1 Lateral Inhibition and Pattern Formation in Dictyostelium

Positional information and the spatial pattern of cellular differentiation

1969 • 2,957 citations

A gradient of bicoid protein in Drosophila embryos

1988 • 1,015 citations

Antisense RNA Inactivation of Myosin Heavy Chain Gene Expression in Dictyostelium discoideum

1987 • 677 citations

The bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryo

1989 • 672 citations

The Development of Dictyostelium Discoideum

1982 • 664 citations

Chapter 6 Positional Information and Pattern Formation

1971 • 663 citations

Positional Information and Pattern Formation

2016 • 646 citations

Dictyostelium discoideum: A Developmental System

1977 • 505 citations

Dictyostelium discoideum: A developmental system

1975 • 401 citations

Chemical structure of the morphogen differentiation inducing factor from Dictyostelium discoideum

1987 • 371 citations

Transcriptional regulation of a pair-rule stripe in Drosophila.

1991 • 354 citations

Experiments on the development of the fore limb of Amblystoma, a self‐differentiating equipotential system

1918 • 330 citations

Regulation of a Segmentation Stripe by Overlapping Activators and Repressors in the Drosophila Embryo

1991 • 321 citations

Lateral inhibition and the development of the sensory bristles of the adult peripheral nervous system of Drosophila

1990 • 316 citations

Organogenesis-A Biophysical View

1980 • 315 citations

Cell differentiation without morphogenesis in Dictyostelium discoideum

1976 • 311 citations

Local and General Factors in the Development of “Pattern” in Rhodnius Prolixus (Hemiptera)

1940 • 309 citations

Developmental regulation of a dictyostelium gene encoding a protein homologous to mammalian ras protein

1984 • 267 citations

Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva

1991 • 246 citations

CYCLIC AMP AND OTHER SIGNALS CONTROLLING CELL DEVELOPMENT AND DIFFERENTIATION IN DICTYOSTELIUM

1987 • 240 citations

Lateral inhibition during vulval induction in Caenorhabditis elegans

1988 • 218 citations

Direct induction of dictyostelium prestalk gene expression by DIF provides evidence that DIF is a morphogen

1987 • 215 citations

Intracellular pH and the control of cell differentiation in Dictyostelium discoideum

1983 • 214 citations

Three-dimensional scroll waves organize Dictyostelium slugs.

1992 • 209 citations

Cell lineage conversion in the sea urchin embryo

1988 • 208 citations

Optimization and in situ detection of Escherichia coli β-galactosidase gene expression in Dictyostelium discoideum

1989 • 200 citations

Limitation of the size of the vulval primordium of Caenorhabditis elegans by lin-15 expression in surrounding hypodermis

1990 • 198 citations

A Secreted Factor and Cyclic AMP Jointly Regulate Cell-Type-Specific Gene Expression in Dictyostelium discoideum

1985 • 189 citations

Fate and regulation of anterior-like cells in Dictyostelium slugs

1982 • 188 citations

Cell-Autonomous Determination of Cell-Type Choice in Dictyostelium Development by Cell-Cycle Phase

1987 • 187 citations

The Prestalk-Prespore Pattern in Cellular Slime Molds

1979 • 187 citations

An analysis of culmination in Dictyostelium using prestalk and stalk-specific cell autonomous markers

1991 • 186 citations

A new anatomy of the prestalk zone in Dictyostelium

1989 • 183 citations

A possible morphogen controlling differentiation in Dictyostelium

1983 • 180 citations

Origins of the prestalk-prespore pattern in Dictyostelium development

1989 • 179 citations

Entwicklungs- und Bewegungsphysiologie der Pflanze

1953 • 157 citations

The orientation to light and the extermely sensitive orientation to temperature gradients in the slime mold Dictyostelium discoideum

1950 • 148 citations

Molecular phylogeny of Dictyostelium discoideum by protein sequence comparison.

1990 • 144 citations

G protein linked signal transduction pathways in development: Dictyostelium as an experimental system

1989 • 144 citations

A spatial gradient of expression of a cAMP-regulated prespore cell-type-specific gene in Dictyostelium.

1990 • 132 citations

A developmentally regulated, putative serine/threonine protein kinase is essential for development in Dictyostelium

1991 • 129 citations

A secreted factor and cyclic AMP jointly regulate cell-type-specific gene expression in Dictyostelium discoideum.

