Identification of a Proline-Rich Sequence in the CD2 Cytoplasmic Domain Critical for Regulation of Integrin-Mediated Adhesion and Activation of Phosphoinositide 3-Kinase

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Adhesion receptors of the immune system

1990 • 6,585 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

VLA Proteins in the Integrin Family: Structures, Functions, and Their Role on Leukocytes

1990 • 1,592 citations

Integrins: Emerging Paradigms of Signal Transduction

1995 • 1,591 citations

T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

1989 • 1,587 citations

Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

1997 • 1,448 citations

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

1997 • 1,162 citations

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses

1993 • 1,148 citations

An alternative pathway of T-cell activation: A functional role for the 50 kd T11 sheep erythrocyte receptor protein

1984 • 1,132 citations

Modular binding domains in signal transduction proteins

1995 • 962 citations

T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-lβ

1993 • 896 citations

Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

1991 • 785 citations

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

1994 • 728 citations

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

1996 • 713 citations

Phosphatidylinositol 3-kinase: Structure and expression of the 110 kd catalytic subunit

1992 • 692 citations

Cloning and Characterization of a G Protein-Activated Human Phosphoinositide-3 Kinase

1995 • 673 citations

Linkage of G Protein-Coupled Receptors to the MAPK Signaling Pathway Through PI 3-Kinase γ

1997 • 671 citations

Integrin-mediated cell adhesion activates mitogen-activated protein kinases.

1994 • 660 citations

Phosphatidylinositol 3‐kinase

1994 • 649 citations

Regulated expression and binding of three VLA (β1) integrin receptors on T cells

1990 • 634 citations

Activation of Phosphoinositide 3-OH Kinase by the α6β4 Integrin Promotes Carcinoma Invasion

1997 • 615 citations

A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits

1994 • 597 citations

Ras-Dependent Induction of Cellular Responses by Constitutively Active Phosphatidylinositol-3 Kinase

1995 • 553 citations

Phosphoinositide kinases

1996 • 529 citations

Suppression of Integrin Activation: A Novel Function of a Ras/Raf-Initiated MAP Kinase Pathway

1997 • 501 citations

Enhancement of LFA-1-mediated cell adhesion by triggering through CD2 or CD3 on T lymphocytes

1989 • 482 citations

A Specific Product of Phosphatidylinositol 3-Kinase Directly Activates the Protein Kinase Akt through Its Pleckstrin Homology Domain

1997 • 481 citations

The dynamic regulation of integrin adhesiveness

1994 • 456 citations

Regulation of the fibronectin receptor affinity by divalent cations.

1988 • 441 citations

αLβ2 Integrin/LFA-1 Binding to ICAM-1 Induced by Cytohesin-1, a Cytoplasmic Regulatory Molecule

1996 • 439 citations

Phosphatidylinositol 3-Kinase Is Required for Integrin-Stimulated AKT and Raf-1/Mitogen-Activated Protein Kinase Pathway Activation

1997 • 433 citations

p110δ, a novel phosphoinositide 3-kinase in leukocytes

1997 • 417 citations

Signaling by Phosphoinositide-3,4,5-Trisphosphate Through Proteins Containing Pleckstrin and Sec7 Homology Domains

1997 • 405 citations

The structure and ligand interactions of CD2: implications for T-cell function

1996 • 397 citations

CD31 expressed on distinctive T cell subsets is a preferential amplifier of beta 1 integrin-mediated adhesion.

1992 • 383 citations

Activation of cytolytic T lymphocyte and natural killer cell function through the T11 sheep erythrocyte binding protein

1985 • 287 citations

The proto-oncogene product p120CBL and the adaptor proteins CRKL and c-CRK link c-ABL, p190BCR/ABL and p210BCR/ABL to the phosphatidylinositol-3' kinase pathway.

1996 • 259 citations

Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85.

1993 • 259 citations

Wortmannin and Its Structural Analogue Demethoxyviridin Inhibit Stimulated Phospholipase A2 Activity in Swiss 3T3 Cells

1995 • 252 citations

Alternative pathway activation of T cells by binding of CD2 to its cell-surface ligand

1987 • 251 citations

Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells.

1995 • 237 citations

The Structure and Function of P55^PIK Reveal a New Regulatory Subunit for Phosphatidylinositol 3-Kinase

1995 • 235 citations

Regulation of the VLA integrin-ligand interactions through the beta 1 subunit.

1992 • 214 citations

Chemokines regulate T cell adherence to recombinant adhesion molecules and extracellular matrix proteins.

1996 • 211 citations

A monoclonal antibody to beta 1 integrin (CD29) stimulates VLA-dependent adherence of leukocytes to human umbilical vein endothelial cells and matrix components.

1992 • 205 citations

Crosslinking of the T cell-specific accessory molecules CD7 and CD28 modulates T cell adhesion.

1992 • 194 citations

PI 3-kinase: a pivotal pathway in T-cell activation?

1996 • 188 citations

Investigation of neutrophil signal transduction using a specific inhibitor of phosphatidylinositol 3-kinase.

1995 • 184 citations

Calcium dependency of antigen-specific (T3-Ti) and alternative (T11) pathways of human T-cell activation.

1984 • 175 citations

Activation of human thymocytes via the 50KD T11 sheep erythrocyte binding protein induces the expression of interleukin 2 receptors on both T3+ and T3- populations.

