Thrombin immobilized to extracellular matrix is a potent mitogen for vascular smooth muscle cells: nonenzymatic mode of action.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

The Pathogenesis of Atherosclerosis — An Update

1986 • 4,951 citations

RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination

1977 • 3,548 citations

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

The biology of platelet-derived growth factor

1986 • 2,036 citations

Induction of c-fos gene and protein by growth factors precedes activation of c-myc

1984 • 1,463 citations

Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix.

1987 • 1,045 citations

Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein

1984 • 949 citations

A significant part of macrophage-derived growth factor consists of at least two forms of PDGF

1985 • 719 citations

Evolution of Proteolytic Enzymes

1984 • 641 citations

Human thrombins. Production, evaluation, and properties of alpha-thrombin.

1977 • 587 citations

Interleukin 1: a mitogen for human vascular smooth muscle cells that induces the release of growth-inhibitory prostanoids.

1988 • 519 citations

Cultured endothelial cells produce a platelet-derived growth factor-like protein

1983 • 507 citations

Mitogenic activity of blood components. I. Thrombin and prothrombin.

1975 • 481 citations

Heparin cofactor II. Purification and properties of a heparin-dependent inhibitor of thrombin in human plasma.

1982 • 427 citations

HHF35, a muscle-actin-specific monoclonal antibody. I. Immunocytochemical and biochemical characterization.

1987 • 427 citations

Activated human monocytes express the c-sis proto-oncogene and release a mediator showing PDGF-like activity

1986 • 380 citations

Immunoreactive fibroblast growth factor in cells of peritoneal exudate suggests its identity with macrophage-derived growth factor

1985 • 372 citations

Monocyte Chemotaxis: Stimulation by Specific Exosite Region in Thrombin

1983 • 333 citations

Inhibition of vascular smooth muscle cell growth by endothelial cell-derived heparin. Possible role of a platelet endoglycosidase.

1982 • 312 citations

Thrombin‐induced increase in albumin permeability across the endothelium

1986 • 307 citations

The structure of the human tissue-type plasminogen activator gene: correlation of intron and exon structures to functional and structural domains.

1984 • 303 citations

Biological and biochemical properties of fibroblast growth factors. Implications for the pathogenesis of atherosclerosis.

1989 • 228 citations

Binding of thrombin to subendothelial extracellular matrix. Protection and expression of functional properties.

1989 • 212 citations

An endothelial cell-dependent pathway of coagulation.

1985 • 212 citations

Basic fibroblast growth factor is an extracellular matrix component required for supporting the proliferation of vascular endothelial cells and the differentiation of PC12 cells.

1989 • 190 citations

Thrombin active site regions required for fibroblast receptor binding and initiation of cell division.

1980 • 186 citations

Binding of plasminogen to extracellular matrix.

1986 • 175 citations

Thrombin-induced gap formation in confluent endothelial cell monolayers in vitro

1983 • 164 citations

Intron–exon splice junctions map at protein surfaces

1982 • 148 citations

Growth factors adherent to cell substrate are mitogenically active in situ

1982 • 141 citations

Identification of a thrombin sequence with growth factor activity on macrophages.

1986 • 132 citations

Regulation of oncogene expression in cultured aortic smooth muscle cells. Post-transcriptional control of c-myc mRNA.

1986 • 131 citations

Biologic actions of heparin.

1977 • 125 citations

Selective immobilization of alpha-thrombin by surface-bound fibrin.

1981 • 123 citations

Cell surface action of thrombin is sufficient to initiate division of chick cells

1978 • 112 citations

Characterization of bovine prothrombin mRNA and its translation product

1984 • 94 citations

Comparison of the ability of basement membranes produced by corneal endothelial and mouse-derived Endodermal PF-HR-9 cells to support the proliferation and differentiation of bovine kidney tubule epithelial cells in vitro.

1984 • 90 citations

Studies on the mechanism of thrombin. Interaction with fibrin.

1983 • 84 citations

Morphological and biochemical observations on cells derived from the in vitro differentiation of the embryonal carcinoma cell line PCC4-F.

1977 • 81 citations

Protease mitogenic response of chick embryo fibroblasts and receptor binding/processing of human alpha-thrombin.

1981 • 69 citations

Dual Effect of Normal and Stimulated Macrophages and Their Conditioned Media on Target Cell Proliferation

1979 • 68 citations

Inhibition of trypsin-like serine proteinases by tripeptide arginyl and lysyl chloromethylketones

1984 • 66 citations

Selective Degradation of Basement Membrane Macromolecules by Metastatic Melanoma Cells<xref ref-type="fn" rid="FN2">2</xref>

1984 • 63 citations

Growth‐promoting effects of esterolytically inactive thrombin on macrophages

1986 • 37 citations

Biologic Activities of Nonenzymatic Thrombin: Elucidation of a Macrophage Interactive Domain

1986 • 20 citations

Thrombin-induced gap formation in confluent endothelial cell monolayers in vitro

1983 • 19 citations

Mediation of cellular events by thrombin.

1986 • 19 citations