Transcriptional networks in developing and mature B cells

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

1998 • 5,178 citations

Signaling to NF-κB

2004 • 3,768 citations

Missing Pieces in the NF-κB Puzzle

2002 • 3,560 citations

IRF Family of Transcription Factors as Regulators of Host Defense

2001 • 1,566 citations

Requirement of Transcription Factor PU.1 in the Development of Multiple Hematopoietic Lineages

1994 • 1,506 citations

Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1

1999 • 1,392 citations

B Cell Development Pathways

2001 • 1,185 citations

Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses

1995 • 1,184 citations

Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

1999 • 1,139 citations

Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities.

1996 • 1,115 citations

Requirement for NF-κB in osteoclast and B-cell development

1997 • 994 citations

The ikaros gene is required for the development of all lymphoid lineages

1994 • 976 citations

Stepwise Reprogramming of B Cells into Macrophages

2004 • 919 citations

B Cell Development in the Spleen Takes Place in Discrete Steps and Is Determined by the Quality of B Cell Receptor–Derived Signals

1999 • 843 citations

Regulation of plasma-cell development

2005 • 826 citations

Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP

1994 • 807 citations

E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

1994 • 766 citations

The Rel/NF-κB Family Directly Activates Expression of the Apoptosis Inhibitor Bcl-x_L

2000 • 747 citations

Regulation of B Lymphocyte and Macrophage Development by Graded Expression of PU.1

2000 • 712 citations

Subnuclear Compartmentalization of Immunoglobulin Loci During Lymphocyte Development

2002 • 708 citations

The helix-loop-helix gene E2A is required for B cell formation

1994 • 679 citations

Failure of B-cell differentiation in mice lacking the transcription factor EBF

1995 • 667 citations

Immunodeficiency and Chronic Myelogenous Leukemia-like Syndrome in Mice with a Targeted Mutation of the ICSBP Gene

1996 • 650 citations

Selective Defects in the Development of the Fetal and Adult Lymphoid System in Mice with an Ikaros Null Mutation

1996 • 619 citations

Ikaros DNA-Binding Proteins Direct Formation of Chromatin Remodeling Complexes in Lymphocytes

1999 • 583 citations

Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function

1997 • 581 citations

Thymopoiesis independent of common lymphoid progenitors

2003 • 548 citations

Notch regulation of lymphocyte development and function

2004 • 548 citations

Notch2 Is Preferentially Expressed in Mature B Cells and Indispensable for Marginal Zone B Lineage Development

2003 • 541 citations

Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1

2004 • 497 citations

Notch–RBP-J signaling is involved in cell fate determination of marginal zone B cells

2002 • 476 citations

Defects in cardiac outflow tract formation and pro-B-lymphocyte expansion in mice lacking Sox-4

1996 • 464 citations

Transcription from the RAG1 Locus Marks the Earliest Lymphocyte Progenitors in Bone Marrow

2002 • 460 citations

Wnt Signaling Regulates B Lymphocyte Proliferation through a LEF-1 Dependent Mechanism

2000 • 444 citations

E2A Deficiency Leads to Abnormalities in αβ T-Cell Development and to Rapid Development of T-Cell Lymphomas

1997 • 400 citations

Pax5 inducesV-to-DJrearrangements and locus contraction of theimmunoglobulin heavy-chaingene

2004 • 392 citations

Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors

1999 • 386 citations

The Transcription Factor c-Maf Controls the Production of Interleukin-4 but Not Other Th2 Cytokines

1999 • 377 citations

Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation

1997 • 360 citations

B-Lymphocyte Development Is Regulated by the Combined Dosage of Three Basic Helix-Loop-Helix Genes, E2A, E2-2, and HEB†

1996 • 339 citations

The Follicular versus Marginal Zone B Lymphocyte Cell Fate Decision Is Regulated by Aiolos, Btk, and CD21

2001 • 335 citations

Coordinate Regulation of B Cell Differentiation by the Transcription Factors EBF and E2A

