by the small molecule concentramide and the mutation heart-and-soul

2001 • 145 citations

Structure of the tail fin in teleosts

1983 • 134 citations

Molecular addresses in blood vessels as targets for therapy

2001 • 130 citations

Angiogenesis: the role of the microenvironment in flipping the switch

2001 • 130 citations

Xiphophorus Interspecies Hybrids as Genetic Models of Induced Neoplasia

2001 • 127 citations

Rapid Mapping of Zebrafish Mutations With SNPs and Oligonucleotide Microarrays

2002 • 127 citations

Nitric oxide and vascular reactivity in developing zebrafish,Danio rerio

2000 • 124 citations

Construction of a zebrafish cDNA microarray: gene expression profiling of the zebrafish during development

2002 • 117 citations

Ethylnitrosourea Induces Neoplasia in Zebrafish (Danio rerio)

2000 • 106 citations

Angiogenesis in Health and Disease: Insights into Basic Mechanisms and Therapeutic Opportunities

2002 • 103 citations

Clinical manifestations in a large hereditary hemorrhagic telangiectasia (HHT) type 2 kindred

2000 • 100 citations

Digital Motion Analysis As A Tool For Analysing The Shape And Performance of The Circulatory System in Transparent Animals

2000 • 99 citations

Zebrafish dracula encodes ferrochelatase and its mutation provides a model for erythropoietic protoporphyria

2000 • 99 citations

Realizing the potential of zebrafish as a model for human disease

2000 • 95 citations

Non-invasive imaging of blood cell concentration and blood distribution in zebrafishDanio rerioincubated in hypoxic conditionsin vivo

2003 • 93 citations

Sequence and embryonic expression of deltaC in the zebrafish

2000 • 86 citations

Localized arteriole formation directly adjacent to the site of VEGF-Induced angiogenesis in muscle

2003 • 75 citations

Demonstration of the extrinsic coagulation pathway in teleostei: Identification of zebrafish coagulation factor VII

2001 • 71 citations

Genetic Analysis of Hemostasis and Thrombosis Using Vascular Occlusion

2002 • 69 citations

Arteries, Veins, Notch, and VEGF

2002 • 68 citations

Chapter 16 Growth Control in the Ontogenetic and Regenerating Zebrafish Fin

1998 • 65 citations

Building the vertebrate vasculature: research is going swimmingly

2000 • 62 citations

Selective Labeling of Zebrafish Thrombocytes: Quantitation of Thrombocyte Function and Detection during Development

2002 • 58 citations

Influence of swim training on cardiac activity, tissue capillarization, and mitochondrial density in muscle tissue of zebrafish larvae

2003 • 54 citations

Plumbing the mysteries of vascular development using the zebrafish

2002 • 52 citations

Understanding cardiovascular physiology in zebrafish and Xenopus larvae: the use of microtechniques

2003 • 48 citations

Haemostatic screening and identification of zebrafish mutants with coagulation pathway defects: an approach to identifying novel haemostatic genes in man

2000 • 47 citations

The use of microangiography in detecting aberrant vasculature in zebrafish embryos exposed to cadmium

2001 • 45 citations

Prospects for Microtechnology and Nanotechnology in Bioengineering of Replacement Microvessels

2002 • 44 citations

Evolutionary analysis of vertebrate Notch genes

2001 • 35 citations

A Three-Year Retrospective Study of Abdominal Tumors in Zebrafish Maintained in an Aquatic Laboratory Animal Facility

2002 • 34 citations

Clinicopathologic and Molecular Features of Pancreatic Adenocarcinoma Associated with Peutz-Jeghers Syndrome

2003 • 31 citations

Targeting Tumor Vasculature: Reality or a Dream?

2002 • 30 citations

Microinjection of DNA, RNA, and Protein into the Fertilized Zebrafish Egg for Analysis of Gene Function

2003 • 29 citations

Characterization of angiogenesis and inflammation surrounding ePTFE implanted on the epicardium

2002 • 24 citations

Cell and Tissue Transplantation in Zebrafish Embryos

2003 • 16 citations

Transgenic Zebrafish

2003 • 2 citations