ΔNp73, A Dominant-Negative Inhibitor of Wild-type p53 and TAp73, Is Up-regulated in Human Tumors

Surfing the p53 network

2000 • 6,487 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

Monoallelically Expressed Gene Related to p53 at 1p36, a Region Frequently Deleted in Neuroblastoma and Other Human Cancers

1997 • 1,636 citations

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1993 • 1,445 citations

p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

2000 • 979 citations

p73 is a human p53-related protein that can induce apoptosis

1997 • 951 citations

Oncogenic forms of p53 inhibit p53-regulated gene expression

1992 • 933 citations

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

1999 • 914 citations

Death Signal-induced Localization of p53 Protein to Mitochondria

2000 • 883 citations

p53 functions as a cell cycle control protein in osteosarcomas.

1990 • 774 citations

E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation

1996 • 765 citations

Tumor surveillance via the ARF–p53 pathway

1998 • 735 citations

Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1

1996 • 704 citations

Role for the p53 homologue p73 in E2F-1-induced apoptosis

2000 • 700 citations

p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

1999 • 584 citations

Interaction of c-Abl and p73α and their collaboration to induce apoptosis

1999 • 542 citations

A common polymorphism acts as an intragenic modifier of mutant p53 behaviour

2000 • 514 citations

AIS is an oncogene amplified in squamous cell carcinoma

2000 • 465 citations

An Anti-Apoptotic Role for the p53 Family Member, p73, During Developmental Neuron Death

2000 • 461 citations

Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors.

1995 • 421 citations

p73 Function Is Inhibited by Tumor-Derived p53 Mutants in Mammalian Cells

1999 • 418 citations

Sequence-specific transcriptional activation is essential for growth suppression by p53.

1994 • 412 citations

Human ΔNp73 regulates a dominant negative feedback loop for TAp73 and p53

2001 • 335 citations

Oncogenic Forms of p53 Inhibit p53-Regulated Gene Expression

1992 • 333 citations

A common E2F-1 and p73 pathway mediates cell death induced by TCR activation

2000 • 326 citations

The potential tumor suppressor p73 differentially regulates cellular p53 target genes.

1998 • 324 citations

DNA Damage-Dependent Acetylation of p73 Dictates the Selective Activation of Apoptotic Target Genes

2002 • 319 citations

p53: a transdominant regulator of transcription whose function is ablated by mutations occurring in human cancer.

1992 • 278 citations

p53 Functions as a Cell Cycle Control Protein in Osteosarcomas

1990 • 224 citations

Frequent alteration of p63 expression in human primary bladder carcinomas.

2000 • 213 citations

High level expression of ΔN-p63: a mechanism for the inactivation of p53 in undifferentiated nasopharyngeal carcinoma (NPC)?

2000 • 196 citations

Overexpression of the wild type p73 gene in breast cancer tissues and cell lines.

1999 • 190 citations

Possible oncogenic potential of DeltaNp73: a newly identified isoform of human p73.

2002 • 177 citations

Autoinhibitory Regulation of p73 by ΔNp73 To Modulate Cell Survival and Death through a p73-Specific Target Element within the ΔNp73 Promoter

2002 • 173 citations

Transactivation-deficient ΔTA-p73 Inhibits p53 by Direct Competition for DNA Binding

2002 • 171 citations

Oncogenes Induce and Activate Endogenous p73 Protein

2001 • 141 citations

Expression level, allelic origin, and mutation analysis of the p73 gene in neuroblastoma tumors and cell lines.

1998 • 131 citations

Transactivation-deficient p73α (p73Δexon2) inhibits apoptosis and competes with p53

2001 • 121 citations

Cytoplasmically sequestered wild-type p53 protein in neuroblastoma is relocated to the nucleus by a C-terminal peptide

1996 • 119 citations

p53, p63 and p73 – solos, alliances and feuds among family members

2001 • 116 citations

Overexpression of theMDM2Oncogene in Leukemia and Lymphoma

1996 • 78 citations

DNA alterations in cancer : genetic and epigenetic changes

2000 • 73 citations

Analysis of p73 in human borderline and invasive ovarian tumor

2000 • 67 citations

Identification of a Sequence Element from p53 That Signals for Mdm2-Targeted Degradation

2000 • 62 citations

p73 is over-expressed in vulval cancer principally as the Δ2 isoform

2001 • 47 citations

p73 cooperates with DNA damage agents to induce apoptosis in MCF7 cells in a p53-dependent manner

2001 • 41 citations