Genetic networks that regulate development in Dictyostelium cells

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

CTR1, a negative regulator of the ethylene response pathway in arabidopsis, encodes a member of the Raf family of protein kinases

1993 • 1,894 citations

General Conclusions: Teleonomic Mechanisms in Cellular Metabolism, Growth, and Differentiation

1961 • 1,043 citations

MAP kinase pathways in yeast: For mating and more

1995 • 1,009 citations

Activation of Yeast PBS2 MAPKK by MAPKKKs or by Binding of an SH3-Containing Osmosensor

1995 • 649 citations

Chapter 2 Cultivation and Synchronous Morphogenesis of Dictyostelium under Controlled Experimental Conditions

1987 • 610 citations

Dictyostelium discoideum: A Developmental System

1977 • 505 citations

Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos

1995 • 492 citations

Tagging developmental genes in Dictyostelium by restriction enzyme-mediated integration of plasmid DNA.

1992 • 484 citations

Diversity in function and regulation of MAP kinase pathways

1994 • 469 citations

Chemical structure of the morphogen differentiation inducing factor from Dictyostelium discoideum

1987 • 371 citations

Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos.

1995 • 321 citations

Structurally distinct and stage-specific adenylyl cyclase genes play different roles in dictyostelium development

1992 • 307 citations

Developmental regulation of a dictyostelium gene encoding a protein homologous to mammalian ras protein

1984 • 267 citations

A conserved kinase cascade for MAP kinase activation in yeast

1993 • 255 citations

Regulation of Spemann organizer formation by the intracellular kinase Xgsk-3

1995 • 233 citations

Regulation and function of Gα protein subunits in Dictyostelium

1989 • 227 citations

Glycogen synthase kinase 3 regulates cell fate in dictyostelium

1995 • 221 citations

Direct induction of dictyostelium prestalk gene expression by DIF provides evidence that DIF is a morphogen

1987 • 215 citations

Intracellular pH and the control of cell differentiation in Dictyostelium discoideum

1983 • 214 citations

The G protein beta subunit is essential for multiple responses to chemoattractants in Dictyostelium.

1995 • 213 citations

A Secreted Factor and Cyclic AMP Jointly Regulate Cell-Type-Specific Gene Expression in Dictyostelium discoideum

1985 • 189 citations

Cell-Autonomous Determination of Cell-Type Choice in Dictyostelium Development by Cell-Cycle Phase

1987 • 187 citations

An analysis of culmination in Dictyostelium using prestalk and stalk-specific cell autonomous markers

1991 • 186 citations

A new anatomy of the prestalk zone in Dictyostelium

1989 • 183 citations

Origins of the prestalk-prespore pattern in Dictyostelium development

1989 • 179 citations

CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium.

1994 • 172 citations

A MAP kinase necessary for receptor-mediated activation of adenylyl cyclase in Dictyostelium.

1995 • 166 citations

Dependence of cell-type proportioning and sorting on cell cycle phase in Dictyostelium discoideum

1984 • 162 citations

Analysis of Ethylene Signal-Transduction Kinetics Associated with Seedling-Growth Response and Chitinase Induction in Wild-Type and Mutant Arabidopsis

1995 • 155 citations

An early embryonic product of the gene shaggy encodes a serine/threonine protein kinase related to the CDC28/cdc2+ subfamily.

1990 • 154 citations

Molecular genetic analysis of two G alpha protein subunits in Dictyostelium.

1991 • 153 citations

Integration of signaling information in controlling cell-fate decisions in Dictyostelium.

1995 • 149 citations

Two distinct populations of prestalk cells within the tip of the migratory Dictyostelium slug with differing fates at culmination

1993 • 148 citations

Culmination in dictyostelium is regulated by the cAMP-dependent protein kinase

1992 • 148 citations

Gene targeting of the aggregation stage cAMP receptor cAR1 in Dictyostelium.

1991 • 148 citations

A G-protein beta-subunit is essential for Dictyostelium development.

