Roles of insulinlike growth factor 1 (IGF-1) and the IGF-1 receptor in epidermal growth factor-stimulated growth of 3T3 cells.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

1986 • 1,866 citations

[18] Hybridization of denatured RNA transferred or dotted to nitrocellulose paper

1983 • 1,112 citations

Dual control of cell growth by somatomedins and platelet-derived growth factor.

1979 • 926 citations

Plasmid-encoded hygromycin B resistance: the sequence of hygromycin B phosphotransferase gene and its expression in Escherichia coli and Saccharomyces cerevisiae

1983 • 810 citations

Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation.

1990 • 404 citations

Role of insulin-like growth factors and the type I insulin-like growth factor receptor in the estrogen-stimulated proliferation of human breast cancer cells.

1990 • 385 citations

Platelet-derived growth factor and the regulation of the mammalian fibroblast cell cycle

1979 • 374 citations

Transforming potential of the c-fms proto-oncogene (CSF-1 receptor)

1987 • 357 citations

Developmental regulation of the rat insulin-like growth factor I receptor gene.

1989 • 338 citations

Epidermal growth factor (EGF) and somatomedin C regulate G1 progression in competent BALB/c-3T3 cells

1982 • 318 citations

Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts.

1986 • 269 citations

Insulin-like growth factor-I can mediate autocrine proliferation of human small cell lung cancer cell lines in vitro.

1988 • 247 citations

Differential signalling potential of insulin- and IGF-1-receptor cytoplasmic domains.

1989 • 225 citations

Prognostic value of receptors for insulin-like growth factor 1, somatostatin, and epidermal growth factor in human breast cancer.

1989 • 217 citations

Sequences of liver cDNAs encoding two different mouse insulin-like growth factor I precursors

1986 • 215 citations

Receptors for epidermal growth factor and insulin-like growth factor I and their relation to steroid receptors in human breast cancer.

1988 • 208 citations

Insulin-like growth factor 1 receptors in human breast cancer and their relation to estradiol and progesterone receptors.

1988 • 173 citations

Constitutive expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor abrogates all requirements for exogenous growth factors.

1992 • 159 citations

Multiple Hormones Stimulate the Production of Somatomedin by Cultured Human Fibroblasts*

1984 • 143 citations

Inhibition of the mitogenic effects of plasma by a monoclonal antibody to somatomedin C.

1984 • 142 citations

Ligand activation of overexpressed epidermal growth factor receptors transforms NIH 3T3 mouse fibroblasts.

1988 • 139 citations

Variables controlling somatomedin production by cultured human fibroblasts

1983 • 129 citations

Gene transfer: DNA microinjection compared with DNA transfection with a very high efficiency.

1982 • 124 citations

Loss of epidermal growth factor requirement and malignant transformation

1979 • 117 citations

Growth-promoting effects of insulin-like growth factor-1 (IGF-1) on hematopoietic cells: overexpression of introduced IGF-1 receptor abrogates interleukin-3 dependency of murine factor-dependent cells by a ligand-dependent mechanism

1991 • 112 citations

EGF-R antisense RNA blocks expression of the epidermal growth factor receptor and suppresses the transforming phenotype of a human carcinoma cell line.

1992 • 102 citations

Somatomedin: Physiological Control and Effects on Cell Proliferation

1981 • 91 citations

Induction of two genes by glucose starvation in hamster fibroblasts.

1984 • 82 citations

Constitutively expressed c-myb abrogates the requirement for insulinlike growth factor 1 in 3T3 fibroblasts.

1991 • 80 citations

Characterization of Insulin, Insulin-Like Growth Factors I and II, and Growth Hormone Receptors on Human Leukemic Lymphoblasts*

1986 • 78 citations

Type I and II insulin-like growth factor receptors on human phytohemagglutinin-activated T lymphocytes

1987 • 68 citations

Insulin‐like growth factor‐I: Specific binding to high and low affinity sites and mitogenic action throughout the life span of WI‐38 cells

1987 • 67 citations

Cytokines and cell growth control.

1991 • 64 citations

The protooncogene c-myb increases the expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor messenger RNAs by a transcriptional mechanism.

1991 • 64 citations

Evidence for autocrine mitogenic stimulation by somatomedin-C/insulin-like growth factor I on an established human lung cancer cell line

1989 • 61 citations

The insulin-like growth factor 1 (IGF-1) receptor is responsible for mediating the effects of insulin, IGF-1, and IGF-2 in Xenopus laevis oocytes

1991 • 60 citations

Receptor binding and mitogenic effects of insulin and insulinlike growth factors I and II for human myeloid leukemic cells

1987 • 52 citations

An altered IGF-I receptor is present in human leukemic cells.

1990 • 43 citations

The role of the IGF1 receptor in the regulation of cdc2 mRNA levels in fibroblasts

1992 • 37 citations

Classification system based on the functional equivalency of mitogens that regulate WI-38 cell proliferation*1

1988 • 35 citations

Characterization of Insulin-Like Growth Factor I Receptors on Human Erythroleukemia Cell Line (K-562 Cells)

1987 • 28 citations

Characterization of rodent epidermal growth factor receptor transcripts using a mouse genomic probe

1986 • 27 citations

Abrogation of the requirements for added growth factors in 3T3 cells constitutively expressing the p53 and IGF-1 genes.

1988 • 20 citations

IGF-I Receptor and Gene Expression During the Cell Cycle

1993 • 4 citations