MicroRNA function in animal development

MicroRNAs

2004 • 33,206 citations

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

1993 • 12,238 citations

MicroRNA expression profiles classify human cancers

2005 • 9,457 citations

Prediction of Mammalian MicroRNA Targets

2003 • 5,070 citations

The nuclear RNase III Drosha initiates microRNA processing

2003 • 4,966 citations

Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

2002 • 4,860 citations

Identification of Novel Genes Coding for Small Expressed RNAs

2001 • 4,834 citations

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

2000 • 4,834 citations

Role for a bidentate ribonuclease in the initiation step of RNA interference

2001 • 4,804 citations

Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

2005 • 4,706 citations

Combinatorial microRNA target predictions

2005 • 4,543 citations

MicroRNA genes are transcribed by RNA polymerase II

2004 • 4,200 citations

Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

2004 • 4,068 citations

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

1993 • 4,021 citations

Human MicroRNA Targets

2004 • 3,702 citations

RAS Is Regulated by the let-7 MicroRNA Family

2005 • 3,637 citations

A microRNA polycistron as a potential human oncogene

2005 • 3,482 citations

RNA interference is mediated by 21- and 22-nucleotide RNAs

2001 • 3,271 citations

MicroRNAs Modulate Hematopoietic Lineage Differentiation

2003 • 3,241 citations

Identification of Tissue-Specific MicroRNAs from Mouse

2002 • 3,236 citations

An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans

2001 • 3,225 citations

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

2000 • 2,945 citations

Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs

2003 • 2,893 citations

An Extensive Class of Small RNAs in Caenorhabditis elegans

2001 • 2,806 citations

Asymmetry in the Assembly of the RNAi Enzyme Complex

2003 • 2,761 citations

Nuclear Export of MicroRNA Precursors

2003 • 2,662 citations

The Microprocessor complex mediates the genesis of microRNAs

2004 • 2,625 citations

A Cellular Function for the RNA-Interference Enzyme Dicer in the Maturation of the let-7 Small Temporal RNA

2001 • 2,623 citations

Argonaute2 Is the Catalytic Engine of Mammalian RNAi

2004 • 2,620 citations

Processing of primary microRNAs by the Microprocessor complex

2004 • 2,617 citations

RNAi

2000 • 2,596 citations

Functional siRNAs and miRNAs Exhibit Strand Bias

2003 • 2,516 citations

Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA

2000 • 2,422 citations

MicroRNA maturation: stepwise processing and subcellular localization

2002 • 2,410 citations

c-Myc-regulated microRNAs modulate E2F1 expression

2005 • 2,371 citations

Reduced Expression of the let-7 MicroRNAs in Human Lung Cancers in Association with Shortened Postoperative Survival

2004 • 2,341 citations

Principles of MicroRNA–Target Recognition

2005 • 2,335 citations

The microRNA Registry

2003 • 2,203 citations

The Drosha-DGCR8 complex in primary microRNA processing

2004 • 2,096 citations

A pancreatic islet-specific microRNA regulates insulin secretion

2004 • 2,054 citations

A microRNA in a Multiple-Turnover RNAi Enzyme Complex

2002 • 2,052 citations

TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

2005 • 2,046 citations

bantam Encodes a Developmentally Regulated microRNA that Controls Cell Proliferation and Regulates the Proapoptotic Gene hid in Drosophila

2003 • 2,012 citations

Identification of Mammalian microRNA Host Genes and Transcription Units

2004 • 1,966 citations

Dicer is essential for mouse development

2003 • 1,896 citations

Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals

2005 • 1,895 citations

Human Argonaute2 Mediates RNA Cleavage Targeted by miRNAs and siRNAs

2004 • 1,887 citations

Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing

2001 • 1,847 citations

A uniform system for microRNA annotation

2003 • 1,841 citations

Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs

2004 • 1,827 citations

Identification of hundreds of conserved and nonconserved human microRNAs

2005 • 1,825 citations

Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans

2001 • 1,761 citations

MicroRNA-Directed Cleavage of HOXB8 mRNA

2004 • 1,680 citations

Specificity of microRNA target selection in translational repression

2004 • 1,631 citations

Identification of Virus-Encoded MicroRNAs

2004 • 1,571 citations

Reduced accumulation of specific microRNAs in colorectal neoplasia.