1993 • 147 citations

G protein-linked signaling pathways control the developmental program of dictyostelium

1994 • 145 citations

LagC is required for cell-cell interactions that are essential for cell-type differentiation in Dictyostelium.

1994 • 144 citations

CAR2, a prestalk cAMP receptor required for normal tip formation and late development of Dictyostelium discoideum.

1993 • 136 citations

A secreted 80 × 103M r protein mediates sensing of cell density and the onset of development in Dictyostelium

1991 • 130 citations

A developmentally regulated, putative serine/threonine protein kinase is essential for development in Dictyostelium

1991 • 129 citations

Negative regulation of Jun/AP-1: conserved function of glycogen synthase kinase 3 and the Drosophila kinase shaggy.

1993 • 128 citations

Combinatorial control of cell differentiation by cAMP and DIF-1 during development of Dictyostelium discoideum

1990 • 126 citations

Positively and negatively acting signals regulating stalk cell and anterior-like cell differentiation in dictyostelium

1991 • 123 citations

Density-dependent induction of discoidin-I synthesis in exponentially growing cells of Dictyostelium discoideum

1987 • 121 citations

Cloning and characterization of the G-box binding factor, an essential component of the developmental switch between early and late development in Dictyostelium.

1994 • 117 citations

Structural characterization of Dictyostelium discoideum prespore-specific gene D19 and of its product, cell surface glycoprotein PsA.

1988 • 109 citations

DdPK3, which plays essential roles during Dictyostelium development, encodes the catalytic subunit of cAMP-dependent protein kinase.

1992 • 108 citations

Characterization of two highly diverged but developmentally co-regulated cysteine proteinase genes inDictyostelium discoideum

1985 • 106 citations

Developmental regulation of a stalk cell differentiation-inducing factor in Dictyostelium discoideum

1982 • 104 citations

Role of phospholipase C in Dictyostelium: formation of inositol 1,4,5-trisphosphate and normal development in cells lacking phospholipase C activity.

1994 • 102 citations

Two cAMP receptors activate common signaling pathways in Dictyostelium.

1994 • 102 citations

A Dictyostelium prespore-specific gene is transcriptionally repressed by DIF in vitro

1988 • 101 citations

Phenotypic changes induced by a mutated ras gene during the development of Dictyostelium transformants

1986 • 101 citations

A STUDY OF THE CONTROL OF DIFFERENTIATION: THE PROPORTIONS OF STALK AND SPORE CELLS IN THE SLIME MOLD DICTYOSTELIUM DISCOIDEUM

1949 • 100 citations

Ligand-induced phosphorylation of the cAMP receptor from Dictyostelium discoideum.

1988 • 99 citations

Multiple roles for cAMP-dependent protein kinase during Dictyostelium development

1992 • 99 citations

Seven Helix Chemoattractant Receptors Transiently Stimulate Mitogen-activated Protein Kinase in Dictyostelium

1996 • 99 citations

The timing of cell-type-specific differentiation in Dictyostelium discoideum

1984 • 98 citations

Identification and targeted gene disruption of cAR3, a cAMP receptor subtype expressed during multicellular stages of Dictyostelium development.

1993 • 98 citations

A multidrug resistance transporter/serine protease gene is required for prestalk specialization in Dictyostelium.

1995 • 93 citations

Overexpression of the csa cell adhesion molecule under its own camp-regulated promoter impairs morphogenesis in dictyostelium

1992 • 89 citations

Induction of gene expression in Dictyostelium by prestarvation factor, a factor secreted by growing cells

1991 • 87 citations

Multiple genes for cell surface cAMP receptors in Dictyostelium discoideum

1991 • 85 citations

Progression of an inductive signal activates sporulation in Dictyostelium discoideum

1994 • 83 citations

The cAMP receptor CAR4 regulates axial patterning and cellular differentiation during late development of Dictyostelium.

1994 • 83 citations

Mutation of the third intracellular loop of the cAMP receptor, cAR1, of Dictyostelium yields mutants impaired in multiple signaling pathways.

