Quantitative polymerase chain reaction analysis reveals marked overexpression of interleukin-1β, interleukin-10 and interferon-γ mRNA in the lymph nodes of lupus-prone mice

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

1991 • 3,812 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

IL-10 inhibits cytokine production by activated macrophages.

1991 • 2,919 citations

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

Interleukin-10

1993 • 1,820 citations

Murine Models of Systemic Lupus Erythematosus

1985 • 1,572 citations

Analysis of cytokine mRNA and DNA: detection and quantitation by competitive polymerase chain reaction.

1990 • 1,484 citations

The Molecular Cell Biology of Interferon-gamma and its Receptor

1993 • 1,323 citations

The cytokine handbook

1994 • 1,121 citations

Protection from Fas-Mediated Apoptosis by a Soluble Form of the Fas Molecule

1994 • 1,120 citations

Continuous administration of anti-interleukin 10 antibodies delays onset of autoimmunity in NZB/W F1 mice.

1994 • 543 citations

Ly‐1 B (B‐1) cells are the main source of B cell‐derived interleukin 10

1992 • 525 citations

Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway.

1990 • 509 citations

Production of cytokines by mouse B cells: B lymphomas and normal B cells produce interleukin 10

1990 • 347 citations

The mouse fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster

1994 • 335 citations

Cytokine profile in systemic lupus erythematosus, rheumatoid arthritis, and other rheumatic diseases

1993 • 265 citations

Cytokine gene expression after in vivo primary immunization with goat antibody to mouse IgD antibody.

1991 • 250 citations

In vivo cytokine gene expression in T cell subsets of the autoimmune MRL/Mp‐lpr/lpr mouse

1990 • 219 citations

Differential regulation of transforming growth factor beta and interleukin 2 genes in human T cells: demonstration by usage of novel competitor DNA constructs in the quantitative polymerase chain reaction.

1991 • 206 citations

Differential cytokine expression in acute and chronic murine graft‐versus‐host‐disease

1993 • 194 citations

Identification of a B cell differentiation factor(s) spontaneously produced by proliferating T cells in murine lupus strains of the lpr/lpr genotype.

1983 • 188 citations

Preferential activation of Th2 cells in chronic graft-versus-host reaction.

1993 • 187 citations

Serum levels of interferons in patients with systemic lupus erythematosus.

1987 • 180 citations

The Molecular Pathology of Autoimmune Diseases

2002 • 163 citations

Correction of accelerated autoimmune disease by early replacement of the mutated lpr gene with the normal Fas apoptosis gene in the T cells of transgenic MRL-lpr/lpr mice.

1994 • 145 citations

Analysis of cytokine mRNA levels in interleukin‐4‐transgenic mice by quantitative polymerase chain reaction

1992 • 139 citations

B cell dependence on and response to accessory signals in murine lupus strains.

1983 • 108 citations

Local cytokine production in a murine model of Escherichia coli pyelonephritis.

1992 • 93 citations

Cytokine abnormalities in human lupus

1992 • 93 citations

Dysregulated expression of the T cell cytokine Eta-1 in CD4-8- lymphocytes during the development of murine autoimmune disease.

1990 • 75 citations

The Molecular Pathology of Autoimmune Diseases

1993 • 66 citations

Invariant chain alters the malignant phenotype of MHC class II+ tumor cells.

1992 • 61 citations

The abnormal T lymphocytes in lpr mice transcribe interferon‐γ and tumor necrosis factor‐α genes spontaneously in vivo

1989 • 59 citations

Cytokine gene expression in mice undergoing chronic graft-versus-host disease

1993 • 56 citations

Class-specific regulation of anti-DNA antibody synthesis and the age-associated changes in (NZB x NZW)F1 hybrid mice.

1987 • 55 citations

Increased autoantibody production by NZB/NZW B cells in response to IL-5.

1988 • 52 citations

Use of quantitative polymerase chain reaction to quantitate cytokine messenger RNA molecules

1992 • 40 citations

IgG1 and IgG2a production by autoimmune B cells treated in vitro with IL-4 and IFN-gamma.

1990 • 39 citations

Cytokines and anti-cytokines

1989 • 38 citations

Competitor mRNA fragments for quantitation of cytokine specific transcripts in cell lysates

1993 • 33 citations

An autosomal recessive gene that delays expression of lupus in BXSB mice.

1991 • 27 citations

Clonal analysis of gene expression by PCR.

1990 • 27 citations

Determinants of B cell hyperactivity in murine lupus.

1988 • 17 citations

Molecular genetics of murine lupus

1986 • 4 citations