Molecular Analysis of Rearranged VH Genes during B Cell Chronic Lymphocytic Leukemia: Intraclonal Stability is Frequent but not Constant

Sequences of proteins of immunological interest

1984 • 3,427 citations

Somatic generation of antibody diversity

1983 • 3,275 citations

Recent Advances in the Polymerase Chain Reaction

1991 • 1,068 citations

Early Restriction of the Human Antibody Repertoire

1987 • 546 citations

Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse.

1987 • 473 citations

A clinical trial of anti-idiotype therapy for B cell malignancy

1985 • 434 citations

Evidence that multiple myeloma Ig heavy chain VDJ genes contain somatic mutations but show no intraclonal variation

1992 • 330 citations

B-cell chronic lymphocytic leukemia: present status and future directions. French Cooperative Group on CLL

1991 • 298 citations

Clustering of extensive somatic mutations in the variable region of an immunoglobulin heavy chain gene from a human B cell lymphoma

1986 • 279 citations

Emergence of Idiotype Variants during Treatment of B-Cell Lymphoma with Anti-Idiotype Antibodies

1985 • 257 citations

Clonal evolution of a follicular lymphoma: evidence for antigen selection.

1992 • 255 citations

Developmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia.

1989 • 239 citations

Human Immunoglobulin Heavy-Chain Variable Region Genes: Organization, Polymorphism, and Expression

1991 • 229 citations

Organization and evolution of variable region genes of the human immunoglobulin heavy chain

1986 • 227 citations

B-cell chronic lymphocytic leukemia: present status and future directions. French Cooperative Group on CLL

1991 • 218 citations

The smaller human VH gene families display remarkably little polymorphism.

1989 • 203 citations

Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region.

1980 • 199 citations

Autoantibody-associated kappa light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation. Implications for etiology and immunotherapy.

1988 • 177 citations

Continuing rearrangement but absence of somatic hypermutation in immunoglobulin genes of human B cell precursor leukemia.

1988 • 160 citations

Immunoglobulin heavy chain variable region family usage is independent of tumor cell phenotype in human B lineage leukemias

1990 • 158 citations

VH gene rearrangement events can modify the immunoglobulin heavy chain during progression of B-lineage acute lymphoblastic leukemia [see comments]

1992 • 123 citations

Physical map of the 3′ region of the human immunoglobulin heavy chain locus: clustering of autoantibody-related variable segments in one haplotype.

1991 • 115 citations

Lack of detectable somatic hypermutation in the V region of the Ig H chain gene of a human chronic B lymphocytic leukemia.

1988 • 91 citations

The BALB/c secondary response to the Sb site of influenza virus hemagglutinin. Nonrandom silent mutation and unequal numbers of VH and Vk mutations.

1990 • 55 citations

Idiotype variant cell populations in patients with B cell lymphoma.

1986 • 52 citations

Absence of Ig V region gene somatic hypermutation in advanced Burkitt's lymphoma.

1989 • 48 citations

Variable region gene analysis of an isotype-switched (IgA) variant of chronic lymphocytic leukemia

1992 • 38 citations

The pattern of joining (JH) gene usage in the human IgH chain is established predominantly at the B precursor cell stage.

1992 • 35 citations

Autoantibody-encoding kappa L chain genes frequently rearranged in lambda L chain-expressing chronic lymphocytic leukemia.

1991 • 28 citations

B cell development in chronic lymphocytic leukemia.

1987 • 23 citations

Sequence analysis of members of the human Ig VH4 gene family derived from a single VH locus. Identification of novel germ-line members.

1992 • 22 citations