Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse

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1997 • 2,510 citations

REGULATION OF IMMUNE RESPONSES BY TGF-β

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Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.

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Murine Models of Systemic Lupus Erythematosus

1985 • 1,572 citations

Histone-deacetylase inhibitors: novel drugs for the treatment of cancer

2002 • 1,497 citations

Histone Deacetylase Inhibitors: Inducers of Differentiation or Apoptosis of Transformed Cells

2000 • 1,158 citations

Histone deacetylase inhibitor selectively induces p21 ^WAF1 expression and gene-associated histone acetylation

2000 • 1,091 citations

A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases

1998 • 899 citations

What's Up and Down with Histone Deacetylation and Transcription?

1997 • 831 citations

Deacetylation of p53 modulates its effect on cell growth and apoptosis

2000 • 794 citations

IκB-β regulates the persistent response in a biphasic activation of NF-κB

1995 • 780 citations

Methylation of Histone H4 at Arginine 3 Facilitating Transcriptional Activation by Nuclear Hormone Receptor

2001 • 758 citations

Modulation of Chromatin Structure Regulates Cytokine Gene Expression during T Cell Differentiation

1998 • 697 citations

The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation.

1996 • 662 citations

Uncoupling of Immune Complex Formation and Kidney Damage in Autoimmune Glomerulonephritis

1998 • 621 citations

Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo.

2000 • 608 citations

Continuous administration of anti-interleukin 10 antibodies delays onset of autoimmunity in NZB/W F1 mice.

1994 • 543 citations

Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3

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Structure of the human immune interferon gene

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The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines

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Cloning and expression of murine immune interferon cDNA.

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The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine.

1994 • 447 citations

Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1

2001 • 441 citations

Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo.

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In vivo treatment of (NZB X NZW)F1 lupus-like nephritis with monoclonal antibody to gamma interferon.

1987 • 396 citations

Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling

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Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice.

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Decoding the nucleosome

1993 • 342 citations

Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci.

1992 • 339 citations

RPD3 encodes a second factor required to achieve maximum positive and negative transcriptional states in Saccharomyces cerevisiae.

1991 • 315 citations

Multiple Control Elements Mediate Activation of the Murine and Human Interleukin 12 p40 Promoters: Evidence of Functional Synergy between C/EBP and Rel Proteins

1997 • 310 citations

Role of covalent modifications of histones in regulating gene expression

1999 • 305 citations

Activation of MHC Class I, II, and CD40 Gene Expression by Histone Deacetylase Inhibitors

2000 • 279 citations

Increased Ser-10 Phosphorylation of Histone H3 in Mitogen-stimulated and Oncogene-transformed Mouse Fibroblasts

1999 • 268 citations

Altered Histone Acetylation atGlutamate Receptor 2andBrain-Derived Neurotrophic FactorGenes Is an Early Event Triggered by Status Epilepticus

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Cytokines and systemic lupus erythematosus

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Interleukin 6 promotes murine lupus in NZB/NZW F1 mice.

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In vivo cytokine gene expression in T cell subsets of the autoimmune MRL/Mp‐lpr/lpr mouse

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Induction of anti-double stranded DNA antibodies in normal mice by immunization with bacterial DNA.

1989 • 202 citations

Modulation of Renal Disease in MRL/lpr Mice Genetically Deficient in the Alternative Complement Pathway Factor B

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Experimental therapy of systemic lupus erythematosus: the treatment of NZB/W mice with mouse soluble interferon‐γ receptor inhibits the onset of glomerulonephritis

1995 • 188 citations

Rapid and Selective Remodeling of a Positioned Nucleosome during the Induction of IL-12 p40 Transcription

1999 • 184 citations

Trichostatin A reverses skewed expression of CD154, interleukin-10, and interferon-γ gene and protein expression in lupus T cells

2001 • 179 citations

Distinct Methylation of the Interferon γ (IFN-γ) and Interleukin 3 (IL-3) Genes in Newly Activated Primary CD8+ T Lymphocytes: Regional IFN-γ Promoter Demethylation and mRNA Expression Are Heritable in CD44highCD8+ T Cells

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Age-associated increase in interleukin 6 in MRL/lpr mice

1991 • 164 citations

Genes modulated by histone acetylation as new effectors of butyrate activity

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The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL/MP-lpr/lpr mice.

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Quantitative polymerase chain reaction analysis reveals marked overexpression of interleukin-1β, interleukin-10 and interferon-γ mRNA in the lymph nodes of lupus-prone mice

1995 • 120 citations

Histone Deacetylases Augment Cytokine Induction of the iNOS Gene

2002 • 108 citations

RPD3 Encodes a Second Factor Required To Achieve Maximum Positive and Negative Transcriptional States in Saccharomyces cerevisiae

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Histone deacetylase inhibitors suppress IL-2–mediated gene expression prior to induction of apoptosis

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Cloning and structure of the human immune interferon-gamma chromosomal gene.

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Flow cytometric analysis of G₁‐ and G₂/M‐phase subpopulations in mammalian cell nuclei using side scatter and DNA content measurements

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Inhibition of histone deacetylase activity by trichostatin A modulates gene expression during mouse embryogenesis without apparent toxicity.

2001 • 88 citations

Decoding the nucleosome

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Lupus : molecular and cellular pathogenesis

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Animal Models of Systemic Lupus Erythematosus

1994 • 69 citations

Loss of PU.1 Expression Following Inhibition of Histone Deacetylases

2001 • 66 citations

Granulocyte-Colony Stimulating Factor Treatment of Lupus Autoimmune Disease in MRL-lpr/lpr Mice

1999 • 48 citations

Effects of histone acetylation on transcriptional regulation of manganese superoxide dismutase gene

2002 • 45 citations

High-level expression of IkB-b in the surface epithelium of the colon: in vitro evidence for an immunomodulatory role

1999 • 40 citations

Effect of trichostatin A on human T cells resembles signaling abnormalities in T cells of patients with systemic lupus erythematosus: A new mechanism for TCR ζ chain deficiency and abnormal signaling*†

2002 • 39 citations

Association of Deficient Type II Protein Kinase A Activity with Aberrant Nuclear Translocation of the RIIβ Subunit in Systemic Lupus Erythematosus T Lymphocytes

2000 • 39 citations

IGF-II Enhances Trichostatin A-Induced TGFβ1 and p21Waf1,Cip1,Sdi1 Expression in Hep3B Cells

1999 • 37 citations

A flow cytometry-based assay for quantitative analysis of cellular proliferation and cytotoxicity in vitro

2002 • 35 citations

Lymphoid Transcription of the Murine CD21 Gene Is Positively Regulated by Histone Acetylation

1999 • 26 citations

Histone deacetylase inhibition results in decreased macrophage CD9 expression

2002 • 22 citations

Cytokines in the Immunopathogenesis of Lupus

1999 • 20 citations

Differential Effects of Histone Deacetylase Inhibitors on Interleukin-18 Gene Expression in Myeloid Cells

2002 • 19 citations