1994 • 82 citations

Analysis of a spatially regulated phosphotyrosine phosphatase identifies tyrosine phosphorylation as a key regulatory pathway in Dictyostelium

1992 • 81 citations

Non-chemotactic Dictyostelium discoideum mutants with altered cGMP signal transduction.

1993 • 81 citations

Surface glycoprotein, gp24, involved in early adhesion of Dictyostelium discoideum

1987 • 80 citations

Identification of a DNA sequence element required for efficient expression of a developmentally regulated and cAMP-inducible gene of Dictyostelium discoideum

1987 • 80 citations

Enhancer Regions Responsible for Temporal and Cell-Type-Specific Expression of a Spore Coat Gene in Dictyostelium

1993 • 80 citations

The cyclic nucleotide phosphodiesterase gene of Dictyostelium discoideum contains three promoters specific for growth, aggregation, and late development.

1990 • 79 citations

wingless acts through the shaggy/zeste-white 3 kinase to direct dorsal-ventral axis formation in the Drosophila leg

1994 • 79 citations

Analysis of the prestarvation response in growing cells of Dictyostelium discoideum

1988 • 77 citations

cAMP-dependent protein kinase differentially regulates prestalk and prespore differentiation during Dictyostelium development

1993 • 75 citations

The Dictyostelium MAP kinase ERK2 regulates multiple, independent developmental pathways.

1996 • 75 citations

Cell Type Regulation in Response to Expression of ricin A in Dictyostelium

1993 • 74 citations

Immunological analysis of a glycoprotein (contact sites A) involved in intercellular adhesion of dictyostelium discoideum

1981 • 74 citations

Identification of the sequences controlling cyclic AMP regulation and cell-type-specific expression of a prestalk-specific gene in Dictyostelium discoideum.

1987 • 74 citations

Expression of cAMP-dependent protein kinase in prespore cells is sufficient to induce spore cell differentiation in Dictyostelium.

1994 • 72 citations

Coordinate regulation of the spore coat genes in Dictyostelium discoideum

1991 • 70 citations

Mitochondrial DNA replication but no nuclear DNA replication during development of Dictyostelium.

1995 • 68 citations

1 Lateral Inhibition and Pattern Formation in Dictyostelium

1993 • 67 citations

The target of ammonia action in dictyostelium

1993 • 67 citations

Serpentine cAMP receptors may act through a G protein-independent pathway to induce postaggregative development in dictyostelium

1995 • 64 citations

The surface cyclic AMP receptors, cAR1, cAR2, and cAR3, promote Ca2+ influx in Dictyostelium discoideum by a G alpha 2-independent mechanism.

1993 • 64 citations

cAMP signal transduction pathways regulating development of Dictyostelium discoideum

1991 • 63 citations

Chapter 3 Genetic Tools for Dictyostelium discoideum

1987 • 63 citations

Mutations Affecting a Surface Glycoprotein, gp80, of Dictyostelium discoideum

1984 • 59 citations

Signal transduction pathways controlling multicellular development in Dictyostelium

1991 • 59 citations

Identification and Functional Analysis of a Developmentally Regulated Extracellular Signal-Regulated Kinase Gene in Dictyostelium discoideum

1994 • 59 citations

Identification of CRAC, a cytosolic regulator required for guanine nucleotide stimulation of adenylyl cyclase in Dictyostelium.

1994 • 59 citations

Two transmembrane signaling mechanisms control expression of the cAMP receptor gene CAR1 during Dictyostelium development.

1993 • 58 citations

Pattern formation in Dictyostelium discoideum: An analysis of mutants altered in cell proportioning

1981 • 58 citations

A repressor controls the timing and spatial localisation of stalk cell-specific gene expression in Dictyostelium

1993 • 58 citations

A developmentally regulated trans-acting factor recognizes dissimilar G/C-rich elements controlling a class of cAMP-inducible Dictyostelium genes.

1990 • 57 citations

Amino acid substitutions in the Dictyostelium G alpha subunit G alpha 2 produce dominant negative phenotypes and inhibit the activation of adenylyl cyclase, guanylyl cyclase, and phospholipase C.

