Signaling by HGF and KGF in corneal epithelial cells: Ras/MAP kinase and Jak-STAT pathways.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

1991 • 2,230 citations

Stat3: a STAT Family Member Activated by Tyrosine Phosphorylation in Response to Epidermal Growth Factor and Interleukin-6

1994 • 2,037 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth.

1992 • 1,345 citations

Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor

1991 • 1,176 citations

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1993 • 1,077 citations

Human KGF is FGF-Related with Properties of a Paracrine Effector of Epithelial Cell Growth

1989 • 989 citations

A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

1994 • 983 citations

Purification and characterization of a newly identified growth factor specific for epithelial cells.

1989 • 842 citations

Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene.

1992 • 760 citations

An SV40-immortalized human corneal epithelial cell line and its characterization.

1995 • 714 citations

Scatter factor induces blood vessel formation in vivo.

1993 • 704 citations

Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET.

1991 • 698 citations

Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells.

1990 • 695 citations

Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha.

1992 • 661 citations

Large induction of keratinocyte growth factor expression in the dermis during wound healing.

1992 • 603 citations

The Function of KGF in Morphogenesis of Epithelium and Reepithelialization of Wounds

1994 • 597 citations

The pathway to signal achievement

1993 • 563 citations

Regulation of Scatter Factor/Hepatocyte Growth Factor Responses by Ras, Rac, and Rho in MDCK Cells

1995 • 547 citations

Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity.

1988 • 458 citations

Growth factor signaling: Where is the specificity?

1992 • 341 citations

Three patterns of cytokine expression potentially involved in epithelial‐fibroblast interactions of human ocular surface

1995 • 338 citations

Hepatocyte growth factor: molecular structure, roles in liver regeneration, and other biological functions.

1992 • 327 citations

Keratinocyte growth factor

1995 • 321 citations

Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor.

1992 • 316 citations

Enhanced Tumorigenicity and Invasion-Metastasis by Hepatocyte Growth Factor/Scatter Factor-Met Signalling in Human Cells Concomitant with Induction of the Urokinase Proteolysis Network

1996 • 312 citations

Mechanical loading activates mitogen-activated protein kinase and S6 peptide kinase in cultured rat cardiac myocytes

1993 • 290 citations

Hepatocyte growth factor/scatter factor and its receptor, the c-met proto-oncogene product

1993 • 281 citations

Keratinocyte growth factor induces proliferation of hepatocytes and epithelial cells throughout the rat gastrointestinal tract.

1994 • 276 citations

Cell-free activation of a DNA-binding protein by epidermal growth factor

1993 • 263 citations

The tyrosine-phosphorylated hepatocyte growth factor/scatter factor receptor associates with phosphatidylinositol 3-kinase.

1991 • 259 citations

Effect of Epidermal Growth Factor, Hepatocyte Growth Factor, and Keratinocyte Growth Factor, on Proliferation, Motility and Differentiation of Human Corneal Epithelial Cells

1994 • 247 citations

The met Proto-Oncogene Receptor and Lumen Formation

1992 • 246 citations

Roles of JAKs in Activation of STATs and Stimulation of c-fos Gene Expression by Epidermal Growth Factor

1996 • 221 citations

Growth factors in skin wound healing.

1995 • 210 citations

Hepatocyte growth factor/scatter factor stimulates the Ras-guanine nucleotide exchanger

1993 • 206 citations

Human keratinocyte growth factor effects in a porcine model of epidermal wound healing.

1993 • 200 citations

Regulation of cell movement: the motogenic cytokines

1991 • 199 citations

The motility signal of scatter factor/hepatocyte growth factor mediated through the receptor tyrosine kinase met requires intracellular action of Ras.

1994 • 175 citations

Modulation of keratinocyte growth factor and its receptor in reepithelializing human skin.

1995 • 165 citations

PKC epsilon functions as an oncogene by enhancing activation of the Raf kinase.

1996 • 153 citations

Expression of Local Hepatocyte Growth Factor System in Vascular Tissues

1995 • 135 citations

STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family.

1996 • 133 citations

Roles of HGF as a pleiotropic factor in organ regeneration.