1999 • 334 citations

PU.1 Regulates Expression of the Interleukin-7 Receptor in Lymphoid Progenitors

2002 • 316 citations

WNT signalling and haematopoiesis: a WNT–WNT situation

2005 • 315 citations

Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments

1998 • 314 citations

Aiolos Regulates B Cell Activation and Maturation to Effector State

1998 • 313 citations

Cutting Edge: BLyS Enables Survival of Transitional and Mature B Cells Through Distinct Mediators

2002 • 309 citations

Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes

1999 • 308 citations

PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors

1998 • 296 citations

Reversion of B Cell Commitment upon Loss of Pax5 Expression

2002 • 285 citations

B-cell-specif ic coactivator OBF-1/OCA-B/Bob1 required for immune response and germinal centre formation

1996 • 284 citations

EBF and E47 Collaborate to Induce Expression of the Endogenous Immunoglobulin Surrogate Light Chain Genes

1997 • 282 citations

PU.1 Functions in a Cell-Autonomous Manner to Control the Differentiation of Multipotential Lymphoid–Myeloid Progenitors

1997 • 276 citations

Regulation of Marginal Zone B Cell Development by MINT, a Suppressor of Notch/RBP-J Signaling Pathway

2003 • 269 citations

Constitutive expression of the Id1 gene impairs mouse B cell development

1994 • 266 citations

Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival.

1993 • 265 citations

THE ROLE OF THE IKAROS GENE IN LYMPHOCYTE DEVELOPMENT AND HOMEOSTASIS

1997 • 262 citations

IRF-4,8 orchestrate the pre-B-to-B transition in lymphocyte development

2003 • 262 citations

Revising B Cell Receptors

2000 • 261 citations

Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family

2000 • 247 citations

Pax5/BSAP Maintains the Identity of B Cells in Late B Lymphopoiesis

2001 • 246 citations

The B-cell-specific transcription coactivator OCA-B/OBF-1/Bob-1 is essential for normal production of immunoglobulin isotypes

1996 • 240 citations

Pax5 Promotes B Lymphopoiesis and Blocks T Cell Development by Repressing Notch1

2002 • 239 citations

Assembling a Gene Regulatory Network for Specification of the B Cell Fate

2004 • 233 citations

Defects in Hemopoietic Stem Cell Activity in Ikaros Mutant Mice

1999 • 230 citations

Identification of very early lymphoid precursors in bone marrow and their regulation by estrogen

2001 • 230 citations

Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors

1998 • 228 citations

E2A and EBF Act in Synergy with the V(D)J Recombinase to Generate a Diverse Immunoglobulin Repertoire in Nonlymphoid Cells

2000 • 227 citations

The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression

2000 • 226 citations

Essential Role of RelB in Germinal Center and Marginal Zone Formation and Proper Expression of Homing Chemokines

2001 • 221 citations

Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential

2003 • 205 citations

Circulating hematopoietic progenitors with T lineage potential

2004 • 205 citations

Bipotential B-macrophage progenitors are present in adult bone marrow

2001 • 185 citations

Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription

2004 • 178 citations

Surrogate Light Chain Expression Is Required to Establish Immunoglobulin Heavy Chain Allelic Exclusion during Early B Cell Development

1996 • 174 citations

Defective B cell receptor-mediated responses in mice lacking the Ets protein, Spi-B

1997 • 172 citations

Early B Cell Factor Promotes B Lymphopoiesis with Reduced Interleukin 7 Responsiveness in the Absence of E2A

2004 • 169 citations

Nuclear Factor κb Is Required for the Development of Marginal Zone B Lymphocytes

2000 • 160 citations

Ikaros is critical for B cell differentiation and function

2002 • 160 citations

Widespread Failure of Hematolymphoid Differentiation Caused by a Recessive Niche-Filling Allele of the Ikaros Transcription Factor

2003 • 152 citations

Down-regulation of TDT transcription in CD4⁺CD8⁺thymocytes by Ikaros proteins in direct competition with an Ets activator

2001 • 151 citations

The CD8α Gene Locus Is Regulated by the Ikaros Family of Proteins

2002 • 149 citations

A Conserved Motif Present in a Class of Helix-Loop-Helix Proteins Activates Transcription by Direct Recruitment of the SAGA Complex

1999 • 149 citations

Binding of Ikaros to the lambda5 promoter silences transcription through a mechanism that does not require heterochromatin formation

2001 • 148 citations

B lymphocytes are impaired in mice lacking the transcriptional co‐activator Bob1/OCA‐B/OBF1

1996 • 139 citations

Essential role of Id2 in negative regulation of IgE class switching

2002 • 138 citations

EBF contains a novel zinc coordination motif and multiple dimerization and transcriptional activation domains.

