Enhanced B-1 Cell Development, But Impaired IgG Antibody Responses in Mice Deficient in Secreted IgM

The Instructive Role of Innate Immunity in the Acquired Immune Response

1996 • 1,731 citations

Clonal selection and learning in the antibody system

1996 • 1,710 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

Germinal Centers

1994 • 1,680 citations

C3d of Complement as a Molecular Adjuvant: Bridging Innate and Acquired Immunity

1996 • 1,172 citations

In Vivo Ablation of Surface Immunoglobulin on Mature B Cells by Inducible Gene Targeting Results in Rapid Cell Death

1997 • 1,091 citations

Two mRNAs can be produced from a single immunoglobulin μ gene by alternative RNA processing pathways

1980 • 880 citations

Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene

1993 • 756 citations

Defective B cell development and function in Btk-deficient mice

1995 • 729 citations

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations.

1991 • 683 citations

CD19: Lowering the Threshold for Antigen Receptor Stimulation of B Lymphocytes

1992 • 673 citations

Impairment of T-cell-dependent B-cell responses and B-l cell development in CD19-deficient mice

1995 • 663 citations

Two mRNAs with different 3′ ends encode membrane-bound and secreted forms of immunoglobulin μ chain

1980 • 659 citations

Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines

1984 • 644 citations

Development of the Primary Antibody Repertoire

1987 • 629 citations

Progenitors for Ly-1 B cells are distinct from progenitors for other B cells.

1985 • 599 citations

IL-5-Deficient Mice Have a Developmental Defect in CD5+ B-1 Cells and Lack Eosinophilia but Have Normal Antibody and Cytotoxic T Cell Responses

1996 • 595 citations

Origin of Murine B Cell Lineages

1993 • 579 citations

Natural autoantibodies

1995 • 569 citations

Hyperresponsive B Cells in CD22-Deficient Mice

1996 • 530 citations

Ly‐1 B (B‐1) cells are the main source of B cell‐derived interleukin 10

1992 • 525 citations

Mechanism and Regulation of Immunoglobulin Isotype Switching

1993 • 516 citations

The Classical Complement Pathway: Activation and Regulation of the First Complement Component

1985 • 514 citations

Disruption of the Cr2 Locus Results in a Reduction in B-1a Cells and in an Impaired B Cell Response to T-Dependent Antigen

1996 • 494 citations

Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers.

1995 • 481 citations

Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2.

1996 • 477 citations

Collectins: collagenous C-type lectins of the innate immune defense system

1994 • 461 citations

Structure and Function of the Complement Receptors, CR1 (CD35) and CR2 (CD21)

1989 • 460 citations

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers.

1992 • 456 citations

Germinal centres in T-cell-dependent antibody responses

1992 • 442 citations

Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences.

1990 • 414 citations

Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

1995 • 401 citations

Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generation.

1990 • 396 citations

Regulation of the B cell response to T-dependent antigens by classical pathway complement.

1996 • 369 citations

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells.

1993 • 367 citations

Second generation immune networks

1991 • 339 citations

COMPETITION OF 19S AND 7S ANTIGEN RECEPTORS IN THE REGULATION OF THE PRIMARY IMMUNE RESPONSE

1968 • 328 citations

Life and Death in Germinal Centers (Redux)

1996 • 315 citations

Differential development of progenitor activity for three B-cell lineages.

1992 • 305 citations

Transgenic mice expressing a B cell growth and differentiation factor gene (interleukin 5) develop eosinophilia and autoantibody production.

1991 • 303 citations

Production of Immunoglobulin Isotypes by Ly-1 ⁺ B Cells in Viable Motheaten and Normal Mice

1986 • 290 citations

Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice

1992 • 281 citations

Soluble CD40 ligand can replace the normal T cell-derived CD40 ligand signal to B cells in T cell-dependent activation.

1993 • 261 citations

The CD19/CD21 signal transduction complex of B lymphocytes

1994 • 254 citations

Microanatomy of Lymphoid Tissue During Humoral Immune Responses: Structure Function Relationships

1989 • 253 citations

CD5 B Cells, a Fetal B Cell Lineage

1993 • 252 citations

Immunological Memory

1993 • 250 citations

Antibody response to a T-dependent antigen requires B cell expression of complement receptors.

1996 • 236 citations

Treatment of murine CD5⁻ B cells with anti-lg, but not LPS, induces surface CD5: two B-cell activation pathways

1991 • 224 citations

V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer.