1993 • 131 citations

Hepatocyte growth factor and hepatocyte growth factor receptor in the lacrimal gland, tears, and cornea.

1996 • 125 citations

Peptide growth factors in the prostate as mediators of stromal epithelial interaction

1996 • 116 citations

Tpr, a large coiled coil protein whose amino terminus is involved in activation of oncogenic kinases, is localized to the cytoplasmic surface of the nuclear pore complex.

1994 • 114 citations

Epidermal growth factor (EGF) Increases the in vitro invasion, motility and adhesion interactions of the primary renal carcinoma cell line, A704

1996 • 110 citations

Motogenic and morphogenic activity of epithelial receptor tyrosine kinases.

1996 • 100 citations

Molecular Cell Biology for the Refractive Corneal Surgeon: Programmed Cell Death and Wound Healing

1997 • 100 citations

Insulin-like growth factor mediated stromal-epithelial interactions in human breast cancer

1994 • 98 citations

Keratinocyte growth factor induces pancreatic ductal epithelial proliferation.

1994 • 88 citations

Human recombinant epidermal growth factor in experimental corneal wound healing.

1991 • 86 citations

Role of epidermal growth factor (EGF) and its receptor in the development of the human placenta

1995 • 81 citations

Mitogen-activated protein kinase activation in hepatocyte growth factor-stimulated rat hepatocytes: Involvement of protein tyrosine kinase and protein kinase C

1996 • 80 citations

Keratinocyte growth factor accelerates corneal epithelial wound healing in vivo.

1995 • 80 citations

Systematic Mapping of Potential Binding Sites for Shc and Grb2 SH2 Domains on Insulin Receptor Substrate-1 and the Receptors for Insulin, Epidermal Growth Factor, Platelet-derived Growth Factor, and Fibroblast Growth Factor

1996 • 66 citations

A keratinocyte growth factor receptor-derived peptide antagonist identifies part of the ligand binding site

1993 • 61 citations

Expression and characterization of human lactoferrin in yeast Saccharomyces cerevisiae

1993 • 56 citations

Hepatocyte growth factor/scatter factor (HGF/SF) signals via the STAT3/APRF transcription factor in human hepatoma cells and hepatocytes

1997 • 48 citations

A protein tyrosine phosphatase activity associated with the hepatocyte growth factor/scatter factor receptor.

1993 • 44 citations

Inhibitory actions of cyclic adenosine monophosphate and pertussis toxin define two distinct epidermal growth factor-regulated pathways leading to activation of mitogen-activated protein kinase in rat hepatocytes

1996 • 44 citations

Parietal cell MAP kinases: multiple activation pathways

1996 • 41 citations

Epithelial-Mesenchymal Interactions in Cancer

1995 • 40 citations

Hepatocyte growth factor (HGF), keratinocyte growth factor (KGF), and their receptors in human breast cells and tissues: alternative receptors.

1994 • 40 citations

Cellular mechanisms, interactions, and dynamics of gastric ulcer healing.

1995 • 33 citations

met and HGF-SF in normal melanocytes and melanoma cells.

1993 • 29 citations

Breast carcinoma: a collective disorder

1994 • 27 citations

Stage-Specific Elevated Expression of the Genes for Hepatocyte Growth Factor, Keratinocyte Growth Factor, and Their Receptors during the Morphogenesis and Differentiation of Rat Stomach Mucosa

1996 • 22 citations

Dissociation of C‐fos Induction and Mitogen‐Activated‐Protein Kinase Activation from the Hepatocyte‐Growth‐Factor‐Induced Motility Response in Human Gastric Carcinoma Cells

1996 • 17 citations

Common and Distinct Elements in Insulin and PDGF Signaling^a

1995 • 14 citations

Protein kinase C-independent activation of mitogen-activated protein kinase by epidermal growth factor in skin fibroblasts

1996 • 12 citations

Hepatocyte growth factor-induced signal transduction in two normal mouse epithelial cell lines.

1995 • 11 citations

Regulation of scatter factor (hepatocyte growth factor) production by tumor-stroma interaction

1995 • 11 citations

In vitro regulation of HGF-SF expression by epithelial-mesenchymal interactions.

1993 • 4 citations