1985 • 170 citations

Regulatory recruitment of signalling molecules to the cell membrane by pleckstrinhomology domains

1997 • 155 citations

Interleukin-2 Triggers a Novel Phosphatidylinositol 3-Kinase-Dependent MEK Activation Pathway

1995 • 145 citations

Transmembrane signalling via the T11‐dependent pathway of human T cell activation. Evidence for the involvement of 1,2‐diacylglycerol and inositol phosphates

1987 • 137 citations

The CD2 ligand LFA-3 activates T cells but depends on the expression and function of the antigen receptor.

1988 • 131 citations

A Novel 55-kDa Regulatory Subunit for Phosphatidylinositol 3-Kinase Structurally Similar to p55PIK Is Generated by Alternative Splicing of the p85α Gene

1996 • 119 citations

Regulating integrin-mediated adhesion: one more function for PI 3-kinase?

1996 • 115 citations

A role for phosphatidylinositol 3-kinase in the regulation of beta 1 integrin activity by the CD2 antigen.

1995 • 111 citations

CD28-mediated up-regulation of beta 1-integrin adhesion involves phosphatidylinositol 3-kinase.

1996 • 102 citations

Activation of tyrosine phosphorylation in human T cells via the CD2 pathway. Regulation by the CD45 tyrosine phosphatase.

1990 • 87 citations

The SH3 domain of p56lck binds to proline-rich sequences in the cytoplasmic domain of CD2.

1996 • 84 citations

Wortmannin Inhibits Mitogen-activated Protein Kinase Activation by Platelet-activating Factor through a Mechanism Independent of p85/p110-type Phosphatidylinositol 3-Kinase

1996 • 84 citations

Inhibition of Phosphatidylinositol 3‐Kinase Blocks T Cell Antigen Receptor/CD3‐Induced Activation of the Mitogen‐Activated Kinase Erk2

1996 • 72 citations

The tyrosine kinase activity of p56^lck is increased in human T cells activated via CD2

1991 • 67 citations

Cloning of a Novel, Ubiquitously Expressed Human Phosphatidylinositol 3-Kinase and Identification of Its Binding Site on p85

1993 • 66 citations

CD7-mediated regulation of integrin adhesiveness on human T cells involves tyrosine phosphorylation-dependent activation of phosphatidylinositol 3-kinase.

1997 • 63 citations

CD2 antigen mediated activation of the guanine nucleotide binding proteins p21ras in human T lymphocytes.

1991 • 60 citations

Distinct divalent cation requirements for integrin-mediated CD4+ T lymphocyte adhesion to ICAM-1, fibronectin, VCAM-1, and invasin.

1993 • 58 citations

Dissection of the human CD2 intracellular domain. Identification of a segment required for signal transduction and interleukin 2 production.

1989 • 57 citations

Phosphatidylinositol 3-OH Kinase Activity Is Not Required for Activation of Mitogen-activated Protein Kinase by Cytokines

1996 • 57 citations

T cell adhesion, avidity regulation and signaling: a molecular analysis of CD2

1993 • 56 citations

Differential activation-dependent regulation of integrin function in cultured human T-leukemic cell lines

1994 • 54 citations

A distinct cytoplasmic domain of CD2 regulates ligand avidity and T-cell responsiveness to antigen.

1992 • 51 citations

Activation and Nuclear Translocation of Mitogen-activated Protein Kinases by Polyomavirus Middle-T or Serum Depend on Phosphatidylinositol 3-Kinase

1995 • 46 citations

Signal transduction pathways involved in T cell receptor-induced regulation of CD2 avidity for CD58.

1993 • 43 citations

CD2 singnaling in T cells involves tyrosine phosphorylation and activation of the Tec family kinase, EMT/ITK/TSK

1996 • 42 citations

Alpha 4 beta 1 integrin-mediated tyrosine phosphorylation in human T cells: characterization of Crk- and Fyn-associated substrates (pp105, pp115, and human enhancer of filamentation-1) and integrin-dependent activation of p59fyn1.

1997 • 40 citations

Separable portions of the CD2 cytoplasmic domain involved in signaling and ligand avidity regulation.

1993 • 36 citations

Interaction of CD2 with its ligand lymphocyte function-associated antigen-3 induces adenosine 3',5'-cyclic monophosphate production in T lymphocytes.

1991 • 34 citations

Involvement of the PPPGHR motif in T cell activation via CD2.

1990 • 34 citations

T cell activation via the CD2 molecule is associated with protein kinase C translocation from the cytosol to the plasma membrane

1989 • 32 citations

Inhibition of MG-63 cell proliferation and PDGF-stimulated cellular processes by inhibitors of phosphatidylinositol 3-kinase

1997 • 32 citations

Activation of MAP-2 kinase activity by the CD2 receptor in Jurkat T cells can be reversed by CD45 phosphatase.

1991 • 26 citations

Tyrosine kinase activity associated with the CD7 antigen: correlation with regulation of T cell integrin function

1994 • 26 citations

Recruitment of Activated p56 on Endosomes of CD2-triggered T Cells, Colocalization with ZAP-70

1996 • 26 citations

T cell receptor-independent CD2 signal transduction in FcR+ cells.

1991 • 25 citations

Regulatory mechanisms underlying T cell integrin receptor function

1993 • 20 citations

Integrins, Integrin Regulators, and the Extracellular Matrix

2020 • 2 citations