MAP Kinase Pathways: Straight and narrow or tortuous and intersecting?

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase

1994 • 1,370 citations

An Osmosensing Signal Transduction Pathway in Yeast

1993 • 1,252 citations

A two-component system that regulates an osmosensing MAP kinase cascade in yeast

1994 • 1,091 citations

Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation.

1993 • 992 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27

1994 • 866 citations

Complex formation between RAS and RAF and other protein kinases.

1993 • 633 citations

An Osmosensing Signal Transduction Pathway in Mammalian Cells

1994 • 584 citations

Elements of the Yeast Pheromone Response Pathway Required for Filamentous Growth of Diploids

1993 • 505 citations

Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae

1994 • 499 citations

Involvement of growth factor receptors in the mammalian UVC response

1994 • 456 citations

A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signalling by protein kinase C.

1993 • 373 citations

Ras-dependent growth factor regulation of MEK kinase in PC12 cells

1994 • 322 citations

MKK1 and MKK2, Which Encode Saccharomyces cerevisiae Mitogen-Activated Protein Kinase-Kinase Homologs, Function in the Pathway Mediated by Protein Kinase C

1993 • 306 citations

Complexes between STE5 and components of the pheromone-responsive mitogen-activated protein kinase module.

1994 • 243 citations

MKK1 and MKK2, which encode Saccharomyces cerevisiae mitogen-activated protein kinase-kinase homologs, function in the pathway mediated by protein kinase C.

1993 • 187 citations

Inhibition of v-raf-dependent c-fos expression and transformation by a kinase-defective mutant of the mitogen-activated protein kinase Erk2.

1994 • 186 citations

Bacterial lipopolysaccharide has structural similarity to ceramide and stimulates ceramide-activated protein kinase in myeloid cells

1994 • 142 citations

Reconstitution of a yeast protein kinase cascade in vitro: activation of the yeast MEK homologue STE7 by STE11.

1994 • 122 citations

Raf-1 forms a stable complex with Mek1 and activates Mek1 by serine phosphorylation.

1993 • 121 citations

Evidence that inactive p42 mitogen-activated protein kinase and inactive Rsk exist as a heterodimer in vivo.

1994 • 116 citations

Affinity-purified c-Jun amino-terminal protein kinase requires serine/threonine phosphorylation for activity.

1992 • 109 citations

pp54 microtubule-associated protein-2 kinase requires both tyrosine and serine/threonine phosphorylation for activity

1991 • 108 citations

Conservation and reiteration of a kinase cascade

1993 • 104 citations

Sex, stress and integrity: the importance of MAP kinases in yeast

1994 • 75 citations

Tyrosine phosphorylation of a yeast 40 kDa protein occurs in response to mating pheromone.

1991 • 24 citations