2003 • 1,559 citations

MicroRNA Expression in Zebrafish Embryonic Development

2005 • 1,544 citations

Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation

2004 • 1,526 citations

Argonaute2, a Link Between Genetic and Biochemical Analyses of RNAi

2001 • 1,492 citations

Micro RNAs are complementary to 3′ UTR sequence motifs that mediate negative post-transcriptional regulation

2002 • 1,426 citations

Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis

2005 • 1,421 citations

Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes

2005 • 1,411 citations

Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs

2004 • 1,406 citations

Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs

2004 • 1,370 citations

Accumulation of miR-155 and BIC RNA in human B cell lymphomas

2005 • 1,324 citations

MicroRNAs Regulate Brain Morphogenesis in Zebrafish

2005 • 1,287 citations

Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing

2005 • 1,253 citations

siRNAs can function as miRNAs

2003 • 1,252 citations

The microRNAs ofCaenorhabditis elegans

2003 • 1,232 citations

MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies

2005 • 1,210 citations

Vertebrate MicroRNA Genes

2003 • 1,190 citations

The lin-4 Regulatory RNA Controls Developmental Timing in Caenorhabditis elegans by Blocking LIN-14 Protein Synthesis after the Initiation of Translation

1999 • 1,174 citations

Identification of microRNAs of the herpesvirus family

2005 • 1,154 citations

Embryonic Stem Cell-Specific MicroRNAs

2003 • 1,126 citations

miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs

2002 • 1,081 citations

A microRNA array reveals extensive regulation of microRNAs during brain development

2003 • 1,034 citations

MicroRNA-143 Regulates Adipocyte Differentiation

2004 • 1,007 citations

The Drosophila MicroRNA Mir-14 Suppresses Cell Death and Is Required for Normal Fat Metabolism

2003 • 1,003 citations

Human embryonic stem cells express a unique set of microRNAs

2004 • 960 citations

The Small RNA Profile during Drosophila melanogaster Development

2003 • 955 citations

MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms

2003 • 915 citations

A Cellular MicroRNA Mediates Antiviral Defense in Human Cells

2005 • 906 citations

New microRNAs from mouse and human

2003 • 881 citations

Involvement of MicroRNA in AU-Rich Element-Mediated mRNA Instability

2005 • 848 citations

The Cold Shock Domain Protein LIN-28 Controls Developmental Timing in C. elegans and Is Regulated by the lin-4 RNA

1997 • 844 citations

Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways

2004 • 831 citations

Both Natural and Designed Micro RNAs Can Inhibit the Expression of Cognate mRNAs When Expressed in Human Cells

2002 • 824 citations

The Human DiGeorge Syndrome Critical Region Gene 8 and Its D. melanogaster Homolog Are Required for miRNA Biogenesis

2004 • 815 citations

Identification of Drosophila MicroRNA Targets

2003 • 792 citations

miR-122, a Mammalian Liver-Specific microRNA, is Processed from hcr mRNA and MayDownregulate the High Affinity Cationic Amino Acid Transporter CAT-1

2004 • 786 citations

Microarray analysis of microRNA expression in the developing mammalian brain

2004 • 784 citations

The lin-41 RBCC Gene Acts in the C. elegans Heterochronic Pathway between the let-7 Regulatory RNA and the LIN-29 Transcription Factor

2000 • 761 citations

A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans

2003 • 756 citations

A custom microarray platform for analysis of microRNA gene expression

2004 • 733 citations

Computational identification of DrosophilamicroRNA genes

2003 • 724 citations

MicroRNAs and Other Tiny Endogenous RNAs in C. elegans

2003 • 702 citations

Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies

2005 • 631 citations

Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing

2004 • 623 citations

SV40-encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cells

2005 • 609 citations

Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway

2004 • 604 citations

Reduced expression of Dicer associated with poor prognosis in lung cancer patients

2005 • 586 citations

Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells

2005 • 583 citations

Sequence-Specific Inhibition of Small RNA Function

2004 • 577 citations

Identification of many microRNAs that copurify with polyribosomes in mammalian neurons

2003 • 574 citations

MicroRNA expression detected by oligonucleotide microarrays: System establishment and expression profiling in human tissues

