Tumor progression induced by the loss of E-cadherin independent of β-catenin/Tcf-mediated Wnt signaling

Epithelial–mesenchymal transitions in tumour progression

2002 • 6,431 citations

Wnt signalling in stem cells and cancer

2005 • 3,593 citations

Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC ^−/− Colon Carcinoma

1997 • 3,234 citations

Convergence of Wnt, ß-Catenin, and Cadherin Pathways

2004 • 2,451 citations

Molecular requirements for epithelial–mesenchymal transition during tumor progression

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Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role

1991 • 1,686 citations

A causal role for E-cadherin in the transition from adenoma to carcinoma

1998 • 1,415 citations

Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

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Cell adhesion and signalling by cadherins and Ig-CAMs in cancer

2004 • 1,270 citations

Intestinal polyposis in mice with a dominant stable mutation of the beta -catenin gene

1999 • 1,161 citations

De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin

1998 • 1,082 citations

Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion.

1989 • 961 citations

The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene

1999 • 738 citations

Mutations in the APC tumour suppressor gene cause chromosomal instability

2001 • 722 citations

Sticky Business

2003 • 709 citations

Overexpression of cadherins and underexpression of ?-catenin inhibit dorsal mesoderm induction in early Xenopus embryos

1994 • 647 citations

Balancing cell adhesion and Wnt signaling, the key role of β-catenin

2005 • 636 citations

Tumor invasion in the absence of epithelial-mesenchymal transition: Podoplanin-mediated remodeling of the actin cytoskeleton

2006 • 584 citations

E-Cadherin Suppresses Cellular Transformation by Inhibiting β-Catenin Signaling in an Adhesion-Independent Manner

2001 • 532 citations

E-cadherin binding prevents β-catenin nuclear localization and β-catenin/LEF-1-mediated transactivation

1999 • 526 citations

An HMG-box-containing T-cell factor required for thymocyte differentiation

1995 • 518 citations

Uncoupling cadherin-based adhesion from wingless signalling in Drosophila

1996 • 365 citations

E-cadherin regulates cell growth by modulating proliferation-dependent β-catenin transcriptional activity

2001 • 328 citations

Distinct molecular forms of β-catenin are targeted to adhesive or transcriptional complexes

2004 • 310 citations

Emerging roles for p120-catenin in cell adhesion and cancer

2004 • 280 citations

Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of beta-catenin.

2002 • 157 citations

Mutant E-cadherin breast cancer cells do not display constitutive Wnt signaling.

2001 • 151 citations

Beta- and gamma-catenin mutations, but not E-cadherin inactivation, underlie T-cell factor/lymphoid enhancer factor transcriptional deregulation in gastric and pancreatic cancer.

1999 • 142 citations

Intestinal dysplasia and adenoma in transgenic mice after overexpression of an activated beta-catenin.

1999 • 115 citations

Pancreatic beta cells cultured from individual preneoplastic foci in a multistage tumorigenesis pathway: a potentially general technique for isolating physiologically representative cell lines.

1993 • 102 citations

Loss of Neural Cell Adhesion Molecule Induces Tumor Metastasis by Up-regulating Lymphangiogenesis

2004 • 90 citations

E-cadherin modulates Wnt-dependent transcription in colorectal cancer cells but does not alter Wnt-independent gene expression in fibroblasts

2006 • 74 citations

An Unexpected Role for p53 in Augmenting SV40 Large T Antigen-Mediated Tumorigenesis

1999 • 26 citations