Neurotransmitter and neuromodulator function in the kindled seizure and state

Modification of seizure activity by electrical stimulation: II. Motor seizure

1972 • 6,939 citations

A permanent change in brain function resulting from daily electrical stimulation

1969 • 3,056 citations

Specific benzodiazepine receptors in rat brain characterized by high-affinity (3H)diazepam binding.

1977 • 1,246 citations

Modification of seizure activity by electrical stimulation: I. after-discharge threshold

1972 • 735 citations

New concepts on the mechanism of action of benzodiazepines

1975 • 539 citations

Kindling

1978 • 482 citations

High densities of benzodiazepine receptors in human cortical areas

1977 • 406 citations

Radiohistochemical localization of benzodiazepine receptors in rat brain.

1980 • 382 citations

Morphine and Enkephalin: Analgesic and Epileptic Properties

1977 • 358 citations

Sodium Valproate

1977 • 318 citations

The kindling model of epilepsy: A review

1980 • 287 citations

Development of a New Pharmacological Seizure Model: Effects of Anticonvulsants on Cortical‐and Amygdala‐Kindled Seizures in the Rat

1980 • 261 citations

Effects of atropine, reserpine, 6-hydroxydopamine, and handling on seizure development in the rat

1973 • 240 citations

A permanent change in convulsive threshold in normal and Brain‐Damaged Rats with repeated small doses of Pentylenetetrazol*

1972 • 229 citations

THE EFFECT OF REPEATED DOSES OF COCAINE IN THE RAT

1932 • 217 citations

Kindling of the mesolimbic dopamine system

1978 • 210 citations

Epileptic properties of leucine- and methionine-enkephalin: Comparison with morphine and reversibility by naloxone

1978 • 208 citations

Rapid Changes in Brain Benzodiazepine Receptors After Experimental Seizures

1978 • 196 citations

Behavioral Toxicology

1975 • 190 citations

Role of forebrain catecholamines in amygdaloid kindling

1980 • 187 citations

Repeated electroconvulsive shocks and the brain content of endorphins

1979 • 179 citations

Potentiation of amygdaloid kindling and Metrazol-induced seizures by 6-hydroxydopamine in rats

1974 • 173 citations

Valproic Acid

1980 • 160 citations

Different Brain Areas Mediate the Analgesic and Epileptic Properties of Enkephalin

1978 • 158 citations

Postseizure inhibition of kindled seizures

1977 • 157 citations

Endogenous opiods may mediate post-ictal behavioral depression in amygdaloid-kindled rats

1979 • 156 citations

Classification of Opioids on the Basis of Change in Seizure Threshold in Rats

1979 • 152 citations

Repeated seizures induce long-term increase in hippocampal benzodiazepine receptors.

1980 • 150 citations

Physiology and pharmacology of epileptogenic phenomena

1983 • 150 citations

Enkephalin-containing pathway: amygdaloid efferents in the stria terminalis

1978 • 146 citations

Cholinergic seizure kindling in the rat: Comparison of caudate, amygdala and hippocampus

1975 • 145 citations

Anticonvulsant drugs and their antagonism of kindled amygdaloid seizures in rats

1980 • 138 citations

Pharmacological Prophylaxis in the Kindling Model of Epilepsy

1977 • 133 citations

Interictal EEG spikes correlate with decreased, rather than increased, epileptogenicity in amygdaloid kindled rats

1980 • 130 citations

Potentiation of amygdala kindling in adult or infant rats by injections of 6-hydroxydopamine

1979 • 127 citations

The pharmacology of seizures induced by sensitization with low intensity brain stimulation

1973 • 124 citations

Behavioral analysis of the effects of 15 anticonvulsants in the amygdaloid kindled rat

1979 • 122 citations

Administration of an organophosphate causes a decrease in muscarinic receptor levels in rat brain

1979 • 122 citations

The effect of interstimulation interval on the assessment and stability of kindled seizure thresholds

1981 • 121 citations

Evolution of repeated hippocampal seizures in the cat

1961 • 119 citations

Long-lasting depletion of dopamine in the rat amygdala induced by kindling stimulation

