Mitochondria and ageing

Mitochondria and Apoptosis

1998 • 8,909 citations

Aging: A Theory Based on Free Radical and Radiation Chemistry

1956 • 8,252 citations

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Mitochondrial Diseases in Man and Mouse

1999 • 3,008 citations

The mitochondrial permeability transition

1995 • 2,412 citations

Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG

1991 • 2,172 citations

Oxidative damage and mitochondrial decay in aging.

1994 • 2,024 citations

The Biologic Clock: The Mitochondria?

1972 • 1,912 citations

AN UNSOLVED PROBLEM OF BIOLOGY

1953 • 1,832 citations

8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions.

1992 • 1,830 citations

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

1995 • 1,761 citations

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

1988 • 1,709 citations

Why do we age?

2000 • 1,696 citations

Extension of Life-Span by Overexpression of Superoxide Dismutase and Catalase in Drosophila melanogaster

1994 • 1,461 citations

Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine.

1990 • 1,100 citations

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

1994 • 1,020 citations

Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice.

1996 • 1,020 citations

Mitochondrial role in cell aging

1980 • 919 citations

Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

1992 • 878 citations

Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons

1998 • 852 citations

Mitochondria as regulators of apoptosis: doubt no more

1998 • 838 citations

Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

1994 • 785 citations

Detection of a specific mitochondrial DNA deletion in tissues of older humans

1990 • 784 citations

Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues

1987 • 778 citations

Oxidative damage to mitochondrial DNA shows marked age‐dependent increases in human brain

1993 • 759 citations

DECLINE IN SKELETAL MUSCLE MITOCHONDRIAL RESPIRATORY CHAIN FUNCTION: POSSIBLE FACTOR IN AGEING

1989 • 722 citations

Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome

1990 • 687 citations

A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues.

1992 • 633 citations

Mitochondrial disease in superoxide dismutase 2 mutant mice

1999 • 581 citations

A mouse model for mitochondrial myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator

1997 • 554 citations

Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals

2000 • 536 citations

Determination of Life-Span in Caenorhabditis elegans by Four Clock Genes

1996 • 529 citations

Mitochondria and programmed cell death: back to the future

1996 • 508 citations

A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase

1998 • 497 citations

MOLECULAR GENETIC ASPECTS OF HUMAN MITOCHONDRIAL DISORDERS

1995 • 486 citations

Increased mitochondrial oxidative stress in the Sod2 (+/−) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis

2001 • 478 citations

Mammalian mitochondrial genetics: heredity, heteroplasmy and disease

1997 • 469 citations

FLP Recombinase-Mediated Induction of Cu/Zn-Superoxide Dismutase Transgene Expression Can Extend the Life Span of Adult Drosophila melanogaster Flies

1999 • 462 citations

Increased Oxidative Damage Is Correlated to Altered Mitochondrial Function in Heterozygous Manganese Superoxide Dismutase Knockout Mice

1998 • 454 citations

Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis

1996 • 440 citations

The Broad Spectrum of Responses to Oxidants in Proliferating Cells: A New Paradigm for Oxidative Stress

1999 • 432 citations

Untitled

1997 • 432 citations

Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing.

1995 • 406 citations

Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death.

1999 • 385 citations

Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease

1992 • 354 citations

Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence

1990 • 345 citations

The future of ageing

2000 • 336 citations

Random Intracellular Drift Explains the Clonal Expansion of Mitochondrial DNA Mutations with Age

2001 • 332 citations

Analyses of mitochondrial respiratory chain function and mitochondrial DNA deletion in human skeletal muscle: Effect of ageing

1992 • 329 citations

Decline with age of the respiratory chain activity in human skeletal muscle

1994 • 325 citations

Hypoxemia Is Associated With Mitochondrial DNA Damage and Gene Induction

1991 • 325 citations

Liver mitochondrial respiratory functions decline with age

1989 • 322 citations

Marked Changes in Mitochondrial DNA Deletion Levels in Alzheimer Brains

1994 • 307 citations

Distribution of wild-type and common deletion forms of mtDNA in normal and respiration-deficient muscle fibers from patients with mitochondrial myopathy

1994 • 298 citations

Alterations of Antioxidant Enzymes and Oxidative Damage to Macromolecules in Different Organs of Rats During Aging

1998 • 298 citations

Marked replicative advantage of human mtDNA carrying a point mutation that causes the MELAS encephalomyopathy.

