Glutamatergic neurotransmission involves structural and clinical deficits of schizophrenia

The Brief Psychiatric Rating Scale

1962 • 10,683 citations

Subanesthetic Effects of the Noncompetitive NMDA Antagonist, Ketamine, in Humans

1994 • 3,182 citations

Recent advances in the phencyclidine model of schizophrenia

1991 • 2,886 citations

Negative Symptoms in Schizophrenia

1982 • 2,228 citations

Glutamate Receptor Dysfunction and Schizophrenia

1995 • 1,682 citations

Physiological and pathophysiological roles of excitatory amino acids during central nervous system development

1990 • 1,427 citations

Schizophrenia After Prenatal Famine

1996 • 740 citations

Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia

1980 • 703 citations

Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies

1991 • 625 citations

NMDA-dependent modulation of CA1 local circuit inhibition

1996 • 481 citations

Abnormal Excitatory Neurotransmitter Metabolism in Schizophrenic Brains

1995 • 458 citations

Magnetic Resonance Imaging of the Brain in Schizophrenia

1990 • 440 citations

Ventricular enlargement in schizophrenia: relationship to positive and negative symptoms

1982 • 435 citations

N -Acetylaspartate in neuropsychiatric disorders

1995 • 422 citations

Excitotoxic Amino Acids and Neuropsychiatric Disorders

1990 • 407 citations

Schizophrenia – a Brain Disease? a Critical Review of Structural and Functional Cerebral Abnormality in the Disorder

1995 • 345 citations

Neurobiology of Cerebrospinal Fluid.

1981 • 343 citations

Computed Tomography in Schizophreniform Disorder and Other Acute Psychiatric Disorders

1982 • 326 citations

CEREBRAL VENTRICULAR SIZE IN TWINS DISCORDANT FOR SCHIZOPHRENIA

1982 • 313 citations

The NMDA-receptor antagonist CPP abolishes neurogenic ‘wind-up pain’ after intrathecal administration in humans

1992 • 302 citations

A “Glutamatergic Hypothesis” of Schizophrenia

1989 • 270 citations

Poor premorbid adjustment and CT scan abnormalities in chronic schizophrenia

1980 • 258 citations

Structural brain abnormalities in the major psychoses: A quantitative review of the evidence from computerized imaging.

1990 • 245 citations

Dose-finding trial of D-cycloserine added to neuroleptics for negative symptoms in schizophrenia

1995 • 238 citations

Current outcome in schizophrenia: women vs men

1986 • 211 citations

Glutamate and related acidic excitatory neurotransmitters: from basic science to clinical application

1987 • 195 citations

D-cycloserine added to clozapine for patients with schizophrenia

1996 • 184 citations

Ventricular Enlargement in Schizophrenia

1992 • 178 citations

Ventricular Enlargement in Schizophrenia Evaluated With Computed Tomographic Scanning

1990 • 167 citations

Computerised Tomography in Schizophrenia 15 Years On

1990 • 161 citations

Genetic and Perinatal Determinants of Structural Brain Deficits in Schizophrenia

1989 • 155 citations

Lateral ventricular enlargement associated with persistent unemployment and negative symptoms in both schizophrenia and bipolar disorder

1984 • 149 citations

Rhesus Incompatibility as a Risk Factor for Schizophrenia in Male Adults

1996 • 147 citations

Rat brain N-acetylated alpha-linked acidic dipeptidase activity. Purification and immunologic characterization.

1990 • 128 citations

Dopamine-β-Hydroxylase Activity and Homovanillic Acid in Spinal Fluid of Schizophrenics with Brain Atrophy

1983 • 125 citations

Positron emission tomography in aging and dementia: effect of cerebral atrophy.

1987 • 118 citations

Normal cerebrospinal fluid and brain glutamate levels in schizophrenia do not support the hypothesis of glutamatergic neuronal dysfunction

1982 • 112 citations

Evidence for an endogenous peptide ligand for the phencyclidine receptor

1984 • 102 citations

The Phencyclidine-Glutamate Model of Schizophrenia

1995 • 102 citations

Obstetric Complications and Schizophrenia: A Case Control Study Based on Standardised Obstetric Records

1996 • 100 citations

Temporal lobe proton magnetic resonance spectroscopy of patients with first-episode psychosis

1995 • 90 citations

Cerebrospinal fluid amino acid concentrations in chronic schizophrenia

1987 • 76 citations

Low-concentration N-acetylaspartylglutamate suppresses the climbing fiber response of Purkinje cells in Guinea pig cerebellar slices and the responses to excitatory amino acids of Xenopus laevis oocytes injected with cerebellar mRNA

1989 • 75 citations

Multidimensional analysis of the concentrations of 17 substances in the CSF of schizophrenics and controls

1985 • 72 citations

Amino acid patterns in schizophrenia: Some new findings

1990 • 70 citations

N-acetyl-aspartylglutamate modulation of N-methyl-D-aspartate-stimulated [3H]norepinephrine release from rat hippocampal slices.

1993 • 70 citations

BRAIN IMAGING IN SCHIZOPHRENIA

1995 • 68 citations

Glutamate in schizophrenics and healthy controls

1982 • 60 citations

Structural brain pathology in schizophrenia revisited *1Prefrontal cortex pathology is inversely correlated with cerebrospinal fluid levels of homovanillic acid

1987 • 54 citations

Glycinergic augmentation of NMDA receptor-mediated neurotransmission in the treatment of schizophrenia.

1996 • 53 citations

CSF Dopamine β-Hydroxylase in Schizophrenia

1983 • 44 citations

A Viral-Anatomical Explanation of Schizophrenia

1991 • 42 citations

CSF dopamine beta-hydroxylase in schizophrenia: associations with premorbid functioning and brain computerized tomography scan measures

1994 • 42 citations

Immunocytochemical distribution of n-acetylaspartylglutamate in the rat forebrain and glutamatergic pathways

1993 • 35 citations

An endogenous ligand of the brain σ/PCP receptor antagonizes NMDA-induced neurotransmitter release

1987 • 34 citations

Relationships between clinical effects and monoamine metabolites and amino acids in sulpiride-treated schizophrenic patients

1990 • 32 citations

Monoamine metabolites and amino acids in serum from schizophrenic patients before and during sulpiride treatment

1989 • 31 citations

Cerebral Glutamate, Neuroleptic Drugs and Schizophrenia: Increase of Cerebrospinal Fluid Glutamate Levels and Decrease of Striate Body Glutamate Levels following Sulpiride Treatment in Rats

1983 • 25 citations

d-CPPene (SDZ EAA-494)—A Competitive NMDA Antagonist

1997 • 25 citations

Structural Brain Abnormalities in the Major Psychoses

1989 • 15 citations

Computed tomography measurements of brain density in schizophrenia

1991 • 3 citations