Metabotropic glutamate receptors: new targets for the control of tumor growth?

Stem cells, cancer, and cancer stem cells

2001 • 9,488 citations

Identification of human brain tumour initiating cells

2004 • 7,166 citations

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

2006 • 6,005 citations

The versatility and universality of calcium signalling

2000 • 5,407 citations

Identification and expansion of human colon-cancer-initiating cells

2006 • 3,914 citations

Subventricular Zone Astrocytes Are Neural Stem Cells in the Adult Mammalian Brain

1999 • 3,822 citations

Tumour stem cells and drug resistance

2005 • 3,535 citations

The mGluR theory of fragile X mental retardation

2004 • 1,540 citations

Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration

2004 • 1,261 citations

Cost of Migration: Invasion of Malignant Gliomas and Implications for Treatment

2003 • 1,150 citations

Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells

2006 • 1,148 citations

Pharmacological agents acting at subtypes of metabotropic glutamate receptors

1999 • 1,055 citations

Modulation of Neuronal Migration by NMDA Receptors

1993 • 1,034 citations

Neural Stem Cells and the Origin of Gliomas

2005 • 1,027 citations

Brain tumour stem cells

2006 • 974 citations

GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain

2004 • 963 citations

Metabotropic glutamate receptors as novel targets for anxiety and stress disorders

2005 • 593 citations

Glutamate release promotes growth of malignant gliomas

2001 • 556 citations

Somatic mutations of PTEN in glioblastoma multiforme.

1997 • 526 citations

Glioma cells release excitotoxic concentrations of glutamate.

1999 • 420 citations

Transcription factors in glutamatergic neurogenesis: Conserved programs in neocortex, cerebellum, and adult hippocampus

2006 • 417 citations

Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer

2001 • 397 citations

PTEN gene mutations are seen in high-grade but not in low-grade gliomas.

1997 • 383 citations

Compromised Glutamate Transport in Human Glioma Cells: Reduction–Mislocalization of Sodium-Dependent Glutamate Transporters and Enhanced Activity of Cystine–Glutamate Exchange

1999 • 339 citations

Metabotropic Glutamate Receptor Subtypes as Targets for Neuroprotective Drugs

2001 • 310 citations

Recent Advances in the Treatment of Malignant Astrocytoma

2006 • 309 citations

Metabotropic glutamate receptors in the basal ganglia motor circuit

2005 • 308 citations

Blockage of Ca2+-permeable AMPA receptors suppresses migration and induces apoptosis in human glioblastoma cells

2002 • 307 citations

Molecular determinants of metabotropic glutamate receptor signaling

2001 • 307 citations

Glutamate signalling in non-neuronal tissues

2001 • 298 citations

Medulloblastoma: signalling a change in treatment

2004 • 294 citations

Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteins

2003 • 289 citations

Control of calcium oscillations by phosphorylation of metabotropic glutamate receptors

1996 • 289 citations

Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia

2003 • 286 citations

Glutamate antagonists limit tumor growth

2001 • 270 citations

The ups and downs of addiction: role of metabotropic glutamate receptors

2004 • 220 citations

The role of N‐methyl‐<scp>D</scp>‐asparate receptors in neurogenesis

2006 • 180 citations

Metabotropic Glutamate Receptor Involvement in Models of Acute and Persistent Pain: Prospects for the Development of Novel Analgesics

2002 • 153 citations

Glutamate enhances survival and proliferation of neural progenitors derived from the subventricular zone

2005 • 149 citations

Endogenous activation of metabotropic glutamate receptors supports the proliferation and survival of neural progenitor cells

2005 • 129 citations

Activation of Metabotropic Glutamate Receptor mGlu5 on Nuclear Membranes Mediates Intranuclear Ca2+ Changes in Heterologous Cell Types and Neurons

2003 • 129 citations

Malignant gliomas: perverting glutamate and ion homeostasis for selective advantage

2003 • 124 citations

Metabotropic Glutamate Receptor 4 Expression in Colorectal Carcinoma and Its Prognostic Significance

2005 • 123 citations

Glutamate as a Modulator of Embryonic and Adult Neurogenesis

2006 • 121 citations

Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo

2005 • 107 citations

[Tumor stem cells and drug resistance].

2007 • 106 citations

Metabotropic glutamate receptors as a strategic target for the treatment of epilepsy

2006 • 104 citations

Cellular and Molecular Mechanisms of Cerebellar Granule Cell Migration

2002 • 96 citations

Brain-tumour drug resistance: the bare essentials

2002 • 96 citations

Opposite influence of the metabotropic glutamate receptor subtypes mGlu3 and -5 on astrocyte proliferation in culture

1997 • 96 citations

The Excitatory Amino Acid Transporter-2 Induces Apoptosis and Decreases Glioma Growth In vitro and In vivo

2005 • 89 citations

Pharmacological blockade of mGlu2/3 metabotropic glutamate receptors reduces cell proliferation in cultured human glioma cells

2003 • 83 citations

Stimulation of oncogenic metabotropic glutamate receptor 1 in melanoma cells activates ERK1/2 via PKCε

2005 • 82 citations

Group I metabotropic glutamate receptors reduce excitotoxic injury and may facilitate neurogenesis

2005 • 78 citations

Functional metabotropic glutamate receptors are expressed in oligodendrocyte progenitor cells

2003 • 77 citations

Neoplastic stem cells: A novel therapeutic target in clinical oncology

2006 • 77 citations

Pharmacological Activation of mGlu4 Metabotropic Glutamate Receptors Inhibits the Growth of Medulloblastomas

2006 • 74 citations

Linking DNA damage to medulloblastoma tumorigenesis in patched heterozygous knockout mice

2005 • 72 citations

Metabotropic Glutamate Receptor 4-Mediated 5-Fluorouracil Resistance in a Human Colon Cancer Cell Line

2004 • 70 citations

PHCCC, a Specific Enhancer of Type 4 Metabotropic Glutamate Receptors, Reduces Proliferation and Promotes Differentiation of Cerebellar Granule Cell Neuroprecursors

2004 • 62 citations

Expression of functional mGlu5 metabotropic glutamate receptors in human melanocytes

2000 • 53 citations

Endogenous activation of mGlu5 metabotropic glutamate receptors supports self-renewal of cultured mouse embryonic stem cells

2005 • 52 citations

Group I metabotropic glutamate receptors limit AMPA receptor-mediated oligodendrocyte progenitor cell death

2001 • 33 citations

Endogenously activated mGlu5 metabotropic glutamate receptors sustain the increase in c‐Myc expression induced by leukaemia inhibitory factor in cultured mouse embryonic stem cells

2006 • 32 citations

Metabotropic glutamate receptors are expressed in adult human glial progenitor cells

2004 • 27 citations

Recent advances in positive allosteric modulators of metabotropic glutamate receptors.

2005 • 27 citations

Context-dependent regulation of embryonic stem cell differentiation by mGlu4 metabotropic glutamate receptors

2006 • 25 citations

Recent advances in the treatment of APL.

2006 • 14 citations

Metabotropic glutamate receptors as targets for neuroprotective drugs

2000 • 3 citations