Hoxb-4 (Hox-2.6) mutant mice show homeotic transformation of a cervical vertebra and defects in the closure of the sternal rudiments

A gene complex controlling segmentation in Drosophila

1978 • 3,668 citations

The scanning model for translation: an update.

1989 • 3,525 citations

Homeobox genes and axial patterning

1992 • 2,688 citations

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1991 • 2,028 citations

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

1990 • 1,531 citations

The murine and Drosophila homeobox gene complexes have common features of organization and expression

1989 • 1,021 citations

Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid

1991 • 1,007 citations

The structure and function of the homeodomain

1989 • 1,007 citations

Crystal structure of an engrailed homeodomain-DNA complex at 2.8 Å resolution: A framework for understanding homeodomain-DNA interactions

1990 • 996 citations

The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes.

1989 • 912 citations

Homeo Boxes in the Study of Development

1987 • 905 citations

α-lnhibin is a tumour-suppressor gene with gonadal specificity in mice

1992 • 887 citations

Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5

1991 • 856 citations

Segmental patterns of neuronal development in the chick hindbrain

1989 • 840 citations

Expression of a Bacterial Gene in Mammalian Cells

1980 • 788 citations

Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression

1991 • 698 citations

Molecular Genetics of the Bithorax Complex in Drosophila melanogaster

1983 • 616 citations

Murine Developmental Control Genes

1990 • 594 citations

Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain

1989 • 566 citations

Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox geneHox-#150;1.6

1992 • 537 citations

A single amino acid can determine the DNA binding specificity of homeodomain proteins

1989 • 531 citations

A distinct Hox code for the branchial region of the vertebrate head

1991 • 503 citations

The sequence specificity of homeodomain-DNA interaction

1988 • 501 citations

DNA specificity of the bicoid activator protein is determined by homeodomain recognition helix residue 9

1989 • 487 citations

Protein-DNA contacts in the structure of a homeodomain-DNA complex determined by nuclear magnetic resonance spectroscopy in solution.

1990 • 460 citations

Homeobox proteins as sequence-specific transcription factors

1988 • 397 citations

Variations of cervical vertebrate after expression of a Hox-1.1 transgene in mice

1990 • 371 citations

Homeosis in the mouse induced by a null mutation in the Hox-3.1 gene

1992 • 364 citations

Molecular and Genetic Organization of The Antennapedia Gene Complex of Drosophila melanogaster

1990 • 360 citations

Mechanisms of vertebrate segmentation

1988 • 356 citations

Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells

1991 • 338 citations

Homeotic transformation of the occipital bones of the skull by ectopic expression of a homeobox gene

1992 • 289 citations

Multiple spatially specific enhancers are required to reconstruct the pattern of Hox-2.6 gene expression.

1991 • 286 citations

Craniofacial abnormalities induced by ectopic expression of the homeobox gene Hox-1.1 in transgenic mice

1989 • 262 citations

Patterning the vertebrate head: murine Hox 2 genes mark distinct subpopulations of premigratory and migrating cranial neural crest

1991 • 246 citations

Autoregulation of a drosophila homeotic selector gene

1988 • 229 citations

Human Hox-4.2 and Drosophila Deformed encode similar regulatory specificities in Drosophila embryos and larvae

1990 • 225 citations

Genomic DNA microextraction: A method to screen numerous samples

1992 • 221 citations

HOX gene activation by retinoic acid

1991 • 211 citations

Transgenic mice overexpressing the mouse homoeobox-containing gene Hox-1.4 exhibit abnormal gut development

1989 • 211 citations

Mouse homeo-genes within a subfamily, Hox-1.4, -2.6 and -5.1, display similar anteroposterior domains of expression in the embryo, but show stage- and tissue-dependent differences in their regulation

1989 • 192 citations

Evolution of the vertebrate Hox homeobox genes

1992 • 179 citations

Production of chimaeric mice containing embryonic stem (ES) cells carrying a homoeobox Hox 1.1 allele mutated by homologous recombination

1989 • 166 citations

Homeotic transformations in the mouse induced by overexpression of a human Hox3.3 transgene

1992 • 160 citations

Hox-5.1 defines a homeobox-containing gene locus on mouse chromosome 2.

1988 • 151 citations

Characterization of a murine homeo box gene, Hox-2.6, related to the Drosophila Deformed gene.

1988 • 146 citations

Interference with function of a homeobox gene in Xenopus embryos produces malformations of the anterior spinal cord

1989 • 134 citations

Embryonic expression and nuclear localization of Xenopus homeobox (Xhox) gene products.

1986 • 133 citations

Differential utilization of the same reading frame in a Xenopus homeobox gene encodes two related proteins sharing the same DNA-binding specificity.

1988 • 129 citations

Organization of human homeobox genes

1988 • 127 citations

Hox Codes and Positional Specification in Vertebrate Embryonic Axes

1992 • 126 citations

Altering the boundaries of Hox3.1 expression: Evidence for antipodal gene regulation

1992 • 125 citations

Analysis of the murine Hox-2.7 gene: conserved alternative transcripts with differential distributions in the nervous system and the potential for shared regulatory regions.

1992 • 123 citations

Differential antero-posterior expression of two proteins encoded by a homeobox gene in Xenopus and mouse embryos.

1988 • 121 citations

Microinjection of synthetic Xhox-1A homeobox mRNA disrupts somite formation in developing Xenopus embryos

1988 • 111 citations

Somitomeres: mesodermal segments of vertebrate embryos

1988 • 107 citations

At least three human homeoboxes on chromosome 12 belong to the same transcription unit

1988 • 105 citations

Infertility in Male Transgenic Mice: Disruption of Sperm Development by HSV-tk Expression in Postmeiotic Germ Cells1

1990 • 101 citations

The mouse Hox-1.4 gene: primary structure, evidence for promoter activity and expression during development

1989 • 100 citations

Homeodomain-independent activity of the fushi tarazu polypeptide in Drosophila embryos

1992 • 96 citations

Expression patterns of mouse hox genes: Clues to an understanding of developmental and evolutionary strategies

1991 • 92 citations

Studies on the morphogenesis of the mouse sternum. I. Normal embryonic development.

1952 • 81 citations

Deformed autoregulatory element from Drosophila functions in a conserved manner in transgenic mice

1992 • 71 citations

Position-specific activity of the Hox1.1 promoter in transgenic mice

1990 • 69 citations

Variability of response in experimental animals

1956 • 68 citations

Phylogenetic distribution of Antennapedia-like homoeo boxes

1986 • 68 citations

Position-specific activity of the Hox 1.1 promoter in transgenic mice

1990 • 67 citations

Introduction

1988 • 63 citations

Studies on the morphogenesis of the mouse sternum. III. Experiments on the closure and segmentation of the sternal bands.

1953 • 62 citations

Genetical studies on the skeleton of the mouse. I. Minor variations of the vertebral column.

1950 • 57 citations

How is the mouse segmented?

1985 • 54 citations

Sequence and embryonic expression of the murine Hox-3.5 gene

1992 • 53 citations

Genetical studies on the skeleton of the mouse

1950 • 47 citations

The three most downstream genes of the Hox-3 cluster are expressed in human extraembryonic tissues including trophoblast of androgenetic origin

1990 • 28 citations

Development of the sternum in screw tail mice

1945 • 25 citations

Investigation of Coelectroporation as a Method for Introducing Small Mutations into Embryonic Stem Cells

1992 • 22 citations

Sensitivity patterns for the induction of homeotic shifts in a favorable strain of mice,

1979 • 18 citations

Investigation of coelectroporation as a method for introducing small mutations into embryonic stem cells.

1992 • 16 citations