1995 • 138 citations

VpreB1/VpreB2/λ5 Triple-Deficient Mice Show Impaired B Cell Development but Functional Allelic Exclusion of the IgH Locus

2002 • 136 citations

E2A proteins: essential regulators at multiple stages of B‐cell development

2000 • 116 citations

Functional Replacement of the Mouse E2A Gene with a Human HEB cDNA

1998 • 112 citations

PU.1 and Spi-B Are Required for Normal B Cell Receptor–Mediated Signal Transduction

1999 • 111 citations

Early B-Cell Factor, E2A, and Pax-5 Cooperate To Activate the Early B Cell-Specific mb-1 Promoter

2002 • 110 citations

B cell development and immunoglobulin gene transcription in the absence of Oct-2 and OBF-1

2001 • 108 citations

Analysis of Notch1 Function by In Vitro T Cell Differentiation ofPax5Mutant Lymphoid Progenitors

2004 • 102 citations

Oct-2 is required early in T cell-independent B cell activation for G1 progression and for proliferation

1994 • 101 citations

Cloning and Characterization of a Promoter Flanking the Early B Cell Factor (EBF) Gene Indicates Roles for E-Proteins and Autoregulation in the Control of EBF Expression

2002 • 94 citations

A Wnt-Wnt Situation

2003 • 93 citations

Multiple hematopoietic cell lineages develop in vivo from transplanted Pax5-deficient pre-B I–cell clones

2002 • 93 citations

A stepwise epigenetic process controls immunoglobulin allelic exclusion

2004 • 84 citations

Lymphoid-specific transcription mediated by the conserved octamer site: Who is doing what?

1998 • 74 citations

OcaB Is Required for Normal Transcription and V(D)J Recombination of a Subset of Immunoglobulin κ Genes

2002 • 73 citations

Regulation of BOB.1/OBF.1 stability by SIAH

2001 • 73 citations

The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1

2001 • 72 citations

The B Lymphocyte-Specific Coactivator BOB.1/OBF.1 Is Required at Multiple Stages of B-Cell Development

2001 • 68 citations

Corecruitment of the Grg4 repressor by PU.1 is critical for Pax5‐mediated repression of B‐cell‐specific genes

2004 • 65 citations

Lack of the Transcriptional Coactivator OBF-1 Prevents the Development of Systemic Lupus Erythematosus-Like Phenotypes in Aiolos Mutant Mice

2003 • 65 citations

Regulation of E2A gene expression in B-lymphocyte development

2004 • 52 citations

PU.1/Spi-B Regulation of c-rel Is Essential for Mature B Cell Survival

2001 • 52 citations

HMG box containing transcription factors in lymphocyte differentiation

1998 • 51 citations

oct-2 gene disruption eliminates the peritoneal B-1 lymphocyte lineage and attenuates B-2 cell maturation and function.

1997 • 51 citations

BOB.1/OBF.1 Deficiency Affects Marginal-Zone B-Cell Compartment

2002 • 50 citations

Analysis of Gene Expression and Ig Transcription in PU.1/Spi-B-Deficient Progenitor B Cell Lines

2004 • 49 citations

Spi-B can functionally replace PU.1 in myeloid but not lymphoid development

2002 • 47 citations

Cutting Edge: Lack of Peripheral B Cells and Severe Agammaglobulinemia in Mice Simultaneously Lacking Bruton’s Tyrosine Kinase and the B Cell-Specific Transcriptional Coactivator OBF-1

2000 • 35 citations

B cell development and immunoglobulin transcription in Oct-1-deficient mice

2004 • 35 citations

Identification and Characterization of a Novel OCA-B Isoform

2001 • 34 citations

A right royal rumpus

1998 • 13 citations