EFFECTS OF MORPHINE ON METHOTREXATE DISPOSITION IN MICE

Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man.

1966 • 1,363 citations

Applied Biopharmaceutics and Pharmacokinetics.

1981 • 1,335 citations

Cardiovascular Response to Large Doses of Intravenous Morphine in Man

1969 • 397 citations

Clinical Toxicology of Commercial Products.

1976 • 278 citations

The effect of organic acids on renal clearance of methotrexate in man

1969 • 267 citations

7-Hydroxymethotrexate as a urinary metabolite in human subjects and rhesus monkeys receiving high dose methotrexate.

1976 • 256 citations

Isolation of a Family of Organic Anion Transporters from Human Liver and Kidney

2001 • 202 citations

Cloning and Functional Characterization of a Novel Rat Organic Anion Transporter Mediating Basolateral Uptake of Methotrexate in the Kidney

1996 • 199 citations

Drug dosage in laboratory animals: A handbook

1966 • 151 citations

High-dose methotrexate with citrovorum factor rescue: predictive value of serum methotrexate concentrations and corrective measures to avert toxicity.

1977 • 124 citations

The Cancer Chemotherapy Handbook

2004 • 113 citations

Prolongation and enhancement of serum methotrexate concentrations by probenecid.

1978 • 109 citations

Pharmacokinetics of methotrexate and 7-hydroxymethotrexate following infusions of high-dose methotrexate.

1982 • 87 citations

Drug Interactions Analysis and Management 2009

2009 • 78 citations

Cancer pain management current strategy

1993 • 74 citations

Pharmacokinetics of high-dose methotrexate with citrovorum factor rescue.

1977 • 61 citations

Some observations on the human pharmacology of methotrexate.

1977 • 47 citations

Morphine Effects on Cardiac Output and Regional Blood Flow Distribution in Conscious Dogs

1981 • 37 citations

Effect of penicillin on the renal tubular secretion of methotrexate in the monkey.

1984 • 36 citations

Pharmacokinetics of methotrexate and 7-hydroxy-methotrexate in rabbits after intravenous administration

1983 • 31 citations

Pharmacodynamics of High-Dose Methotrexate in Pediatric Patients

2002 • 30 citations

The effect of niosomes and polysorbate 80 on the metabolism and excretion of methotrexate in the mouse

1986 • 29 citations

Renal tubular transport of methotrexate in the rhesus monkey and dog.

1979 • 29 citations

Dose dependent methotrexate elimination following bolus intravenous injection

1980 • 28 citations

Pharmacokinetics of methotrexate and 7-hydroxy-methotrexate in rabbits

1985 • 23 citations

Pharmacokinetics of methotrexate (MTX) and 7-hydroxymethotrexate (7-OH-MTX) in rats and evidence for the metabolism of MTX to 7-OH-MTX

1989 • 20 citations

Evidence for Nonlinear Pharmacokinetics of Methotrexate in the Rat

1982 • 18 citations

Role of opioid peptides and subfornical organ in the renal function of intact and hypophysectomized rats

1992 • 14 citations

Role of endogenous peripheral opioid mechanisms in renal function.

1994 • 14 citations

Opioid effects on hepatic disposition of dyes in mice.

1985 • 13 citations

Opiate effects on 5-fluorouracil disposition in mice

1996 • 11 citations

Methotrexate and 7-hydroxymethotrexate: serum level monitoring by high-performance liquid chromatography.

1980 • 10 citations

Narcotic effects on hepatic disposition of sulfobromophthalein in rats.

1983 • 10 citations

Narcotic effects on phenol red disposition in mice.

1981 • 9 citations

Effects of morphine and clonidine on sulphobromophthalein disposition in mice

1986 • 7 citations

A novel acute toxicity resulting from the administration of morphine and Adriamycin to mice

1987 • 6 citations

Effects of morphine on the renal handling of sodium and lithium in conscious rats.

1990 • 5 citations

Tolerance to morphine effects on renal disposition of xenobiotics in mice.

1986 • 4 citations