The Erk2 MAPK Regulates CD8 T Cell Proliferation and Survival

Mammalian MAP kinase signalling cascades

2001 • 5,041 citations

Interleukin-2: Inception, Impact, and Implications

1988 • 2,166 citations

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

MAP Kinases in the Immune Response

2002 • 1,620 citations

Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells

2001 • 1,277 citations

The extracellular signal-regulated kinase: Multiple substrates regulate diverse cellular functions

2006 • 1,247 citations

The Proapoptotic Activity of the Bcl-2 Family Member Bim Is Regulated by Interaction with the Dynein Motor Complex

1999 • 1,045 citations

The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition

2007 • 1,044 citations

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

2000 • 983 citations

Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

2001 • 861 citations

Massive Expansion of Antigen-Specific CD8+ T Cells during an Acute Virus Infection

1998 • 794 citations

Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells

2006 • 770 citations

ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

2008 • 653 citations

Defective Thymocyte Maturation in p44 MAP Kinase (Erk 1) Knockout Mice

1999 • 641 citations

The role of BH3-only proteins in the immune system

2005 • 608 citations

Heterogeneity and Cell-Fate Decisions in Effector and Memory CD8+ T Cell Differentiation during Viral Infection

2007 • 567 citations

Activated T Cell Death In Vivo Mediated by Proapoptotic Bcl-2 Family Member Bim

2002 • 564 citations

Extracellular signal-regulated kinases: ERKs in progress.

1991 • 519 citations

Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function

2003 • 466 citations

RasGRP is essential for mouse thymocyte differentiation and TCR signaling

2000 • 420 citations

Selective requirement for MAP kinase activation in thymocyte differentiation

1995 • 398 citations

COMPARTMENTALIZED RAS/MAPK SIGNALING

2006 • 396 citations

Control of T Cell Viability

2004 • 367 citations

The many paths to p38 mitogen-activated protein kinase activation in the immune system

2006 • 364 citations

An essential function of the mitogen‐activated protein kinase Erk2 in mouse trophoblast development

2003 • 361 citations

The Role of Erk1 and Erk2 in Multiple Stages of T Cell Development

2005 • 319 citations

Helix-loop-helix proteins and lymphocyte development

2005 • 312 citations

Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation

2003 • 309 citations

Regulatory phosphorylation of Bim: sorting out the ERK from the JNK

2005 • 303 citations

Inhibition of Mitogen-Activated Protein Kinase Kinase Blocks T Cell Proliferation But Does Not Induce or Prevent Anergy

1998 • 298 citations

Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity

2004 • 286 citations

Essential role for ERK2 mitogen‐activated protein kinase in placental development

2003 • 286 citations

Involvement of p21ras distinguishes positive and negative selection in thymocytes.

1995 • 278 citations

Cutting Edge: Antigen-Independent CD8 T Cell Proliferation

2001 • 277 citations

Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade

2001 • 276 citations

T cell clonal anergy

1997 • 257 citations

Regulation of gene transcription by mitogen-activated protein kinase signaling pathways

2006 • 245 citations

Transcriptional regulator Id2 mediates CD8+ T cell immunity

2006 • 242 citations

Positive and negative selection invoke distinct signaling pathways.

1996 • 234 citations

IL-2 Is Not Required for the Initiation of CD8 T Cell Cycling but Sustains Expansion

2003 • 232 citations

Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim

2003 • 229 citations

Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1

2006 • 224 citations

Differential Roles of ERK and p38 MAP Kinase Pathways in Positive and Negative Selection of T Lymphocytes

1998 • 217 citations

The Influence of the MAPK Pathway on T Cell Lineage Commitment

1997 • 217 citations

ERK1 and ERK2 mitogen-activated protein kinases affect Ras-dependent cell signaling differentially

2006 • 210 citations

Single and Combined Silencing of ERK1 and ERK2 Reveals Their Positive Contribution to Growth Signaling Depending on Their Expression Levels

2007 • 195 citations

T-lymphocyte death during shutdown of an immune response

2004 • 185 citations

Activation of ERK1/2 by ΔRaf-1 : ER* represses Bim expression independently of the JNK or PI3K pathways

2003 • 172 citations

RasGRP1 Transduces Low-Grade TCR Signals which Are Critical for T Cell Development, Homeostasis, and Differentiation

2002 • 153 citations

ERK1−/− Mice Exhibit Th1 Cell Polarization and Increased Susceptibility to Experimental Autoimmune Encephalomyelitis

2006 • 148 citations

The Ras/MAPK cascade and the control of positive selection

2003 • 142 citations

c-Jun NH2-Terminal Kinase (JNK)1 and JNK2 Have Distinct Roles in CD8+ T Cell Activation

2002 • 137 citations

Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells

2004 • 128 citations

Essential Role for IL-2 in the Regulation of Antiviral Extralymphoid CD8 T Cell Responses

2002 • 128 citations

Selective Expression of the Cre Recombinase in Late-Stage Thymocytes Using the Distal Promoter of the Lck Gene

2005 • 123 citations

Bim mediates apoptosis of CD127^lo effector T cells and limits T cell memory

2006 • 114 citations

Raf regulates positive selection

1996 • 90 citations

c-Jun NH2-Terminal Kinase (JNK)1 and JNK2 Signaling Pathways Have Divergent Roles in CD8+ T Cell–mediated Antiviral Immunity

2002 • 85 citations

A critical role for TNF receptor-associated factor 1 and Bim down-regulation in CD8 memory T cell survival

2006 • 84 citations

Regulation of expression of Bcl-2 protein family member Bim by T cell receptor triggering

2004 • 75 citations

ERK1-Deficient Mice Show Normal T Cell Effector Function and Are Highly Susceptible to Experimental Autoimmune Encephalomyelitis

2005 • 74 citations

Innate signals compensate for the absence of PKC-θ duringin vivoCD8+ T cell effector and memory responses

2005 • 70 citations

Protein Kinase C-θ Is an Early Survival Factor Required for Differentiation of Effector CD8+ T Cells

2005 • 62 citations

Frontline: An in-depth evaluation of the production of IL-2 by antigen-specific CD8 T cellsin vivo

2004 • 33 citations

A role for Ras signaling in coreceptor regulation during differentiation of a double-positive thymocyte cell line.

1997 • 13 citations