2004 • 557 citations

microRNA biogenesis and function in plants

2005 • 546 citations

The dsRNA Binding Protein RDE-4 Interacts with RDE-1, DCR-1, and a DExH-Box Helicase to Direct RNAi in C. elegans

2002 • 538 citations

Normal microRNA Maturation and Germ-Line Stem Cell Maintenance Requires Loquacious, a Double-Stranded RNA-Binding Domain Protein

2005 • 537 citations

Dicing and slicing

2005 • 525 citations

A Large Imprinted microRNA Gene Cluster at the Mouse Dlk1-Gtl2 Domain

2004 • 509 citations

Dicer is essential for formation of the heterochromatin structure in vertebrate cells

2004 • 484 citations

The microRNA-producing enzyme Dicer1 is essential for zebrafish development

2003 • 460 citations

The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3′UTR

2004 • 441 citations

Small RNAs with Imperfect Match to Endogenous mRNA Repress Translation

2003 • 430 citations

MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression

2004 • 429 citations

Processing of Pre-microRNAs by the Dicer-1–Loquacious Complex in Drosophila Cells

2005 • 421 citations

Two Genetic Circuits Repress the Caenorhabditis elegans Heterochronic Gene lin-28 after Translation Initiation

2002 • 397 citations

Prediction and validation of microRNAs and their targets

2005 • 376 citations

Probing microRNAs with microarrays: Tissue specificity and functional inference

2004 • 375 citations

The Caenorhabditis elegans hunchback-like Gene lin-57/hbl-1 Controls Developmental Time and Is Regulated by MicroRNAs

2003 • 370 citations

The C. elegans hunchback Homolog, hbl-1, Controls Temporal Patterning and Is a Probable MicroRNA Target

2003 • 354 citations

MicroRNAs act sequentially and asymmetrically to control chemosensory laterality in the nematode

2004 • 345 citations

Depletion of Human Micro-RNA miR-125b Reveals That It Is Critical for the Proliferation of Differentiated Cells but Not for the Down-regulation of Putative Targets during Differentiation

2005 • 336 citations

Imprinted microRNA genes transcribed antisense to a reciprocally imprinted retrotransposon-like gene

2003 • 335 citations

The developmental miRNA profiles of zebrafish as determined by small RNA cloning

2005 • 326 citations

Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and Broad-Complex gene activity

2003 • 316 citations

Dicer-1 and R3D1-L catalyze microRNA maturation in Drosophila

2005 • 316 citations

Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAs

2005 • 290 citations

Computational and Experimental Identification of C. elegans microRNAs

2003 • 288 citations

microRNAs: Runts of the Genome Assert Themselves

2003 • 266 citations

The Temporal Patterning MicroRNA let-7 Regulates Several Transcription Factors at the Larval to Adult Transition in C. elegans

2005 • 260 citations

HIV-1 nef suppression by virally encoded microRNA.

2004 • 252 citations

Identification and characterization of small RNAs involved in RNA silencing

2005 • 245 citations

MicroRNA Mirn122a Reduces Expression of the Posttranscriptionally Regulated Germ Cell Transition Protein 2 (Tnp2) Messenger RNA (mRNA) by mRNA Cleavage1

2005 • 227 citations

Substrate requirements for let-7 function in the developing zebrafish embryo

2016 • 219 citations

Negative regulatory sequences in the lin-14 3'-untranslated region are necessary to generate a temporal switch during Caenorhabditis elegans development.

1991 • 207 citations

Substrate requirements for let-7 function in the developing zebrafish embryo

2004 • 205 citations

Why PLoS Became a Publisher

2003 • 203 citations

Patterns of flanking sequence conservation and a characteristic upstream motif for microRNA gene identification

2004 • 192 citations

The time of appearance of the C. elegans let-7 microRNA is transcriptionally controlled utilizing a temporal regulatory element in its promoter

2003 • 188 citations

Small RNA asymmetry in RNAi: Function in RISC assembly and gene regulation

2005 • 179 citations

Stage‐specific expression of microRNAs during Xenopus development

2004 • 163 citations

Predicting and validating microRNA targets.

2004 • 143 citations

Developmental defects by antisense-mediated inactivation of micro-RNAs 2 and 13 in Drosophila and the identification of putative target genes

2003 • 135 citations