Metalloproteases regulate T-cell proliferation and effector function via LAG-3

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

1997 • 3,094 citations

Matrix metalloproteinases as modulators of inflammation and innate immunity

2004 • 1,833 citations

An Essential Role for Ectodomain Shedding in Mammalian Development

1998 • 1,607 citations

Germline Mutations in the Extracellular Domains of the 55 kDa TNF Receptor, TNFR1, Define a Family of Dominantly Inherited Autoinflammatory Syndromes

1999 • 1,363 citations

Role of LAG-3 in Regulatory T Cells

2004 • 1,198 citations

Metalloproteinase inhibitors: biological actions and therapeutic opportunities

2002 • 1,159 citations

Validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy

2006 • 1,157 citations

Constitutive and regulated α-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease

1999 • 1,115 citations

A Novel Proteolytic Cleavage Involved in Notch Signaling

2000 • 1,080 citations

ADAMs: key components in EGFR signalling and development

2005 • 1,056 citations

The ADAMs family of metalloproteases: multidomain proteins with multiple functions

2003 • 1,052 citations

Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

2004 • 965 citations

LAG-3, a novel lymphocyte activation gene closely related to CD4.

1990 • 802 citations

Development of Matrix Metalloproteinase Inhibitors in Cancer Therapy

2001 • 788 citations

TNF-α mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity

2002 • 740 citations

TNF-α mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity

2002 • 664 citations

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

2002 • 657 citations

ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and β-catenin translocation

2005 • 630 citations

γ-Secretase: proteasome of the membrane?

2004 • 543 citations

Functional Analysis of the Domain Structure of Tumor Necrosis Factor-α Converting Enzyme

2000 • 496 citations

ADAMs: focus on the protease domain

1998 • 472 citations

ADAM10 cleavage of N-cadherin and regulation of cell–cell adhesion and β-catenin nuclear signalling

2005 • 470 citations

Adam Meets Eph: An ADAM Substrate Recognition Module Acts as a Molecular Switch for Ephrin Cleavage In trans

2005 • 434 citations

Requirements for Presenilin-Dependent Cleavage of Notch and Other Transmembrane Proteins

2000 • 418 citations

Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling

2003 • 414 citations

Protein Kinase Cθ in T Cell Activation

2002 • 351 citations

Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases.

1994 • 338 citations

Lymphocyte Activation Gene-3 (CD223) Regulates the Size of the Expanding T Cell Population Following Antigen Activation In Vivo

2004 • 328 citations

Cutting Edge: Molecular Analysis of the Negative Regulatory Function of Lymphocyte Activation Gene-3

2002 • 328 citations

Protein Kinase C θ Affects Ca2+ Mobilization and NFAT Activation in Primary Mouse T Cells

2003 • 320 citations

The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein–coupled receptors

2002 • 318 citations

Negative Regulation of T Cell Homeostasis by Lymphocyte Activation Gene-3 (CD223)

2005 • 306 citations

The CD4‐related molecule, LAG‐3 (CD223), regulates the expansion of activated T cells

2003 • 289 citations

Characterization of the major histocompatibility complex class II binding site on LAG-3 protein

1997 • 267 citations

TNFRSF1A mutations and autoinflammatory syndromes

2000 • 243 citations

Phenotypic analysis of the murine CD4-related glycoprotein, CD223 (LAG-3)

2002 • 220 citations

ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23

2006 • 200 citations

Transforming growth factor-alpha and beta-amyloid precursor protein share a secretory mechanism.

1995 • 144 citations

Intramembrane proteolysis controls diverse signalling pathways throughout evolution

2002 • 142 citations

Protein kinase ctheta cooperates with calcineurin to induce Fas ligand expression during activation-induced T cell death.

1999 • 131 citations

Biochemical Analysis of the Regulatory T Cell Protein Lymphocyte Activation Gene-3 (LAG-3; CD223)

2004 • 122 citations

Protein Kinase Cθ Cooperates with Calcineurin to Induce Fas Ligand Expression During Activation-Induced T Cell Death

1999 • 105 citations

Protein kinase C-θ: signaling from the center of the T-cell synapse

2002 • 104 citations

Biochemical properties and functions of membrane-anchored metalloprotease-disintegrin proteins (ADAMs)

2003 • 91 citations

Regulation of expression of the human lymphocyte activation gene-3 ( LAG-3 ) molecule, a ligand for MHC class II

1998 • 90 citations

Metalloproteinase Shedding of Fas Ligand Regulates β-Amyloid Neurotoxicity

2002 • 62 citations

The inhibition of metalloproteinases as a therapeutic target in rheumatoid arthritis and osteoarthritis

2001 • 56 citations

Profound Enhancement of T Cell Activation Mediated by the Interaction Between the TCR and the D3 Domain of CD4

1999 • 51 citations

Loss of Ectodomain Shedding Due to Mutations in the Metalloprotease and Cysteine-rich/Disintegrin Domains of the Tumor Necrosis Factor-α Converting Enzyme (TACE)

2004 • 49 citations

Genomic organization of the human LAG-3/CD4 locus

1997 • 46 citations

Inactivating mutations block the tumor necrosis factor-α-converting enzyme in the early secretory pathway

2004 • 25 citations

Protein Kinase C Forms a Complex with and Phosphorylates the GTPase Activating Protein Gap:

1993 • 17 citations