1977 • 116 citations

Involvement of catecholamines in kindled amygdaloid convulsions in the rat

1979 • 112 citations

Circadian rhythm in rat brain opiate receptor

1981 • 112 citations

Behavioral Toxicity of Anticholinesterase Agents: Methodological, Neurochemical, and Neuropsychological Aspects

1975 • 112 citations

Amygdaloid kindling enhances the enkephalin content in the rat brain

1981 • 108 citations

Benzodiazepine receptors in the brain as affected by different experimental stresses: The changes are small and not undirectional

1979 • 99 citations

Temporal Lobe Aggression in Rats

1977 • 99 citations

Neurochemical mapping of GABAergic systems in the amygdaloid complex and bed nucleus of the stria terminalis

1978 • 98 citations

Post-activation potentiation and the kindling phenomenon

1975 • 92 citations

Seizures down-regulate muscarinic cholinergic receptors in hippocampal formation

1982 • 92 citations

ALTERATIONS IN GABA METABOLISM AND MET‐ENKEPHALIN CONTENT IN RAT BRAIN FOLLOWING REPEATED ELECTROCONVULSIVE SHOCKS

1978 • 88 citations

The benzodiazepine receptor: its development and its modulation by gamma-aminobutyric acid.

1980 • 87 citations

Kindling of neuroanatomic pathways during recurrent focal penicillin seizures

1978 • 84 citations

Selective alterations of regional β-adrenergic receptor binding in the kindling model of epilepsy

1978 • 82 citations

Neuronal Supersensitivity to Acetylcholine Induced by Kindling in the Rat Hippocampus

1979 • 82 citations

Experimental seizure-threshold testing with fluorthyl.

1969 • 81 citations

In vivo receptor occupation by benzodiazepines and correlation with the pharmacological effect

1979 • 79 citations

Seizure inhibition by median raphe nucleus stimulation in rat

1974 • 79 citations

Kindling‐Related Changes in Afterdischarge “Thresholds”

1976 • 76 citations

A Study of the Action of Valproic Acid on the Kindling Effect

1977 • 76 citations

Amygdala kindling induces muscarinic cholinergic receptor declines in a highly specific distribution within the limbic system

1980 • 73 citations

Amygdala kindling in rats: Facilitation after local amygdala norepinephrine depletion with 6-hydroxydopamine

1980 • 73 citations

Amygdala lesions and CER learning: Long term effect of kindling

1972 • 71 citations

Effects of γ-acetylenic GABA and γ-vinyl GABA on metrazol-activated, and kindled seizures

1979 • 69 citations

Effects of midbrain raphe lesions or systemic p-chlorophenylalanine on the development of kindled seizures in rats

1979 • 69 citations

Anticonvulsant action of acute morphine administration in rats.

1976 • 67 citations

Alcohol withdrawal seizures: Implications of kindling

1980 • 65 citations

The effect of amygdala kindling on spontaneous and cocaine-induced motor activity and lidocaine seizures

1981 • 63 citations

Amygdaloid Kindling and the GABA System

1980 • 61 citations

Modification of the anticonvulsant efficacy of diazepam by Ro-15-1788 in the kindled amygdaloid seizure model

1982 • 61 citations

Electrically induced seizure activity in the hippocampus: Time course for postseizure inhibition of subsequent kindled seizures

1978 • 60 citations

Repeated administration of subconvulsant doses of GABA antagonist drugs

1982 • 57 citations

Kindling effect and sleep organization in cats

1975 • 57 citations

Soluble benzodiazepine receptors: Gabaergic regulation

1980 • 55 citations

Phencyclidine inhibition of the rate of development of amygdaloid kindled seizures

1982 • 55 citations

THE EFFECTS OF PSYCHOTHERAPEUTIC COMPOUNDS ON CENTRAL AFFERENT AND LIMBIC PATHWAYS

1957 • 52 citations

Release of γ-aminobutyric acid from hippocampal slices of the rat following generalized seizures induced by daily electrical stimulation of entorhinal cortex

