Assessing Tumor Progression Factors by Somatic Gene Transfer into a Mouse Model: Bcl-xL Promotes Islet Tumor Cell Invasion

The Hallmarks of Cancer

2000 • 27,569 citations

Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring

1999 • 11,586 citations

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Cell Migration: Integrating Signals from Front to Back

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The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression

2000 • 3,504 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Tumour-cell invasion and migration: diversity and escape mechanisms

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The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells

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TGF-β signaling in tumor suppression and cancer progression

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Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation

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The Bcl-2 apoptotic switch in cancer development and therapy

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The multistep nature of cancer

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BCL-2 FAMILY: Regulators of Cell Death

1998 • 1,687 citations

Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer

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A causal role for E-cadherin in the transition from adenoma to carcinoma

1998 • 1,415 citations

Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

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Isolation and characterization of type IV procollagen, laminin, and heparan sulfate proteoglycan from the EHS sarcoma

1982 • 1,225 citations

Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak

2007 • 1,110 citations

Bcl-2 initiates a new category of oncogenes: regulators of cell death

1992 • 1,078 citations

Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.

1993 • 1,044 citations

Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness

1994 • 1,018 citations

Myosins: a diverse superfamily

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Inducible Gene Targeting in Mice Using the Cre/loxSystem

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Adaptor plasmids simplify the insertion of foreign DNA into helper-independent retroviral vectors

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Unconventional Myosins in Cell Movement, Membrane Traffic, and Signal Transduction

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Suppression of Myc-Induced Apoptosis in β Cells Exposes Multiple Oncogenic Properties of Myc and Triggers Carcinogenic Progression

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Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway

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Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene.

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bcl-xLx is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria

1994 • 435 citations

Bcl-XL and Bcl-2 repress a common pathway of cell death.

1995 • 406 citations

The DF-1 Chicken Fibroblast Cell Line: Transformation Induced by Diverse Oncogenes and Cell Death Resulting from Infection by Avian Leukosis Viruses

1998 • 403 citations

A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis

1994 • 391 citations

Regulation of protrusion, adhesion dynamics, and polarity by myosins IIA and IIB in migrating cells

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Cancer Modeling in the Modern Era

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A receptor for subgroup A Rous sarcoma virus is related to the low density lipoprotein receptor

1993 • 351 citations

Genome scanning with array CGH delineates regional alterations in mouse islet carcinomas

2001 • 305 citations

Conditional mouse models of sporadic cancer

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Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis

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Cadherins regulate aggregation of pancreatic β-cells in vivo

1996 • 233 citations

Overexpression of BCL-x protein in primary breast cancer is associated with high tumor grade and nodal metastases.

1997 • 207 citations

The rise and fall of apoptosis during multistage tumorigenesis: down-modulation contributes to tumor progression from angiogenic progenitors.

1996 • 206 citations

Isolation of a chicken gene that confers susceptibility to infection by subgroup A avian leukosis and sarcoma viruses

1993 • 203 citations

The EV-O-Derived Cell Line DF-1 Supports the Efficient Replication of Avian Leukosis-Sarcoma Viruses and Vectors

1998 • 191 citations

Replication-competent retroviral vectors encoding alkaline phosphatase reveal spatial restriction of viral gene expression/transduction in the chick embryo.

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Function of Myosin-V in Filopodial Extension of Neuronal Growth Cones

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N-linked oligosaccharides are not involved in the function of a cell-cell binding glycoprotein E-cadherin.

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Yph1p, an ORC-Interacting Protein

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Development of a flexible and specific gene delivery system for production of murine tumor models

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Bcl-xL sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers

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The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer

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Profound defects in pancreatic β-cell function in mice with combined heterozygous mutations in Pdx-1 , Hnf-1 α, and Hnf-3 β

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ADictyostelium myosin I plays a crucial role in regulating the frequency of pseudopods formed on the substratum

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An RCAS-TVA-based approach to designer mouse models

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Overexpression of Bcl-xL in Human Breast Cancer Cells Enhances Organ-Selective Lymph Node Metastasis

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Conditional animal models: a strategy to define when oncogenes will be effective targets to treat cancer

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Spatiotemporal expression of catenins, ZO-1, and occludin during early polarization of hepatic WIF-B9 cells

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Tumor Cells Utilize Multiple Pathways to Down‐modulate Apoptosis: Lessons from a Mouse Model of Islet Cell Carcinogenesis

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Demonstration of expanding cell populations in mouse pancreatic acini and islets

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Oncogene Expression and Genetic Background Influence the Frequency of DNA Copy Number Abnormalities in Mouse Pancreatic Islet Cell Carcinomas

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