Angiogenesis: a Dynamic Balance of Stimulators and Inhibitors

Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth

1997 • 4,504 citations

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1996 • 4,143 citations

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1996 • 3,664 citations

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

1994 • 3,367 citations

Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.

1995 • 3,139 citations

Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis

1996 • 2,844 citations

Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells

1989 • 2,267 citations

Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning

1996 • 1,969 citations

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

1995 • 1,808 citations

A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases.

1996 • 1,670 citations

Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth

1990 • 1,308 citations

The implications of angiogenesis for the biology and therapy of cancer metastasis

1994 • 1,120 citations

The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF.

1993 • 1,114 citations

A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.

1990 • 1,062 citations

Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor.

1991 • 999 citations

Vascular permeability factor (VPF, VEGF) in tumor biology

1993 • 839 citations

Capillary endothelial cells express basic fibroblast growth factor, a mitogen that promotes their own growth

1987 • 764 citations

A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines.

1986 • 641 citations

Protamine is an inhibitor of angiogenesis

1982 • 582 citations

Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity

1993 • 574 citations

Endothelial receptor tyrosine kinases involved in angiogenesis.

1995 • 537 citations

Isolation of the thrombospondin membrane receptor.

1987 • 518 citations

The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells.

1995 • 517 citations

Cell attachment to thrombospondin: the role of ARG-GLY-ASP, calcium, and integrin receptors.

1988 • 481 citations

Regulation of the activity of a new inhibitor of angiogenesis by a cancer suppressor gene

1989 • 475 citations

Vascular permeability factor/vascular endothelial growth factor:A multifunctional angiogenic cytokine

1997 • 474 citations

Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system.

1993 • 470 citations

Transforming growth factor beta 1-induced changes in cell migration, proliferation, and angiogenesis in the chicken chorioallantoic membrane.

1990 • 470 citations

Fibrin containing gels induce angiogenesis. Implications for tumor stroma generation and wound healing.

1987 • 450 citations

tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors.

1992 • 410 citations

Persico MG.Isolation of a human placenta cDNA coding for a potein related to the vascular premeability factor

1991 • 352 citations

Thrombospondins: structure and regulation of expression

1992 • 345 citations

COMP (cartilage oligomeric matrix protein) is structurally related to the thrombospondins.

1992 • 327 citations

Isolations of a Cartilage Factor That Inhibits Tumor Neovascularization

1976 • 308 citations

Vesiculo-vacuolar organelles and the regulation of venule permeability to macromolecules by vascular permeability factor, histamine, and serotonin.

1996 • 280 citations

Thrombospondin modulates focal adhesions in endothelial cells.

1989 • 271 citations

Control of smooth muscle cell growth by components of the extracellular matrix: autocrine role for thrombospondin.

1986 • 259 citations

Molecular Cloning and Characterization of Mouse TIE and TEK Receptor Tyrosine Kinase Genes and Their Expression in Hematopoietic Stem Cells

1993 • 224 citations

Fibroblast growth factors: broad spectrum mitogens with potent angiogenic activity

1986 • 199 citations

Fibrin Gel Investment Associated With Line 1 and Line 10 Solid Tumor Growth, Angiogenesis, and Fibroplasia in Guinea Pigs. Role of Cellular Immunity, Myofibroblasts, Microvascular Damage, and Infarction in Line 1 Tumor Regression<xref ref-type="fn" rid="FN2">2</xref>

1979 • 198 citations

Physiology of Thrombospondin

1990 • 195 citations

Pathways of macromolecular tracer transport across venules and small veins. Structural basis for the hyperpermeability of tumor blood vessels.

1992 • 191 citations

Specific inhibition of endothelial cell proliferation by thrombospondin

1990 • 168 citations

Heparin- and sulfatide-binding peptides from the type I repeats of human thrombospondin promote melanoma cell adhesion.

1992 • 163 citations

Control of tumor growth in animals by infusion of an angiogenesis inhibitor.

1980 • 154 citations

Thrombospondin-1, an inhibitor of angiogenesis, is regulated by progesterone in the human endometrium.

1996 • 144 citations

Identification and characterization of thrombospondin-4, a new member of the thrombospondin gene family.

1993 • 143 citations

A second, expressed thrombospondin gene (Thbs2) exists in the mouse genome

1991 • 120 citations

Thrombospondin 3 (Thbs3), a new member of the thrombospondin gene family.

1992 • 115 citations

CD36 peptides enhance or inhibit CD36-thrombospondin binding. A two-step process of ligand-receptor interaction.

1992 • 100 citations

Expression of thrombospondins by endothelial cells. Injury is correlated with TSP-1.

1995 • 80 citations

The interaction of thrombospondin with platelet glycoprotein GPIIb-IIIa

1989 • 64 citations

Tumor angiogenesis inhibition by prostaglandin synthetase inhibitors.

1986 • 53 citations

Thrombospondin II: Partial cDNA sequence, chromosome location, and expression of a second member of the thrombospondin gene family in humans

1992 • 49 citations

Thrombospondin gene expression by endothelial cells in culture is modulated by cell proliferation, cell shape and the substratum

1990 • 44 citations

Human carcinoma cells bind thrombospondin through a Mr 80,000/105,000 receptor.

1991 • 35 citations

Isolation and Characterization of the Mouse Thrombospondin 3 (Thbs3) Gene

1993 • 34 citations

A factor in conditioned medium of rabbit costal chondrocytes inhibits the proliferation of cultured endothelial cells and angiogenesis induced by B16 melanoma: its relation with cartilage-derived anti-tumor factor (CATF).

1987 • 11 citations