Human ΔNp73 regulates a dominant negative feedback loop for TAp73 and p53

p53 Mutations in Human Cancers

1991 • 8,133 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

Monoallelically Expressed Gene Related to p53 at 1p36, a Region Frequently Deleted in Neuroblastoma and Other Human Cancers

1997 • 1,636 citations

The p53 pathway

1999 • 1,322 citations

Construction of T-vectors, a rapid and general system for direct cloning of unmodified PCR products

1991 • 1,182 citations

p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

2000 • 979 citations

p73 is a human p53-related protein that can induce apoptosis

1997 • 951 citations

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

1999 • 914 citations

Regulation ofp53downstream genes

1998 • 777 citations

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells.

1996 • 738 citations

Recruitment of p300/CBP in p53-Dependent Signal Pathways

1997 • 671 citations

p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

1999 • 584 citations

The p53/p63/p73 family of transcription factors: overlapping and distinct functions

2000 • 567 citations

Regulation of the p53 Tumor Suppressor Protein

1999 • 566 citations

Interaction of c-Abl and p73α and their collaboration to induce apoptosis

1999 • 542 citations

Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation

1996 • 508 citations

p63 and p73: p53 mimics, menaces and more

2000 • 482 citations

An Anti-Apoptotic Role for the p53 Family Member, p73, During Developmental Neuron Death

2000 • 461 citations

Two New p73 Splice Variants, γ and δ, with Different Transcriptional Activity

1998 • 363 citations

Three distinct signalling responses by murine fibroblasts to genotoxic stress

1996 • 359 citations

The potential tumor suppressor p73 differentially regulates cellular p53 target genes.

1998 • 324 citations

Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5' CpG island methylation.

1999 • 285 citations

Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73

2000 • 238 citations

Neuronal life and death: an essential role for the p53 family

2000 • 201 citations

Loss of p73 gene expression in leukemias/lymphomas due to hypermethylation.

1999 • 191 citations

Induction of Neuronal Differentiation by p73 in a Neuroblastoma Cell Line

2000 • 184 citations

The p53 gene family

1999 • 174 citations

Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain

1999 • 170 citations

New p73 variants with altered C-terminal structures have varied transcriptional activities

1999 • 147 citations

p53 family genes: structural comparison, expression and mutation

1999 • 144 citations

Use of a membrane-localized green fluorescent protein allows simultaneous identification of transfected cells and cell cycle analysis by flow cytometry

1997 • 132 citations

Evolution of Functions within the p53/p63/p73 Family

2000 • 126 citations

Transactivation-deficient p73α (p73Δexon2) inhibits apoptosis and competes with p53

2001 • 121 citations

Structure, function and regulation of p63 and p73

1999 • 118 citations

c-Abl Neutralizes the Inhibitory Effect of Mdm2 on p53

1999 • 104 citations

Regulation and activation of p53 and its family members

1999 • 89 citations

Comparative Analysis of P73 and P53 Regulation and Effector Functions

1999 • 74 citations

Enhanced p73 Expression during Differentiation and Complex p73 Isoforms in Myeloid Leukemia

2000 • 63 citations

Transcriptional dysregulation of the p73L / p63 / p51 / p40 / KET gene in human squamous cell carcinomas: expression of Δ Np73L, a novel dominant-negative isoform, and loss of expression of the potential tumour suppressor p51

2001 • 56 citations

Distinct expression patterns of the p53-homologue p73 in malignant and normal hematopoiesis assessed by a novel real-time reverse transcription-polymerase chain reaction assay and protein analysis.

1999 • 44 citations

Differential expression of p73 splice variants and protein in benign and malignant ovarian tumours

2000 • 40 citations

p73 is not Mutated in Meningiomas as Determined with a Functional Yeast Assay but p73 Expression Increases with Tumor Grade

2001 • 38 citations

Expression of p73 and p63 proteins in pancreatic adenocarcinoma: p73 overexpression is inversely correlated with biological aggressiveness

2001 • 32 citations

P73 mutations and expression in adult de novo acute myelogenous leukemia

1999 • 28 citations

p73 gene alterations and expression in primary oral and laryngeal squamous carcinomas

2001 • 22 citations

P73 EXPRESSION IN NEUROBLASTOMA: A ROLE IN THE BIOLOGY OF ADVANCED TUMORS?

2001 • 3 citations