Role of thrombin receptor in breast cancer invasiveness

Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines

1992 • 530 citations

The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties.

1989 • 428 citations

Association of MMP-2 Activation Potential With Metastatic Progression in Human Breast Cancer Cell Lines Independent of MMP-2 Production

1993 • 216 citations

Thrombin Induces the Activation of Progelatinase A in Vascular Endothelial Cells

1995 • 177 citations

Signaling through G Proteins in Platelets: to the Integrins and Beyond

1997 • 172 citations

The Biochemistry of Cancer Dissemination

1997 • 170 citations

Pathways of Coagulation/Fibrinolysis Activation in Malignancy

1992 • 159 citations

Thrombin Promotes Activation of Matrix Metalloproteinase-2 Produced by Cultured Vascular Smooth Muscle Cells

1997 • 141 citations

Molecular and cellular analysis of basement membrane invasion by human breast cancer cells in Matrigel-basedin vitro assays

1993 • 122 citations

Thrombin Potently Stimulates Cytokine Production in Human Vascular Smooth Muscle Cells but Not in Mononuclear Phagocytes

1996 • 119 citations

Thrombin increases the metastatic potential of tumor cells

1993 • 111 citations

High levels of stromelysin-3 correlate with poor prognosis in patients with breast carcinoma

1996 • 107 citations

Vascular endothelial cell activation and permeability responses to thrombin

1995 • 98 citations

G12 Requirement for Thrombin-stimulated Gene Expression and DNA Synthesis in 1321N1 Astrocytoma Cells

1995 • 96 citations

Thrombin Receptor-Mediated Increase of Two Matrix Metalloproteinases, MMP-1 and MMP-3, in Human Endothelial Cells

1997 • 91 citations

Structural requirements and cell-type specificity for ligand activation of peroxisome proliferator-activated receptors

1997 • 90 citations

Cellular Localization of Enzymatically Active Thrombin in Intact Human Tissues by Hirudin Binding

1995 • 81 citations

Solid tumor cells express functional "tethered ligand" thrombin receptor.

1995 • 79 citations

Presence of the seven transmembrane thrombin receptor on human tumour cells: effect of activation on tumour adhesion to platelets and tumour tyrosine phosphorylation

1996 • 69 citations

Glycoprotein IIb/IIIa Blockade Inhibits Platelet-mediated Force Development and Reduces Gel Elastic Modulus

1995 • 67 citations

Altered cell-matrix contact: a prerequisite for breast cancer metastasis?

1997 • 60 citations

Collagen induced MMP-2 activation in human breast cancer

1994 • 60 citations

Expression and ligand binding of α2β1 integrin on breast carcinoma cells

1995 • 49 citations

Modulation of Vascular Endothelial Permeability by Thrombin

1992 • 40 citations

Expression and estrogen regulation of the HEM45 mRNA in human tumor lines and in the rat uterus

1998 • 39 citations

Progress in Hemostasis and Thrombosis

1979 • 35 citations

Issues in the Development of Thrombin Receptor Antagonists

1995 • 30 citations

Post-receptor events associated with thrombin-induced platelet activation

1993 • 21 citations

Post-receptor events associated with thrombin-induced platelet activation

1993 • 20 citations

Both estradiol and tamoxifen decrease proliferation and invasiveness of cancer cells transfected with a mutated estrogen receptor

1997 • 16 citations

Blood Coagulation Activation in Cancer: Challenges for Cancer Treatment

1995 • 14 citations

Rat uterine stromal cells: thrombin receptor and growth stimulation by thrombin.

1996 • 12 citations

Thrombin interactions with cells of the megakaryocytic lineage

1993 • 7 citations

Thrombin interactions with cells of the megakaryocytic lineage

1993 • 7 citations

Prothrombin.

1978 • 2 citations

Blood Coagulation Factors in Tumor Tissue: Implications for Cancer Therapy

1996 • 1 citations

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