1985 • 126 citations

Combinatorial control of cell differentiation by cAMP and DIF-1 during development of Dictyostelium discoideum

1990 • 126 citations

Positively and negatively acting signals regulating stalk cell and anterior-like cell differentiation in dictyostelium

1991 • 123 citations

Interactions between adenosine and oscillatory cAMP signaling regulate size and pattern in Dictyostelium

1986 • 123 citations

Density-dependent induction of discoidin-I synthesis in exponentially growing cells of Dictyostelium discoideum

1987 • 121 citations

Cell sorting out during the differentiation of mixtures of metabolically distinct populations ofDictyostelium discoideum

1973 • 118 citations

Dictyostelium mutants lacking DIF, a putative morphogen

1983 • 110 citations

Structural characterization of Dictyostelium discoideum prespore-specific gene D19 and of its product, cell surface glycoprotein PsA.

1988 • 109 citations

DdPK3, which plays essential roles during Dictyostelium development, encodes the catalytic subunit of cAMP-dependent protein kinase.

1992 • 108 citations

Phenotypic changes induced by a mutated ras gene during the development of Dictyostelium transformants

1986 • 101 citations

A Dictyostelium prespore-specific gene is transcriptionally repressed by DIF in vitro

1988 • 101 citations

Ligand-induced phosphorylation of the cAMP receptor from Dictyostelium discoideum.

1988 • 99 citations

Multiple roles for cAMP-dependent protein kinase during Dictyostelium development

1992 • 99 citations

Cyclic AMP is an inhibitor of stalk cell differentiation in Dictyostelium discoideum

1988 • 99 citations

The timing of cell-type-specific differentiation in Dictyostelium discoideum

1984 • 98 citations

Molecular characterization of anterior-like cells in Dictyostelium discoideum

1985 • 96 citations

Two-phase regulatory pathway controls cAMP receptor-mediated expression of early genes in Dictyostelium.

1989 • 93 citations

Nature and distribution of the morphogen DIF in the Dictyostelium slug

1987 • 93 citations

cAMP and cell sorting control the spatial expression of a developmentally essential cell-type-specific ras gene in Dictyostelium.

1991 • 90 citations

Evidence that positional information is used to establish the prestalk-prespore pattern in Dictyostelium discoideum aggregates

1984 • 88 citations

Selective elimination of the contact site A protein of Dictyostelium discoideum by gene disruption.

1989 • 85 citations

Dedifferentiation of iris epithelial cells

1972 • 82 citations

Chemotactic sorting to cAMP in the multicellular stages of Dictyostelium development.

1992 • 82 citations

Enhancer Regions Responsible for Temporal and Cell-Type-Specific Expression of a Spore Coat Gene in Dictyostelium

1993 • 80 citations

Surface glycoprotein, gp24, involved in early adhesion of Dictyostelium discoideum

1987 • 80 citations

Growing and developing Dictyostelium cells express different ras genes.

1989 • 78 citations

Spore coat proteins of Dictyostelium discoideum are packaged in prespore vesicles

1983 • 77 citations

Analysis of the prestarvation response in growing cells of Dictyostelium discoideum

1988 • 77 citations

CELL TYPE CONVERSION IN ISOLATED PRESTALK AND PRESPORE FRAGMENTS OF THE CELLULAR SLIME MOLD DICTYOSTELIUM DISCOIDEUM

1973 • 77 citations

The early development of Arenicola and Sternaspis

1900 • 74 citations

Morphogen hunting in Dictyostelium

1989 • 71 citations

Coordinate regulation of the spore coat genes in Dictyostelium discoideum

1991 • 70 citations

Differential synthesis of spore coat proteins in prespore and prestalk cells of Dictyostelium.

1982 • 65 citations

A role for cAMP-dependent protein kinase A in early Dictyostelium development.

1990 • 64 citations

Control of phototactic migration in Dictyostelium discoideum

1973 • 63 citations

A specific DIF binding protein in Dictyostelium.

1990 • 63 citations

Prestalk and prespore differentiation in Dictyostelium as detected by cell type-specific monoclonal antibodies

1983 • 63 citations

Pattern formation in Dictyostelium discoideum: An analysis of mutants altered in cell proportioning

1981 • 58 citations

Plasma membrane proteins ofDictyostelium: The spore coat proteins

1979 • 58 citations

Localization of Cyclic Nucleotide Phosphodiesterase in the Multicellular Stages of Dictyostelium discoideum* *This research was supported by Grant Number AG00677, awarded by the National Institute on Aging

1980 • 58 citations

Cell cycle phase in Dictyostelium discoideum is correlated with the expression of cyclic AMP production, detection, and degradation

1988 • 57 citations

A model for the prestalk/prespore patterning in the slug of the slime mold Dictyostelium discoideum

1983 • 56 citations

Spore coat genes SP60 and SP70 of Dictyostelium discoideum.