1992 • 57 citations

Whole-Mount in Situ Hybridization of Cell-Type-Specific mRNAs in Dictyostelium

1995 • 55 citations

Spore coat genes SP60 and SP70 of Dictyostelium discoideum.

1989 • 55 citations

Two DIF-inducible, prestalk-specific mRNAs of Dictyostelium encode extracellular matrix proteins of the slug

1988 • 54 citations

A developmentally regulated cell surface receptor for a density-sensing factor in Dictyostelium.

1994 • 51 citations

Effect of growth conditions on development of the cellular slime mould, Dictyostelium discoideum

1972 • 51 citations

Initial Cell Type Divergence inDictyosteliumIs Independent of DIF-1

1996 • 51 citations

Developmental and spatial regulation of a Dictyostelium prespore gene: cis-acting elements and a cAMP-induced, developmentally regulated DNA binding activity

1991 • 50 citations

Spatial and temporal regulation of a foreign gene by a prestalk-specific promoter in transformed Dictyostelium discoideum.

1986 • 50 citations

Structural and functional characterization of aDictyostetiumgene encoding a DIF inducible, prestalk-enriched mRNA sequence

1987 • 49 citations

DIF-1 induces its own breakdown in Dictyostelium.

1992 • 49 citations

Identification and localization of proteins encoded by two DIF-inducible genes of Dictyostelium

1988 • 46 citations

An 80-bp cis-acting regulatory region controls cAMP and development regulation of a prestalk gene in Dictyostelium.

1988 • 46 citations

MAP Kinase Pathways: Straight and narrow or tortuous and intersecting?

1994 • 46 citations

A trans-acting factor required for cAMP-induced gene expression in Dictyostelium is regulated developmentally and induced by cAMP.

1989 • 45 citations

Disruption of the sporulation-specific gene spiA in Dictyostelium discoideum leads to spore instability.

1992 • 43 citations

Identification of sequences regulating the transcription of aDictyostcliumgene selectively expressed in prespore cells

1989 • 43 citations

Regulation of Cell-type-specific Gene Expression in Dictyostelium

1985 • 42 citations

Dictyostelium discoideum: Cell-type proportioning, cell-differentiation preference, cell fate, and the behavior of anterior-like cells in Hs1/Hs2 and G+/G− mixtures

1986 • 42 citations

The correlation of cellular changes with succinic dehydrogenase and cytochrome oxidase activities in the development of the cellular slime molds

1960 • 41 citations

Monoclonal antibodies against contact sites A of Dictyostelium discoideum: detection of modifications of the glycoprotein in tunicamycin-treated cells

1982 • 41 citations

Extracellular cAMP can restore development in Dictyostelium cells lacking one, but not two subtypes of early cAMP receptors (cARs). Evidence for involvement of cAR1 in aggregative gene expression

1994 • 41 citations

The cAMP Receptor Subtype cAR2 Is Restricted to a Subset of Prestalk Cells duringDictyosteliumDevelopment and Displays Unexpected DIF-1 Responsiveness

1996 • 40 citations

The Effect of Divalent Cations on Aggregation of Dictyostelium discoideum

1979 • 39 citations

Regulation and processing of a secreted protein that mediates sensing of cell density in Dictyostelium

1991 • 38 citations

Developmental regulation of transcription of a novel prespore-specific gene (Dp87) in Dictyostelium discoideum

1993 • 37 citations

Cytoplasmic acidification facilitates but does not mediate DIF-induced prestalk gene expression in Dictyostelium discoideum

1990 • 37 citations

A localized differentiation-inducing-factor sink in the front of the Dictyostelium slug.

1993 • 36 citations

A G-rich sequence element common to Dictyostelium genes which differ radically in their patterns of expression

1992 • 36 citations

Cyclic nucleotide phosphodiesterase of Dictyostelium discoideum and its glycoprotein inhibitor: Structure and expression of their genes

1991 • 36 citations

Regulation by protein-tyrosine phosphatase PTP2 is distinct from that by PTP1 during Dictyostelium growth and development.

