Signaling through sphingolipid microdomains of the plasma membrane: the concept of signaling platform.

Regulation of Renal Organic Anion Transporter 3 (SLC22A8) Expression and Function by the Integrity of Lipid Raft Domains and their Associated Cytoskeleton

2013 • 2,950 citations

FUNCTIONS OF LIPID RAFTS IN BIOLOGICAL MEMBRANES

1998 • 2,942 citations

Protein modules and signalling networks

1995 • 2,447 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

Signaling Through Scaffold, Anchoring, and Adaptor Proteins

1997 • 2,268 citations

THE CAVEOLAE MEMBRANE SYSTEM

1998 • 1,947 citations

Caveolins, a Family of Scaffolding Proteins for Organizing “Preassembled Signaling Complexes” at the Plasma Membrane

1998 • 1,502 citations

GPI-anchored proteins are organized in submicron domains at the cell surface

1998 • 1,207 citations

Lipid Domain Structure of the Plasma Membrane Revealed by Patching of Membrane Components

1998 • 1,193 citations

Characterization of a multicomponent receptor for GDNF

1996 • 1,086 citations

T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains

1999 • 964 citations

Structure and Origin of Ordered Lipid Domains in Biological Membranes

1998 • 962 citations

Membrane Compartmentation Is Required for Efficient T Cell Activation

1998 • 925 citations

GPI-Anchored Cell-Surface Molecules Complexed to Protein Tyrosine Kinases

1991 • 848 citations

Characterization of lipid bilayer phases by confocal microscopy and fluorescence correlation spectroscopy

1999 • 841 citations

LAT Palmitoylation

1998 • 837 citations

Caveolae, DIGs, and the dynamics of sphingolipid—cholesterol microdomains

1997 • 783 citations

Protein Lipidation in Cell Signaling

1995 • 771 citations

CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130

1992 • 693 citations

Interactions between saturated acyl chains confer detergent resistance on lipids and glycosylphosphatidylinositol (GPI)-anchored proteins: GPI-anchored proteins in liposomes and cells show similar behavior.

1994 • 688 citations

Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains

1998 • 630 citations

Activation of the Sire-family tyrosine kinase Hck by SH3 domain displacement

1997 • 601 citations

Properties of lipid microdomains in a muscle cell membrane visualized by single molecule microscopy

2000 • 572 citations

Cholesterol Is Required for Surface Transport of Influenza Virus Hemagglutinin

1998 • 555 citations

Microdomains of GPI-anchored proteins in living cells revealed by crosslinking

1998 • 555 citations

T cell antigen receptor signal transduction: A tale of tails and cytoplasmic protein-tyrosine kinases

1993 • 552 citations

The when and how of Src regulation

1993 • 543 citations

Sphingolipid organization in biomembranes: what physical studies of model membranes reveal

1998 • 484 citations

Effects of cholesterol depletion by cyclodextrin on the sphingolipid microdomains of the plasma membrane

1998 • 467 citations

Revisiting the Fluid Mosaic Model of Membranes

1995 • 457 citations

Inhibition of Protein Palmitoylation, Raft Localization, and T Cell Signaling by 2-Bromopalmitate and Polyunsaturated Fatty Acids

2000 • 452 citations

Switching Signals On or Off by Receptor Dimerization

1998 • 428 citations

Cholesterol and Sphingolipid Enhance the Triton X-100 Insolubility of Glycosylphosphatidylinositol-anchored Proteins by Promoting the Formation of Detergent-insoluble Ordered Membrane Domains

1998 • 415 citations

Looking at lipid rafts?

1999 • 406 citations

Analysis of Cd44-Containing Lipid Rafts

1999 • 399 citations

Making the T Cell Receptor Go the Distance: A Topological View of T Cell Activation

1997 • 399 citations

A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor

1997 • 397 citations

S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes

1997 • 364 citations

Clusters of glycolipid and glycosylphosphatidylinositol-anchored proteins in lymphoid cells : accumulation of actin regulated by local tyrosine phosphorylation

1999 • 316 citations

Transient Confinement of a Glycosylphosphatidylinositol-Anchored Protein in the Plasma Membrane

1997 • 303 citations

The nature of large noncovalent complexes containing glycosyl-phosphatidylinositol-anchored membrane glycoproteins and protein tyrosine kinases.

1992 • 300 citations

New insights in glycosphingolipid function: "glycosignaling domain," a cell surface assembly of glycosphingolipids with signal transducer molecules, involved in cell adhesion coupled with signaling

1998 • 291 citations

Engagement of GPI-Linked CD48 Contributes to TCR Signals and Cytoskeletal Reorganization

1998 • 278 citations

Phosphatidylinositol membrane anchors and T-cell activation

1991 • 263 citations

Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins.

1993 • 259 citations

Polyunsaturated Fatty Acids Inhibit T Cell Signal Transduction by Modification of Detergent-insoluble Membrane Domains

1998 • 254 citations

Signals determining protein tyrosine kinase and glycosyl-phosphatidylinositol-anchored protein targeting to a glycolipid-enriched membrane fraction.