1992 • 298 citations

High frequency of homoplasmic mitochondrial DNA mutations in human tumors can be explained without selection

2001 • 292 citations

Hydrogen peroxide release by mitochondria increases during aging

1991 • 292 citations

Role of mitochondrial DNA mutations in human aging: Implications for the central nervous system and muscle

1998 • 285 citations

Age-associated oxygen damage and mutations in mitochondrial DNA in human hearts

1992 • 284 citations

Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: An age-related alteration

1990 • 276 citations

Marked increase in the number and variety of mitochondrial DNA rearrangements in aging human skeletal muscle

1995 • 276 citations

Threshold Effect and Tissue Specificity

1999 • 275 citations

Cytochrome-c-oxidase deficient cardiomyocytes in the human heart--an age-related phenomenon. A histochemical ultracytochemical study.

1989 • 275 citations

Age-Related Changes in Activities of Mitochondrial Electron Transport Complexes in Various Tissues of the Mouse

2000 • 270 citations

Age‐Dependent Impairment of Mitochondrial Function in Primate Brain

1993 • 265 citations

Differential accumulations of 4,977 bp deletion in mitochondrial DNA of various tissues in human ageing

1994 • 253 citations

The structure of human mitochondrial DNA variation

1991 • 243 citations

Accumulation of deletions in human mitochondrial DNA during normal aging: analysis by quantitative PCR

1992 • 237 citations

Mitochondrial superoxide and hydrogen peroxide generation, protein oxidative damage, and longevity in different species of flies

1995 • 234 citations

Age-associated accumulation of 8-hydroxydeoxyguanosine in mitochondrial DNA of human diaphragm

1991 • 203 citations

Relaxed Replication of mtDNA: A Model with Implications for the Expression of Disease

1999 • 199 citations

Age-related changes in antioxidant enzymes and prooxidant generation in tissues of the rat with special reference to parameters in two insect species

1990 • 193 citations

Mitochondrial Deoxyribonucleic Acid 4977-bp Deletion is Associated with Diminished Fertility and Motility of Human Sperm1

1995 • 190 citations

Methods of microphotometric assay of succinate dehydrogenase and cytochromec oxidase activities for use on human skeletal muscle

1989 • 187 citations

Oxidative damage elicited by imbalance of free radical scavenging enzymes is associated with large-scale mtDNA deletions in aging human skin

1999 • 181 citations

Mitochondrial mutational spectra in human cells and tissues

1997 • 181 citations

Effect of age on superoxide dismutase, catalase, glutathione reductase, inorganic peroxides, TBA-reactive material, GSH/GSSG, NADPH/NADP+ and NADH/NAD+ in Drosophila melanogaster

1990 • 180 citations

The COQ7 Gene Encodes a Protein in Saccharomyces cerevisiae Necessary for Ubiquinone Biosynthesis

1996 • 180 citations

Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions

1999 • 176 citations

Different in situ hybridization patterns of mitochondrial DNA in cytochrome c oxidase-deficient extraocular muscle fibres in the elderly

1993 • 171 citations

Mitochondrial gene mutation: the ageing process and degenerative diseases.

1990 • 166 citations

Mitochondrial respiratory chain activity in the human brain as a function of age

1999 • 154 citations

Late‐onset mitochondrial myopathy

1995 • 148 citations

Enhanced Mitochondrial DNA Repair and Cellular Survival after Oxidative Stress by Targeting the Human 8-Oxoguanine Glycosylase Repair Enzyme to Mitochondria

2000 • 142 citations

The point mutation of mitochondrial DNA characteristic for MERRF disease is found also in healthy people of different ages

1993 • 142 citations

Mitochondrial DNA and disease

1999 • 139 citations

Occurrence of a Particular Base Substitution (3243 A to G) in Mitochondrial DNA of Tissues of Ageing Humans