1977 • 52 citations

Analgesia produced by stimulation of limbic structures and its relation to epileptiform after-discharges

1978 • 52 citations

Facilitation of amygdaloid kindling by lesions of the stria terminalis

1977 • 51 citations

Facilitation of amygdala kindling in the rat by transecting ascending noradrenergic pathways

1980 • 51 citations

Controlled demonstration of metrazol kindling

1977 • 49 citations

The Benzodiazepine Receptor

1981 • 49 citations

Pharmacological investigation of gamma-aminobutyric acid (gaba) and fully-developed generalized seizures in the amygdala-kindled rat

1982 • 49 citations

Cumulative after-discharge as the principal factor in the acquisition of kindled seizures

1981 • 49 citations

Naloxone and the kindling of seizures

1979 • 48 citations

Bilateral kindled amygdala foci and inhibitory avoidance behavior in rats: A functional lesion effect

1977 • 48 citations

The effects of chronic cocaine pretreatment on kindled seizures and behavioral stereotypies

1979 • 46 citations

Effects of Kindling or Brain Stimulation on Pentylenetetrazol‐Induced Convulsion Susceptibility

1980 • 44 citations

Opiate modification of amygdaloid-kindled seizures in rats

1982 • 44 citations

Neurotransmitters and receptor binding in amygdaloid kindled rats: Serotonergic and noradrenergic modulatory effects

1980 • 43 citations

Evidence for an agonist independent down regulation of hippocampal muscarinic receptors in kindling

1980 • 42 citations

Effect of atropine sulfate on amygdaloid kindling in the rat

1979 • 42 citations

Reduction in tyrosine hydroxylase activity in the rat amygdala induced by kindling stimulation

1978 • 42 citations

Kindling as a model for limbic epilepsy

1981 • 41 citations

Muscarinic kindling: Transsynaptic generation of a chronic seizure focus

1980 • 38 citations

Serotonergic mechanisms in amygdaloid-kindled seizures in the rat

1982 • 38 citations

Cerebral free amino acids in the amygdaloid kindling model of epilepsy

1982 • 37 citations

Pharmacological investigation of γ-aminobutyric acid (GABA) and the development of amygdala-kindled seizures in the rat

1981 • 36 citations

Sleep and kindling: II. Effects of generalized seizure induction

1981 • 36 citations

Failure of atropine to retard amygdaloid kindling

1976 • 35 citations

Inhibition of Amygdaloid Kindling by Chronic Pretreatment with Cocaine or Methamphetamine

1980 • 34 citations

Petit mal and grand mal seizures produced by toluene or benzene intoxication in the cat

1979 • 32 citations

Electrophysiologic interactions of antipsychotic drugs with central noradrenergic pathways

1981 • 31 citations

Intertrial intervals and kindled seizures

1981 • 31 citations

Inhibition of kindling-induced generalized seizures by aminooxyacetic acid

1980 • 31 citations

Biochemical evidence of decreased muscarinic cholinergic neuronal communication following amygdala-kindled seizures

1981 • 30 citations

The anticonvulsant effects of diazepam and phenobarbital in prekindled and kindled seizures in rats

1981 • 30 citations

Solubilization of the benzodiazepine receptor from rat brain

1980 • 29 citations

State-dependent learning in rats induced by kindled convulsions

1971 • 29 citations

Modification of dopaminergic receptor sensitivity in rat brain after amygdaloid kindling

1979 • 29 citations

Turnover kinetics of dopamine and norepinephrine in the forebrain after kindling in rats

1979 • 28 citations

Development of wet dog shakes during amygdala kindling in the rat

1980 • 28 citations

Participation of muscarinic cholinergic receptors may be an important requirement of the kindling process

1980 • 27 citations

The effects of pentylenetetrazol, bicuculline and strychnine on the development of kindled seizures

1982 • 27 citations

The kindled seizure: production of and modification by dieldrin in rats.

