Systematic gain-of-function genetics in Drosophila

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

Mutations affecting segment number and polarity in Drosophila

1980 • 4,280 citations

A gene complex controlling segmentation in Drosophila

1978 • 3,668 citations

Expression of a single transfected cDNA converts fibroblasts to myoblasts

1987 • 3,373 citations

Genetic Control of the Cell Division Cycle in Yeast

1974 • 1,588 citations

Actin-Based Cell Motility and Cell Locomotion

1996 • 1,536 citations

A stable genomic source of P element transposase in Drosophila melanogaster.

1988 • 1,359 citations

The Biology of heat shock proteins and molecular chaperones.

1994 • 1,226 citations

The biology of heat shock proteins and molecular chaperones

1994 • 1,203 citations

Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos

1992 • 1,176 citations

Dual Roles for Patched in Sequestering and Transducing Hedgehog

1996 • 889 citations

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase

1991 • 869 citations

Compartment boundaries and the control of Drosopfiffa limb pattern by hedgehog protein

1994 • 842 citations

Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoid

1991 • 799 citations

Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer

1996 • 757 citations

Neuronal position in the developing brain is regulated by mouse disabled-1

1997 • 698 citations

The activities of two Ets-related transcription factors required for drosophila eye development are modulated by the Ras/MAPK pathway

1994 • 690 citations

Mena, a Relative of VASP and Drosophila Enabled, Is Implicated in the Control of Microfilament Dynamics

1996 • 667 citations

Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells

1987 • 657 citations

Scrambler and yotari disrupt the disabled gene and produce a reeler -like phenotype in mice

1997 • 637 citations

Modulation of Cellular Thermoresistance and Actin Filament Stability Accompanies Phosphorylation-Induced Changes in the Oligomeric Structure of Heat Shock Protein 27

1995 • 631 citations

Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing

1996 • 629 citations

A modular misexpression screen in Drosophila detecting tissue-specific phenotypes.

1996 • 564 citations

The suppressor of hairless protein participates in notch receptor signaling

1994 • 547 citations

Modulation of actin microfilament dynamics and fluid phase pinocytosis by phosphorylation of heat shock protein 27.

1993 • 544 citations

Expression cloning of Siamois, a xenopus homeobox gene expressed in dorsal-vegetal cells of blastulae and able to induce a complete secondary axis

1995 • 521 citations

The C. elegans genome sequencing project: a beginning

1992 • 496 citations

Gene disruptions using P transposable elements: an integral component of the Drosophila genome project.

1995 • 472 citations

Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings.

1994 • 451 citations

The Role of the Genome Project in Determining Gene Function: Insights from Model Organisms

1996 • 450 citations

breathless, a Drosophila FGF receptor homolog, is essential for migration of tracheal and specific midline glial cells.

1992 • 419 citations

A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways

1994 • 417 citations

The TGFβ homolog dpp and the segment polarity gene hedgehog are required for propagation of a morphogenetic wave in the Drosophila retina

1993 • 414 citations

Multicopy suppression of the cdc24 budding defect in yeast by CDC42 and three newly identified genes including the ras-related gene RSR1.

1989 • 406 citations

Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing

1995 • 392 citations

Complete DNA sequence of yeast chromosome XI

1994 • 377 citations

Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway

1995 • 327 citations

slow border cells, a locus required for a developmentally regulated cell migration during oogenesis, encodes Drosophila CEBP

1992 • 326 citations

Insertional mutagenesis and rapid cloning of essential genes in zebrafish

1996 • 282 citations

Role of Drosophila α-Adaptin in Presynaptic Vesicle Recycling

1997 • 263 citations

enabled, a dosage-sensitive suppressor of mutations in the Drosophila Abl tyrosine kinase, encodes an Abl substrate with SH3 domain-binding properties.

1995 • 256 citations

Pattern-specific expression of the Drosophila decapentaplegic gene in imaginal disks is regulated by 3' cis-regulatory elements.

1990 • 250 citations

Drosophila abl tyrosine kinase in embryonic CNS axons: A role in axonogenesis is revealed through dosage-sensitive interactions with disabled

1989 • 240 citations

wingless inhibits morphogenetic furrow movement in the Drosophila eye disc

1995 • 229 citations

14 Expression and Function of the Low-molecular-weight Heat Shock Proteins

1994 • 223 citations

An HMG-like protein that can switch a transcriptional activator to a repressor

1994 • 220 citations

Genetic dissection of a neurodevelopmental pathway: Son of sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases

1991 • 209 citations

Specificity of bone morphogenetic protein-related factors: cell fate and gene expression changes in Drosophila embryos induced by decapentaplegic but not 60A.

1994 • 195 citations

patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets

1995 • 185 citations

The scalloped gene encodes a novel, evolutionarily conserved transcription factor required for sensory organ differentiation in Drosophila.

1992 • 180 citations

Expression and function of the low-molecular-weight heat shock proteins

1994 • 152 citations

Distinct mitogenic and cell fate specification functions ofwinglessin different regions of the wing

1996 • 151 citations

Quantitative effects of hedgehog and decapentaplegic activity on the patterning of the Drosophila wing

1995 • 145 citations

Efficient and dispersed local P element transposition from Drosophila females.

1993 • 124 citations

Development of an efficient two-element transposon tagging system in Arabidopsis thaliana

1992 • 105 citations

Control of imaginal cell development by the escargot gene of Drosophila

1993 • 100 citations

Dominant genetics using a yeast genomic library under the control of a strong inducible promoter.

1992 • 99 citations

The spatial and temporal expression pattern of sevenless is exclusively controlled by gene-internal elements.

1989 • 99 citations

A Cdc2 dependent checkpoint maintains diploidy in Drosophila

1996 • 97 citations

Control of imaginal cell development by the escargot gene of Drosophila

1993 • 83 citations

Transient activation of a distinct serine protein kinase is responsible for 27-kDa heat shock protein phosphorylation in mitogen-stimulated and heat-shocked cells.

1993 • 82 citations

Receptor tyrosine kinase‐dependent neural crest migration in response to differentially localized growth factors

1997 • 79 citations

EMBRYONIC PATTERN FORMATION IN FLOWERING PLANTS

1994 • 72 citations

Transposon tagging using Ty elements in yeast.

1988 • 67 citations

[41] Insertional mutagenesis by retroviruses and promoter traps in embryonic stem cells

1993 • 58 citations

The Breathless FGF receptor homolog, a downstream target of Drosophila C/EBP in the developmental control of cell migration

1995 • 55 citations

Regulation of the complex pattern of sevenless expression in the developing Drosophila eye.

1989 • 51 citations

Homeotic genes, the homeobox, and the spatial organization of the embryo.

1985 • 42 citations

The transcriptional corepressor DSP1 inhibits activated transcription by disrupting TFIIA-TBP complex formation.

1996 • 35 citations

Specification of C/EBP Function During Drosophila Development by the bZIP Basic Region

1994 • 33 citations

Ras1-dependent signaling by ectopically-expressed Drosophila src gene product in the embryo and developing eye.

1993 • 28 citations