1989 • 55 citations

In Vivo Receptor-Mediated Phosphorylation of a G Protein in Dictyostelium

1990 • 55 citations

Two DIF-inducible, prestalk-specific mRNAs of Dictyostelium encode extracellular matrix proteins of the slug

1988 • 54 citations

Adenosine and its derivatives inhibit the cAMP signaling response in Dictyostelium discoideum

1984 • 53 citations

The cyclic nucleotide phosphodiesterase inhibitory protein of Dictyostelium discoideum. Purification and characterization.

1981 • 50 citations

Developmental and spatial regulation of a Dictyostelium prespore gene: cis-acting elements and a cAMP-induced, developmentally regulated DNA binding activity

1991 • 50 citations

Dictyostelium amoebae can differentiate into spores without cell-to-cell contact

1981 • 50 citations

A prespore gene, Dd31, expressed during culmination of Dictyostelium discoideum

1991 • 50 citations

Structural and functional characterization of aDictyostetiumgene encoding a DIF inducible, prestalk-enriched mRNA sequence

1987 • 49 citations

DIF-1 induces its own breakdown in Dictyostelium.

1992 • 49 citations

Inositol trisphosphate and diacylglycerol can differentially modulate gene expression in Dictyostelium.

1989 • 49 citations

Adhesion mutants of Dictyostelium discoideum lacking the saccharide determinant recognized by two adhesion-blocking monoclonal antibodies

1985 • 48 citations

Identification and localization of proteins encoded by two DIF-inducible genes of Dictyostelium

1988 • 46 citations

Identification of sequences regulating the transcription of aDictyostcliumgene selectively expressed in prespore cells

1989 • 43 citations

Selective induction of stalk-cell-specific proteins in Dictyostelium

1985 • 42 citations

Dictyostelium discoideum: Cell-type proportioning, cell-differentiation preference, cell fate, and the behavior of anterior-like cells in Hs1/Hs2 and G+/G− mixtures

1986 • 42 citations

Mutant RAS gene induces elevated levels of inositol tris-and hexakisphosphates in Dictyostelium

1988 • 41 citations

Formation of the Dictyostelium spore coat

1990 • 41 citations

Cell‐cell adhesion in Dictyostelium discoideum

1988 • 39 citations

Pattern formation in Dictyostelium discoideum:II. Differentiation and pattern formation in non-polar aggregates

1977 • 38 citations

Cytoplasmic acidification facilitates but does not mediate DIF-induced prestalk gene expression in Dictyostelium discoideum

1990 • 37 citations

Differentiation of Dictyostelium discoideum in monolayer cultures and its modification by ionic conditions

1984 • 37 citations

pdsA, a gene involved in the production of active phosphodiesterase during starvation of Dictyostelium discoideum amoebae

1980 • 36 citations

Monoclonal antibody recognizing gp80, a membrane glycoprotein implicated in intercellular adhesion of Dictyostelium discoideum.

1983 • 36 citations

A localized differentiation-inducing-factor sink in the front of the Dictyostelium slug.

1993 • 36 citations

Sequence of theDictyostelium discoideumspore coat gene SP96

1989 • 34 citations

Cell-cycle regulation of center initiation in Dictyostelium discoideum

1986 • 33 citations

Differentiation‐inducing‐factor dechlorinase, a novel cytosolic dechlorinating enzyme from Dictyostelium discoideum

1992 • 32 citations

Cell Proportioning and Pattern Formation

1982 • 32 citations

Specificity of adenosine inhibition of cAMP-induced responses in Dictyostelium resembles that of the P site of higher organisms

1986 • 31 citations

The effect of ammonia on cell-type-specific enzyme accumulation in Dictyostelium discoideum

1989 • 30 citations

Unexpected localisation of cells expressing a prespore marker of Dictyostelium discoideum

1991 • 30 citations

A developmentally regulated and cAMP-repressible gene of Dictyostelium discoideum: cloning and expression of the gene encoding cyclic nucleotide phosphodiesterase inhibitor

