Mutational analysis of an autoantibody: differential binding and pathogenicity.

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

Sequences of proteins of immunological interest

1984 • 3,427 citations

Sequence-specific recognition of double helical nucleic acids by proteins.

1976 • 1,123 citations

The role of clonal selection and somatic mutation in autoimmunity

1987 • 714 citations

Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation.

1990 • 672 citations

Avidity of anti-DNA antibodies in serum and IgG glomerular eluates from patients with systemic lupus erythematosus. Association of high avidity antinative DNA antibody with glomerulonephritis.

1977 • 409 citations

Molecular events during maturation of the immune response to oxazolone

1985 • 380 citations

Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity.

1984 • 344 citations

Restricted subpopulations of DNA antibodies in kidneys of mice with systemic lupus

1980 • 268 citations

An autoantibody to single‐stranded DNA: Comparison of the three‐dimensional structures of the unliganded fab and a deoxynucleotide–fab complex

1991 • 256 citations

Murine monoclonal anti-DNA antibodies bind directly to glomerular antigens and form immune deposits.

1987 • 249 citations

Somatic mutations in the variable regions of a human IgG anti-double-stranded DNA autoantibody suggest a role for antigen in the induction of systemic lupus erythematosus.

1991 • 246 citations

Framework residue 71 is a major determinant of the position and conformation of the second hypervariable region in the VH domains of immunoglobulins

1990 • 238 citations

Anti-DNA antibodies form immune deposits at distinct glomerular and vascular sites

1992 • 217 citations

Comparison of pathogenic and non-pathogenic murine antibodies to DNA: antigen binding and structural characteristics

1994 • 150 citations

Direct measurement of antibody affinity distribution by Haften-inhibition enzyme immunoassay

1984 • 129 citations

Structural correlates of high antibody affinity: three engineered amino acid substitutions can increase the affinity of an anti-p-azophenylarsonate antibody 200-fold.

1990 • 103 citations

Mutations in Immunoglobulin-Producing Moose Myeloma Cells

1973 • 99 citations

Molecular characterization of a somatically mutated anti-DNA antibody bearing two systemic lupus erythematosus-related idiotypes.

1990 • 96 citations

A novel class of anti-DNA antibodies identified in BALB/c mice.

1991 • 92 citations

Interclonal and intraclonal diversity among anti-DNA antibodies from an (NZB x NZW)F1 mouse.

1990 • 79 citations

Recurrent somatic mutations in mouse antibodies to p-azophenylarsonate increase affinity for hapten.

1989 • 77 citations

V region sequences of an idiotypically connected family of pathogenic anti-DNA autoantibodies.

1990 • 71 citations

Structural similarity of antibody variable regions from immune and autoimmune anti-DNA antibodies.

1993 • 62 citations

Variable region framework differences result in decreased or increased affinity of variant anti-digoxin antibodies.

1988 • 59 citations

Significant structural and functional change of an antigen-binding site by a distant amino acid substitution: proposal of a structural mechanism.

1989 • 57 citations

Isolation of hybridomas expressing a specific heavy chain variable region gene segment by using a screening technique that detects mRNA sequences in whole cell lysates.

1984 • 54 citations

Characterization of somatically mutated S107 VH11-encoded anti-DNA autoantibodies derived from autoimmune (NZB x NZW)F1 mice.

1991 • 50 citations

Correlation of DNA-anti-DNA association rates with clinical activity in systemic lupus erythematosus (SLE).

1981 • 48 citations

Somatic diversification of the S107 (T15) VH11 germ-line gene that encodes the heavy-chain variable region of antibodies to double-stranded DNA in (NZB x NZW)F1 mice.

1988 • 41 citations

CLINICAL SIGNIFICANCE OF ANTI–DOUBLE‐STRANDED DNA ANTIBODIES DETECTED BY A SOLID PHASE ENZYME IMMUNOASSAY

1981 • 40 citations

Different interactions used by Cro repressor in specific and nonspecific DNA binding.

1986 • 36 citations

The invariant tryptophan in an H chain V region is not essential to antibody binding.

1988 • 16 citations