1994 • 35 citations

A GBF-binding site and a novel AT element define the minimal sequences sufficient to direct prespore-specific expression in Dictyostelium discoideum.

1994 • 35 citations

Regulation of slug size by the cell adhesion molecule gp80 in Dictyostelium discoideum.

1990 • 34 citations

Sequence of theDictyostelium discoideumspore coat gene SP96

1989 • 34 citations

Protein kinase A is a positive regulator of spore coat gene transcription in Dictyostelium

1995 • 34 citations

Growing and starving Dictyostelium cells produce distinct density-sensing factors

1992 • 34 citations

Cell-cycle regulation of center initiation in Dictyostelium discoideum

1986 • 33 citations

G‐proteins in the signal‐transduction pathways of Dictyostelium discoideum

1988 • 33 citations

Pattern Formation in a Cell‐Cycle Dependent Manner during the Development of Dictyostelium discoideum

1993 • 31 citations

The effect of ammonia on cell-type-specific enzyme accumulation in Dictyostelium discoideum

1989 • 30 citations

Regulatory role of the Gα1 subunit in controlling cellular morphogenesis in Dictyostelium

1994 • 29 citations

Disruption of the Gene Encoding the EcmA, Extracellular Matrix Protein of Dictyostelium Alters Slug Morphology

1994 • 29 citations

Characterization of a novel Dictyostelium discoideum prespore-specific gene, PspB, reveals conserved regulatory sequences

1994 • 29 citations

PARASEXUAL GENETIC ANALYSIS OF CELL PROPORTIONING MUTANTS OF DICTYOSTELIUM DISCOIDEUM

1981 • 26 citations

Identification of a signal transduction response sequence element necessary for induction of a Dictyostelium discoideum gene by extracellular cyclic AMP.

1989 • 25 citations

Inhibition of receptor-stimulated guanylyl cyclase by intracellular calcium ions in Dictyostelium cells

1992 • 23 citations

A Ca²⁺‐dependent signal transduction system participates in coupling expression of some cAMP‐dependent prespore genes to the cell surface receptor

1988 • 22 citations

Ammonia hypersensitivity of slugger mutants of D. discoideum

1994 • 21 citations

Identification of a New Spore Coat Protein Gene in the Cellular Slime Mold Dictyostelium discoideum

1994 • 17 citations

A Role for cAMP-Dependent Protein Kinase in Determining the Stability of Prespore Cell Differentiation in Dictyostelium

1994 • 17 citations

[Anticholinesterase activity of oxidation products of dithiophosphoric acid (M-74)].

1962 • 17 citations

Regulation of the Dictyostelium cAMP-induced, prestalk-specific DdrasD gene: identification of cis-acting elements

1992 • 17 citations

Developmentally regulated changes in 1,2-diacylglycerol in Dictyostelium. Regulation by light and G proteins

1993 • 16 citations

The cyclic nucleotide phosphodiesterase of Dictyostelium discoideum: The structure of the gene and its regulation and role in development

1988 • 16 citations

G-Protein-linked Signaling Pathways Mediate Development in Dictyostelium

1992 • 15 citations

Spatial and temporal expression of the Dictyostelium discoideum G alpha protein subunit G alpha 2: expression of a dominant negative protein inhibits proper prestalk to stalk differentiation.

1994 • 12 citations

Redundant regulatory elements account for the developmental control of a ribosomal protein gene of Dictyostelium discoideum

1994 • 10 citations

Deactivation of gene expression upon the onset of development in Dictyostelium discoideum

1988 • 10 citations

The Promoter of a Gene Encoding a Novel Dictyostelium Spore Coat Protein

1994 • 9 citations

Distribution of cAMP-dependent protein kinase during development in Dictyostelium discoideum

1987 • 8 citations

Regulation of guanylate cyclase by a guanine nucleotide binding protein, Gα2, in Dictyostelium discoideum

1991 • 7 citations