Pattern of aromatic and hydrophobic amino acids critical for one of two subdomains of the VP16 transcriptional activator.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

Construction of improved M13 vectors using oligodeoxynucleotide-directed mutagenesis

1983 • 2,609 citations

How eukaryotic transcriptional activators work

1988 • 1,924 citations

GAL4-VP16 is an unusually potent transcriptional activator

1988 • 1,379 citations

Five intermediate complexes in transcription initiation by RNA polymerase II

1989 • 1,033 citations

Mechanism of transcriptional activation by Sp1: Evidence for coactivators

1990 • 1,029 citations

Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of Yeast

1986 • 946 citations

High level transient expression of a chloramphenicol acetyl transferase gene by DEAE-dextran mediated DNA transfection coupled with a dimethyl sulfoxide or glycerol shock treatment

1984 • 898 citations

Deletion analysis of GAL4 defines two transcriptional activating segments

1987 • 898 citations

Chromatin as an essential part of the transcriptional mechanim

1992 • 853 citations

Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression.

1988 • 830 citations

Oligonucleotide-directed mutagenesis using M13-derived vectors: an efficient and general procedure for the production of point mutations in any fragment of DNA

1982 • 764 citations

A eukaryotic transcriptional activator bearing the DNA specificity of a prokaryotic repressor

1985 • 686 citations

Direct and selective binding of an acidic transcriptional activation domain to the TATA-box factor TFIID

1990 • 620 citations

Activators and targets

1990 • 582 citations

Identification of herpes simplex virus DNA sequences which encode a trans-acting polypeptide responsible for stimulation of immediate early transcription

1984 • 567 citations

Mechanism of action of an acidic transcriptional activator in vitro

1991 • 557 citations

Critical Structural Elements of the VP16 Transcriptional Activation Domain

1991 • 461 citations

A novel mediator between activator proteins and the RNA polymerase II transcription apparatus

1990 • 450 citations

Regulation of α genes of herpes simplex virus: Expression of chimeric genes produced by fusion of thymidine kinase with α gene promoters

1981 • 449 citations

Genetic isolation of ADA2: A potential transcriptional adaptor required for function of certain acidic activation domains

1992 • 446 citations

Acid blobs and negative noodles

1988 • 438 citations

A herpesvirus trans-activating protein interacts with transcription factor OTF-1 and other cellular proteins.

1988 • 381 citations

Role of Nucleosomal Cores and Histone H1 in Regulation of Transcription by RNA Polymerase II

1991 • 379 citations

Sequence-Specific Antirepression of Histone H1-Mediated Inhibition of Basal RNA Polymerase II Transcription

1991 • 378 citations

Herpes simplex virus regulatory elements and the immunoglobulin octamer domain bind a common factor and are both targets for virion transactivation

1988 • 377 citations

Reduced binding of TFIID to transcriptionally compromised mutants of VP16

1991 • 362 citations

A complex formed between cell components and an HSV structural polypeptide binds to a viral immediate early gene regulatory DNA sequence

1988 • 360 citations

Commitment and activation at pol II promoters: A tail of protein-protein interactions

1990 • 332 citations

Transcription in yeast activated by a putative amphipathic α helix linked to a DNA binding unit

1987 • 324 citations

Selective inhibition of activated but not basal transcription by the acidic activation domain of VP16: Evidence for transcriptional adaptors

1990 • 312 citations

Evidence of DNA: protein interactions that mediate HSV-1 immediate early gene activation by VP16.

1988 • 289 citations

Mutants of GAL4 protein altered in an activation function

1987 • 281 citations

Activation domains of stably bound GAL4 derivatives alleviate repression of promoters by nucleosomes

1991 • 242 citations

Transcription elongation and eukaryotic gene regulation.

1990 • 227 citations

Polymerase II Promoter Activation: Closed Complex Formation and ATP-Driven Start Site Opening

1992 • 220 citations

Binding of the virion protein mediating alpha gene induction in herpes simplex virus 1-infected cells to its cis site requires cellular proteins.

1987 • 217 citations

Role of nucleosomal cores and histone H1 in regulation of transcription by RNA polymerase II

1991 • 204 citations

Postinitiation Transcriptional Control in Drosophila melanogaster

1990 • 177 citations

Irresistible force meets immovable object: Transcription and the nucleosome

1991 • 175 citations

Direct combinatorial interaction between a herpes simplex virus regulatory protein and a cellular octamer-binding factor mediates specific induction of virus immediate-early gene expression.

1988 • 157 citations

The C-terminal 79 amino acids of the herpes simplex virus regulatory protein, Vmw65, efficiently activate transcription in yeast and mammalian cells in chimeric DNA-binding proteins.

1989 • 127 citations

RNA polymerase: regulation of transcript elongation and termination

1991 • 127 citations

The Epstein-Barr virus R transactivator (Rta) contains a complex, potent activation domain with properties different from those of VP16

1992 • 113 citations

Separation of requirements for protein-DNA complex assembly from those for functional activity in the herpes simplex virus regulatory protein Vmw65

1989 • 96 citations

Purification and characterization of the carboxyl-terminal transactivation domain of Vmw65 from herpes simplex virus type 1.

1992 • 93 citations

Delineation of transcriptional control signals within the Moloney murine sarcoma virus long terminal repeat.

1985 • 89 citations

Structural studies of the acidic transactivation domain of the Vmw65 protein of herpes simplex virus using proton NMR

1992 • 72 citations

Mutational analysis of the herpes simplex virus trans-inducing factor Vmw65

1989 • 52 citations

Delineation of Transcriptional Control Signals Within the Moloney Murine Sarcoma Virus Long Terminal Repeat

1985 • 38 citations

Acid helix‐turn activator motif

1990 • 12 citations