1993 • 134 citations

Effects of physical activity and age on mitochondrial function

1996 • 134 citations

Complementation and segregation behavior of disease-causing mitochondrial DNA mutations in cellular model systems

1995 • 132 citations

Cytochrome c oxidase deficient cells accumulate in the hippocampus and choroid plexus with age

2001 • 129 citations

Human Mitochondrial Diseases: Answering Questions and Questioning Answers

1998 • 123 citations

Correlation Between Mitochondrial DNA 4977-bp Deletion and Respiratory Chain Enzyme Activities in Aging Human Skeletal Muscles

1994 • 115 citations

Age-related changes in the activity of the pyruvate carrier and in the lipid composition in rat-heart mitochondria

1990 • 112 citations

Progressive loss of cytochrome c oxidase in the human extraocular muscles in ageing — a cytochemical-immunohistochemical study

1992 • 111 citations

Expression of supreoxide dismutase and catalase in rat brain as a function of age

1991 • 111 citations

Clinical features, investigation, and management of patients with defects of mitochondrial DNA

1997 • 107 citations

Mitochondrial redox signaling during apoptosis.

1999 • 107 citations

Mitochondrial DNA rearrangements in aging human brain and in situ PCR of mtDNA

1999 • 101 citations

Respiratory chain and mitochondrial DNA in muscle and brain in Parkinson's disease patients

1993 • 98 citations

Mitochondrial events in the life and death of animal cells: a brief overview.

1999 • 94 citations

Human Skin Mitochondrial DNA Deletions Associated with Light Exposure

1994 • 92 citations

Clonal expansion of mitochondrial DNA with multiple deletions in autosomal dominant progressive external ophthalmoplegia

1996 • 92 citations

A specific 4977-bp deletion of mitochondrial DNA in human ageing skin

1994 • 88 citations

Mitochondrial abnormalities in ageing macular photoreceptors.

2001 • 86 citations

Mouse models of mitochondrial disease, oxidative stress, and senescence

1999 • 84 citations

Lipid Composition in Synaptic and Nonsynaptic Mitochondria from Rat Brains and Effect of Aging

1992 • 74 citations

Accumulation of mitochondrial DNA deletions in human retina during aging.

1996 • 73 citations

Rapid Accumulation of Deleted Mitochondrial Deoxyribonucleic Acid in Postmenopausal Ovaries

1993 • 71 citations

Replicative Advantage and Tissue-Specific Segregation of RR Mitochondrial DNA Between C57BL/6 and RR Heteroplasmic Mice

2000 • 65 citations

Altered mitochondrial membrane fluidity in AD brain

1996 • 55 citations

Age-dependent structural changes in the myocardium of rats. A quantitative light- and electron-microscopic study on the right and left chamber wall

1984 • 51 citations

Isolation and Sequencing of the RatCoq7Gene and the Mapping of MouseCoq7to Chromosome 7

1996 • 48 citations

Hypoxemia is associated with mitochondrial DNA damage and gene induction. Implications for cardiac disease

1991 • 46 citations

Neuropathological and Histochemical Changes in a Multiple Mitochondrial DNA Deletion Disorder

2000 • 44 citations

Respiratory chain failure in adult muscle fibres: relationship with ageing and possible implications for the neuronal pool

1992 • 40 citations

Mitochondria Harbouring Mutant mtDNA a Cuckoo in the Nest?

1999 • 35 citations

Ocular histopathologic study of a patient with the T 8993-G point mutation in Leigh's syndrome

2000 • 33 citations

Peroxide production and apoptosis in cultured cells carrying mtDNA mutation causing encephalomyopathy

1998 • 31 citations

MERRF: a model disease for understanding the principles of mitochondrial genetics.

1991 • 23 citations

Mitochondrial DNA Mutations in Disease and Ageing

2001 • 18 citations

Focal cytochrome c oxidase deficiency in the brain and dorsal root ganglia in a case with mitochondrial encephalomyopathy (tRNAIle 4269 mutation): histochemical, immunohistochemical, and ultrastructural study

1995 • 18 citations

Quantitative changes in mitochondria of spinal ganglion neurons in aged rabbits

2001 • 17 citations