1980 • 26 citations

Enhanced rate of kindling after prolonged electrode implantation into the amygdala of rats

1982 • 24 citations

Effect of seizures kindled by subconvulsant doses of pentylenetetrazol on dopamine receptor binding and dopamine-sensitive adenylate cyclase in the rat

1981 • 22 citations

Electrical versus cholinergic kindling

1981 • 22 citations

Lasting influence of amygdaloid kindling on cholinergic neurotransmission

1982 • 22 citations

A study of the role of the cholinergic system in amygdaloid kindling in rats

1982 • 20 citations

Release of norepinephrine and dopamine from brain regions of amygdaloid-kindled rats

1980 • 20 citations

Lateralized asymmetrical state-dependent learning produced by kindled convulsions from the rat hippocampus

1981 • 20 citations

Cholinergic kindling of the amygdala requires the activation of muscarinic receptors

1981 • 20 citations

Serotonergic mechanism in seizures kindled from the rabbit amygdala

1981 • 19 citations

Effects of haloperidol-induced dopamine receptor supersensitivity on kindled seizure development.

1983 • 18 citations

Lack of effect of an opiate agonist and antagonist on the development of amygdala kindling in the rat.

1979 • 18 citations

Extra-focal catecholamine levels in ‘kindled’ rat forebrains

1981 • 18 citations

Muscarinic cholinergic regulation of epileptic spiking in kindling

1979 • 18 citations

Modification of amygdalo-cortical evoked potentials by kindling and pentetrazol-induced generalized convulsions in cats

1977 • 17 citations

Amygdaloid kindling procedure reduces severity of morphine withdrawal syndrome in rats

1980 • 17 citations

Pharmacological Investigation of Convulsant γ‐Aminobutyric Acid (GABA) Antagonists in Amygdala‐Kindled Rats

1982 • 15 citations

Cyclic nucleotides in the amygdala of the kindled rat

1981 • 15 citations

Seasonal variation in the apparent number of binding sites for 3H-opioid agonists and antagonists

1981 • 15 citations

The role of biogenic amines in amygdalar kindling. I. Local amygdalar afterdischarge.

1979 • 14 citations

Effects of amygdaloid kindling on the pain threshold of the rat

1981 • 14 citations

Kindling of motor seizures from the bed nucleus of the stria terminalis

1979 • 13 citations

Kindling-induced changes in morphine analgesia and catalepsy: Evidence for independent opioid systems

1982 • 12 citations

Locomotor and convulsive responses to picrotoxin in amygdala-kindled rats

1980 • 12 citations

Long-lasting changes in morphine sensitivity following amygdaloid kindling in mice

1981 • 12 citations

Neostigmine Activated Epileptiform Discharge in the Amygdala: Electrographie‐Behavioral Correlations

1978 • 12 citations

Effect of amygdaloid kindling on dopamine-sensitive adenylate cyclase activity in rat brain

1980 • 11 citations

Temporo-spatial pattern of subcortical spike activity in kindling epilepsy. A statistical approach

1977 • 11 citations

Chronic cholinesterase inhibition does not modify amygdaloid kindling

1981 • 10 citations

Neuronal hypersensitivity to acetylcholinesterase inhibitors induced by a kindling stimulus in the rabbit brain

1981 • 9 citations

Neuropsychological Aspects of Epilepsy

1989 • 9 citations

Post-trial barbiturates do not affect amygdaloid kindling

1979 • 9 citations

Facilitation of Kindled Seizures in Rats Fed Choline-Supplemented Diets

1983 • 8 citations

The anticonvulsant effects of diazepam and phenobarbital in prek1ndled and kindled cortical seizures

1981 • 7 citations

Pentylenetetrazol augmentation of developing kindled amygdaloid seizures

1981 • 7 citations

Effect of cocaine on afterdischarge threshold in previously kindled rats

1982 • 7 citations

Effects of single and repeated exposures to abate on rat behavior and cholinesterase activity

1979 • 7 citations

Repeated administration of subconvulsant doses of GABA antagonist drugs

1982 • 6 citations

Amygdaloid kindling and cerebrospinal cyclic nucleotides.

1981 • 4 citations

DC Potentials and Central Cyclic AMP associated with Transfer Kindling

1979 • 1 citations

Deleted Work

1955 • 0 citations