1994 • 240 citations

VIP17/MAL, a lipid raft-associated protein, is involved in apical transport in MDCK cells

1999 • 203 citations

The tyrosine kinase connection: how GPI-anchored proteins activate T cells

1993 • 198 citations

Interaction of Proteins With Lipid Headgroups: Lessons from Protein Kinase C

1993 • 184 citations

Proline Residues in Cd28 and the Src Homology (Sh)3 Domain of Lck Are Required for T Cell Costimulation

1999 • 180 citations

SIGNALING COMPLEXES:Biophysical Constraints on Intracellular Communication

1998 • 172 citations

Structural Mosaicism on the Submicron Scale in the Plasma Membrane

1998 • 166 citations

Thy-1-mediated T-cell activation requires co-expression of CD3/Ti complex

1987 • 159 citations

Glycosphingolipids Are Not Essential for Formation of Detergent-resistant Membrane Rafts in Melanoma Cells

1999 • 159 citations

Rapid Redistribution of CD20 to a Low Density Detergent-insoluble Membrane Compartment

1998 • 150 citations

CD44 Selectively Associates With Active Src Family Protein Tyrosine Kinases Lck and Fyn in Glycosphingolipid-Rich Plasma Membrane Domains of Human Peripheral Blood Lymphocytes

1998 • 148 citations

Microdomain-dependent Regulation of Lck and Fyn Protein-Tyrosine Kinases in T Lymphocyte Plasma Membranes

1999 • 136 citations

Microdomains in lymphocyte signalling: beyond GPI-anchored proteins

2000 • 135 citations

A Balance between Positive and Negative Signals in Cytotoxic Lymphocytes Regulates the Polarization of Lipid Rafts during the Development of Cell-Mediated Killing

2000 • 134 citations

Interactions between GPI-anchored proteins and membrane lipids

1992 • 124 citations

Cutting Edge: TCR Signaling Induces Selective Exclusion of CD43 from the T Cell-Antigen-Presenting Cell Contact Site

1998 • 123 citations

Antigen-Mediated IGE Receptor Aggregation and Signaling: A Window on Cell Surface Structure and Dynamics

1996 • 120 citations

TAP transcription and phosphatidylinositol linkage mutants are defective in activation through the T cell receptor

1988 • 112 citations

Dual Fatty Acylation of p59Fyn Is Required for Association with the T Cell Receptor ζ Chain through Phosphotyrosine–Src Homology Domain-2 Interactions

1999 • 105 citations

Thy-1- and Ly-6-mediated lymphokine production and growth inhibition of a T cell hybridoma require co-expression of the T cell antigen receptor complex.

1988 • 103 citations

Crippling of CD3-ζ ITAMs Does Not Impair T Cell Receptor Signaling

1999 • 100 citations

MAL, an Integral Element of the Apical Sorting Machinery, Is an Itinerant Protein That Cycles between theTrans-Golgi Network and the Plasma Membrane

1999 • 96 citations

Signals Determining Protein Tyrosine Kinase and Glycosyl-Phosphatidylinositol-Anchored Protein Targeting to a Glycolipid-Enriched Membrane Fraction

1994 • 88 citations

MAL, a novel integral membrane protein of human T lymphocytes, associates with glycosylphosphatidylinositol-anchored proteins and Src-like tyrosine kinases

1998 • 73 citations

Palmitylation of an Amino-Terminal Cysteine Motif of Protein Tyrosine Kinases p56^lckand p59^fynMediates Interaction With Glycosyl-Phosphatidylinositol-Anchored Proteins

1993 • 66 citations

Association of specific cell-surface glycoproteins with a triton X-100-resistant complex of plasma membrane proteins isolated from T-lymphoma cells (P 1798)

1985 • 62 citations

High Concentration of the EBV Latent Membrane Protein 1 in Glycosphingolipid-Rich Complexes from both Epithelial and Lymphoid Cells

1997 • 51 citations

Differential Regulation of Src-Family Protein Tyrosine Kinases in GPI Domains of T Lymphocyte Plasma Membranes

1996 • 47 citations

Phosphatidylinositol-based glycolipid-anchored proteins enhance proximal TCR signaling events.

1997 • 44 citations

Activation of T cells via CD55: recruitment of early components of the CD3-TCR pathway is required for IL-2 secretion.

1998 • 39 citations

Distinct interactions among GPI-anchored, transmembrane and membrane associated intracellular proteins, and sphingolipids in lymphocyte and endothelial cell plasma membranes

1997 • 33 citations

Immobilization of glycosylphosphatidylinositol-anchored proteins inhibits T cell growth but not function

1999 • 31 citations

Incorporation of MAL, an Integral Protein Element of the Machinery for the Glycolipid and Cholesterol-Mediated Apical Pathway of Transport, into Artificial Membranes Requires Neither of These Lipid Species

1999 • 9 citations

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