1993 • 219 citations

Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells.

1993 • 218 citations

The Immunoglobulin Class Switch: Beyond “Accessibility”

1997 • 217 citations

Women Fight Uphill Battle for Equity

1996 • 213 citations

Immunoglobulin‐bearing B cells reconstitute and maintain the murine Ly‐1 B cell lineage

1986 • 205 citations

Continuous anti-interleukin 10 antibody administration depletes mice of Ly-1 B cells but not conventional B cells.

1992 • 197 citations

Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus.

1993 • 190 citations

Natural antibody and complement-mediated antigen processing and presentation by B lymphocytes.

1994 • 184 citations

Deletion of the Igκ Light Chain Intronic Enhancer/Matrix Attachment Region Impairs but Does Not Abolish VκJκ Rearrangement

1996 • 172 citations

Oral administration of lipopolysaccharides activates B-1 cells in the peritoneal cavity and lamina propria of the gut and induces autoimmune symptoms in an autoantibody transgenic mouse.

1994 • 167 citations

The Igκ 3′ Enhancer Influences the Ratio of Igκ versus Igλ B Lymphocytes

1996 • 166 citations

Feedback regulation of murine Ly‐1 B cell development

1989 • 161 citations

The CD19 signal transduction molecule is a response regulator of B-lymphocyte differentiation.

1995 • 158 citations

Memory B cells at successive stages of differentiation. Affinity maturation and the role of IgD receptors

1980 • 156 citations

An embryonic source of Ly1 but not conventional B cells

1991 • 145 citations

B-1 cells are made, not born

1993 • 141 citations

The immune complex: possible ways of regulating the antibody response

1990 • 134 citations

Role of Complement in the Induction of Immunological Responses

1976 • 124 citations

Regulation of B lymphocyte development and activation by the CD19/CD21/CD81/Leu 13 complex requires the cytoplasmic domain of CD19.

1997 • 121 citations

Permanent alteration of the murine Ly‐1 B repertoire due to selective depletion of Ly‐1 B cells in neonatal animals

1989 • 116 citations

B-cell lineages exist in the mouse

1993 • 113 citations

Autoimmunity : physiology and disease

1993 • 111 citations

Abnormal transcription factor induction through the surface immunoglobulin M receptor of B-1 lymphocytes.

1993 • 106 citations

Complement and the immune response

1997 • 96 citations

Effects of Breeding Environments on Generation and Activation of Autoreactive B-1 Cells in Anti-red Blood Cell Autoantibody Transgenic Mice

1997 • 90 citations

Specific monoclonal IgM is a potent adjuvant in murine malaria vaccination

1983 • 88 citations

Antigen-dependent IgM-mediated enhancement of the sheep erythrocyte response in mice. Evidence for induction of B cells with specificities other than that of the injected antibodies

1982 • 85 citations

Impaired humoral immune response in complement C3-deficient guinea pigs: absence of secondary antibody response

1986 • 80 citations

Generation of memory cells. III. Antibody class requirements for the generation of B-memory cells by antigen--antibody complexes.

1979 • 72 citations

Interleukin 5 regulation of peritoneal Ly‐1 B lymphocyte proliferation, differentiation and autoantibody secretion

1989 • 69 citations

Antigen-receptor cross-linking induces peritoneal B-cell apoptosis in normal but not autoimmunity-prone mice

1994 • 62 citations

The physiology of germinal centers.

1996 • 53 citations

Regulation of the immune response by antibody

1972 • 53 citations

Characterization of naturally occurring autoantibodies against tumour necrosis factor-alpha (TNF-α):in vitrofunction and precise epitope mapping by phage epitope library

1994 • 43 citations

Influence of interleukin‐6 (IL‐6) autoantibodies on IL‐6 binding to cellular receptors

1995 • 43 citations

Surface Markers, Heavy Chain Sequences and B Cell Lineages

1992 • 40 citations

Specific IgM Enhances and IgG Inhibits the Induction of Immunological Memory in Mice

1985 • 39 citations

Regulation of the Immune Response with Antigen Specific IgM Antibody: A Dual Role

1973 • 38 citations

Autoimmunity: from physiology to pathology. Natural antibodies, mucosal immunity and development of B cell repertoire.

1992 • 36 citations

Regulation of antibody responses by antibody towards the immunogen

1982 • 29 citations

II. IgM-mediated enhancement: dependency on antigen dose, T-cell requirement and lack of evidence for an idiotype-related mechanism.

1983 • 21 citations