1990 • 30 citations

Characterization of anterior-like cells in Dictyostelium as analyzed by their movement

1986 • 29 citations

Localization and levels of cyclic AMP during development of Dictyostelium discoideum

1984 • 28 citations

PARASEXUAL GENETIC ANALYSIS OF CELL PROPORTIONING MUTANTS OF DICTYOSTELIUM DISCOIDEUM

1981 • 26 citations

Separation of Dictyostelium discoideum cells into density classes throughout their development and their relationship to the later cell types

1984 • 26 citations

Monoclonal antibodies specific for stalk differentiation in Dictyostelium discoideum

1984 • 26 citations

Dictyostelium discoideum mutant Synag 7 with altered g-protein–adenylate cyclase interaction

1988 • 26 citations

Correlations between prestalk-prespore tendencies and cAMP-related activities in Dictyostelium discoideum

1982 • 24 citations

Four billion years: an essay on the evolution of genes and organisms

1988 • 24 citations

Diffusible signal molecules controlling cell differentiation and patterning in Dictyostelium

1991 • 23 citations

Signals controlling cell differentiation and pattern formation in Dictyostelium

1988 • 23 citations

The effect of cAMP on differentiation inducing factor (DIF)-mediated formation of stalk cells in low-cell-density monolayers of Dictyostelium discoideum

1988 • 22 citations

Prestalk/prespore differentiation tendency of Dictyostelium discoideum cells as detected by a stalk-specific monoclonal antibody

1985 • 22 citations

Two Feedback Loops May Regulate Cell-type Proportions in Dictyostelium

1985 • 22 citations

A Ca²⁺‐dependent signal transduction system participates in coupling expression of some cAMP‐dependent prespore genes to the cell surface receptor

1988 • 22 citations

Opposite effects of adenosine on two types of cAMP‐induced gene expression in Dictyostelium indicate the involvement of at least two different intracellular pathways for the transduction of cAMP signals

1988 • 21 citations

An attempt to analyze the phenomena of polarity in Tubularia

1904 • 20 citations

Control of cell type proportions by a secreted factor in Dictyostelium discoideum

1989 • 20 citations

A Dictyostelium morphogen that is essential for stalk cell formation is generated by a subpopulation of prestalk cells

1990 • 19 citations

Experimentally induced aberrations in the pattern of differentiation in the cellular slime mould Dictyostelium discoideum

1974 • 18 citations

Patterning processes in aggregates of hydra cells visualized with the monoclonal antibody, TS19

1990 • 18 citations

Cell-cell interactions in Dictyostelium development

1989 • 18 citations

Regulation of Cell-type-specific Differentiation in Dictyostelium

1985 • 16 citations

Isolation and characterization of spore coat protein (sp96) gene of Dictyostelium discoideum

1990 • 16 citations

Ligand-induced modification of a surface cAMP receptor of Dictyostelium discoideum does not require its occupancy.

1988 • 15 citations

Protein binding and DNase-I-hypersensitive sites in the cis-acting regulatory region of the spore-coat SP96 gene of Dictyostelium

1992 • 14 citations

Transmembrane signal transduction pathways in Dictyostelium.

1991 • 13 citations

Two independent promoters as well as 5′untranslated regions regulate Ddrasexpression inDictyostellium

1991 • 13 citations

cAMP regulation of the expression of prespore-specific genes, SP96 and Dp87, in disaggregated slug cells of Dictyostelium discoideum

1990 • 12 citations

Developmental expression and characterization of the gene encoding spore coat protein SP60 in Dictyostelium discoideum

1990 • 12 citations

The synthesis and degradation of ras-related gene products during growth and differentiation in Dictyostelium discoideum

1987 • 9 citations

Essential Genes for Development ofDictyostelium

1990 • 9 citations

Distribution of cAMP-dependent protein kinase during development in Dictyostelium discoideum

1987 • 8 citations

Cellular responsiveness to cyclic AMP in a phosphodiesterase-defective mutant of Dictyostelium discoideum

1982 • 5 citations

Signals that regulate differentiation in dictyostelium

1988 • 5 citations

Complete nucleotide sequence of a DIF-inducible, stalk-specific mRNA fromDictyostelium discoideum

1988 • 3 citations

Effects of normal and mutant ras genes on inositol lipid metabolism in Dictyostelium

1991 • 3 citations