Phosphatidylinositol 3-OH Kinase Activity Is Not Required for Activation of Mitogen-activated Protein Kinase by Cytokines

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor

1995 • 1,400 citations

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses

1993 • 1,148 citations

DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

1995 • 742 citations

Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase.

1994 • 678 citations

Ras-Dependent Induction of Cellular Responses by Constitutively Active Phosphatidylinositol-3 Kinase

1995 • 553 citations

The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf

1994 • 476 citations

Involvement of ras p21 protein in signal-transduction pathways from interleukin 2, interleukin 3, and granulocyte/macrophage colony-stimulating factor, but not from interleukin 4.

1991 • 351 citations

Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase

1995 • 277 citations

Transient increase in phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol trisphosphate during activation of human neutrophils

1989 • 256 citations

Wortmannin and Its Structural Analogue Demethoxyviridin Inhibit Stimulated Phospholipase A2 Activity in Swiss 3T3 Cells

1995 • 252 citations

Multiple Independent Inputs Are Required for Activation of the p70 S6 Kinase

1995 • 234 citations

p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein.

1992 • 213 citations

Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation.

1995 • 208 citations

Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase

1994 • 204 citations

IL-4 activates a distinct signal transduction cascade from IL-3 in factor-dependent myeloid cells.

1992 • 191 citations

Investigation of neutrophil signal transduction using a specific inhibitor of phosphatidylinositol 3-kinase.

1995 • 184 citations

Rapamycin, Wortmannin, and the Methylxanthine SQ20006 Inactivate p70s6k by Inducing Dephosphorylation of the Same Subset of Sites

1995 • 168 citations

Activation of p70s6k is associated with phosphorylation of four clustered sites displaying Ser/Thr-Pro motifs.

1992 • 166 citations

Activation of pp70/85 S6 Kinases in Interleukin-2-Responsive Lymphoid Cells Is Mediated by Phosphatidylinositol 3-Kinase and Inhibited by Cyclic AMP

1995 • 164 citations

Multiple cytokines activate phosphatidylinositol 3-kinase in hemopoietic cells. Association of the enzyme with various tyrosine-phosphorylated proteins.

1994 • 159 citations

Multiple hemopoietic growth factors stimulate activation of mitogen-activated protein kinase family members.

1992 • 147 citations

Phosphatidylinositol 3-kinase functions upstream of Ras and Raf in mediating insulin stimulation of c-fos transcription

1993 • 146 citations

Interleukin-2 Triggers a Novel Phosphatidylinositol 3-Kinase-Dependent MEK Activation Pathway

1995 • 145 citations

Antagonists of Phosphatidylinositol 3-Kinase Block Activation of Several Novel Protein Kinases in Neutrophils

1995 • 127 citations

Wortmannin inhibits mitogen-activated protein kinase activation induced by platelet-activating factor in guinea pig neutrophils.

1994 • 123 citations

G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.

1995 • 122 citations

Role of phosphatidylinositol 3-OH-kinase activity in the inhibition of apoptosis in haemopoietic cells: phosphatidylinositol 3-OH-kinase inhibitors reveal a difference in signalling between interleukin-3 and granulocyte-macrophage colony stimulating factor

1995 • 121 citations

Dissociation of pp70 ribosomal protein S6 kinase from insulin-stimulated glucose transport in 3T3-L1 adipocytes.

1993 • 98 citations

Interleukin-4-dependent proliferation dissociates p44erk-1, p42erk-2, and p21ras activation from cell growth.

1994 • 78 citations

Inhibition of Phosphatidylinositol 3‐Kinase Blocks T Cell Antigen Receptor/CD3‐Induced Activation of the Mitogen‐Activated Kinase Erk2

1996 • 72 citations

On the Mechanism of Cytosolic Phospholipase A2 Activation in CHO Cells Carrying Somatostatin Receptor: Wortmannin-Sensitive Pathway to Activate Mitogen-Activated Protein Kinase

1994 • 52 citations

Selective Inhibition of p70 S6 Kinase Activation by Phosphatidylinositol 3‐Kinase Inhibitors

1995 • 48 citations

Activation and Nuclear Translocation of Mitogen-activated Protein Kinases by Polyomavirus Middle-T or Serum Depend on Phosphatidylinositol 3-Kinase

1995 • 46 citations

Wortmannin inhibits the activation of MAP kinase following vasopressin V1 receptor stimulation

1995 • 33 citations

Wortmannin Inhibits Insulin-Induced Ras and Mitogen-Activated Protein Kinase Activation Related to Adipocyte Differentiation in 3T3-L1 Fibroblasts

1995 • 26 citations