Cancer cell lines release glutamate into the extracellular environment

Skeletal complications of malignancy

1997 • 1,450 citations

Glioma cells release excitotoxic concentrations of glutamate.

1999 • 420 citations

Autocrine Glutamate Signaling Promotes Glioma Cell Invasion

2007 • 313 citations

Inhibition of Cystine Uptake Disrupts the Growth of Primary Brain Tumors

2005 • 302 citations

Glutamate signalling in non-neuronal tissues

2001 • 298 citations

The bone microenvironment in metastasis; what is special about bone?

2007 • 282 citations

Glutamate antagonists limit tumor growth

2001 • 270 citations

Evidence for a dense and intimate innervation of the bone tissue, including glutamate-containing fibers

1999 • 249 citations

Glutamate Receptors Are Expressed by Bone Cells and Are Involved in Bone Resorption

1998 • 237 citations

Glutamate signaling in peripheral tissues

2003 • 233 citations

Mechanically regulated expression of a neural glutamate transporter in bone: A role for excitatory amino acids as osteotropic agents?

1997 • 214 citations

Expression of an N-Methyl-D-Aspartate-Type Receptor by Human and Rat Osteoblasts and Osteoclasts Suggests a Novel Glutamate Signaling Pathway in Bone

1998 • 176 citations

Human cystine/glutamate transporter: cDNA cloning and upregulation by oxidative stress in glioma cells

2001 • 142 citations

A mechanism for glutamate toxicity in the C6 glioma cells involving inhibition of cystine uptake leading to glutathione depletion

1992 • 135 citations

Malignant gliomas: perverting glutamate and ion homeostasis for selective advantage

2003 • 124 citations

Doxycycline decreases tumor burden in a bone metastasis model of human breast cancer.

2002 • 120 citations

Cell-to-cell interactions in bone

2004 • 118 citations

Functional characterization of N-methyl-d-aspartic acid-gated channels in bone cells

1999 • 103 citations

Modulation of cellular differentiation by N ‐methyl‐ <scp>d</scp> ‐aspartate receptors in osteoblasts

2003 • 100 citations

Determinants of glutamine dependence and utilization by normal and tumor-derived breast cell lines

1998 • 92 citations

Nitrogen movement between host and tumor in mice inoculated with Ehrlich ascitic tumor cells.

1984 • 90 citations

Evidence for targeted vesicular glutamate exocytosis in osteoblasts

2001 • 88 citations

Secretion of L-glutamate from osteoclasts through transcytosis

2006 • 85 citations

Regulation of spontaneous glutamate release activity in osteoblastic cells and its role in differentiation and survival: evidence for intrinsic glutamatergic signaling in bone

2001 • 85 citations

Glutamate antagonists limit tumor growth

2002 • 84 citations

Pathophysiologic interactions in skeletal metastasis

2000 • 82 citations

N-Methyl-D-Aspartate Receptor in Human Prostate Cancer

2005 • 74 citations

NMDA glutamate receptors are expressed by osteoclast precursors and involved in the regulation of osteoclastogenesis

2003 • 68 citations

Presence of NMDA Receptor Subunits in the Male Lower Urogenital Tract

2000 • 66 citations

Glutamate Signaling System in Bone

2004 • 65 citations

The NMDA Type Glutamate Receptors Expressed by Primary Rat Osteoblasts Have the Same Electrophysiological Characteristics as Neuronal Receptors

2002 • 58 citations

Mechanical loading modulates glutamate receptor subunit expression in bone

2005 • 57 citations

Glutamatergic innervation in bone

2002 • 55 citations

EAAC1 is expressed in rat and human prostate epithelial cells; functions as a high-affinity L-aspartate transporter; and is regulated by prolactin and testosterone

2006 • 54 citations

The role of glutamate in the regulation of bone mass and architecture.

2008 • 54 citations

The amino acid requirements of the Walker carcinosarcoma 256 in vitro.

1956 • 54 citations

Breast cancer-derived factors facilitate osteolytic bone metastasis.

2006 • 52 citations

Demonstration of expression of mRNA for particular AMPA and kainate receptor subunits in immature and mature cultured rat calvarial osteoblasts

2002 • 47 citations

Proteases, growth factors, chemokines, and the microenvironment in prostate cancer bone metastasis

2007 • 47 citations

Effect of zoledronic acid on the doxycycline-induced decrease in tumour burden in a bone metastasis model of human breast cancer

2007 • 38 citations

Long-term potentiation in bone--a role for glutamate in strain-induced cellular memory?

2003 • 34 citations

Pharmacological Topics of Bone Metabolism: Glutamate as a Signal Mediator in Bone

2008 • 34 citations

BMP-7 and Excess Glutamate: Opposing Effects on Dendrite Growth from Cerebral Cortical Neurons in Vitro

2002 • 32 citations

Regulation of the mGluR5, EAAT1 and GS expression by glucocorticoids in MG-63 osteoblast-like osteosarcoma cells.

2007 • 27 citations

Morphological, histomorphometric, and microstructural alterations in human bone metastasis from breast carcinoma

2002 • 22 citations

Glutamatergic regulation of bone remodeling.

2002 • 21 citations

Molecular physiology of vesicular glutamate transporters in the digestive system

2005 • 20 citations

Taxol induced apoptosis regulates amino acid transport in breast cancer cells

2006 • 19 citations

Glutamatergic regulation of bone resorption.

2002 • 18 citations

'Pre-synaptic' vesicular glutamate release mechanisms in osteoblasts.

2003 • 11 citations

Functional osteoblastic ionotropic glutamate receptors are a prerequisite for bone formation.

2002 • 11 citations