Cytochrome c oxidase deficient cells accumulate in the hippocampus and choroid plexus with age

Mitochondria and Apoptosis

1998 • 8,909 citations

The Biologic Clock: The Mitochondria?

1972 • 1,912 citations

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

1988 • 1,709 citations

Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease

1994 • 1,213 citations

MITOCHONDRIAL DNA MUTATIONS AS AN IMPORTANT CONTRIBUTOR TO AGEING AND DEGENERATIVE DISEASES

1989 • 1,179 citations

NONDROPLET ULTRASTRUCTURAL DEMONSTRATION OF CYTOCHROME OXIDASE ACTIVITY WITH A POLYMERIZING OSMIOPHILIC REAGENT, DIAMINOBENZIDINE (DAB)

1968 • 892 citations

Regionally specific loss of neurons in the aging human hippocampus

1993 • 612 citations

Volume and number of neurons of the human hippocampal formation in normal aging and Alzheimer's disease

1997 • 505 citations

Mammalian mitochondrial genetics: heredity, heteroplasmy and disease

1997 • 469 citations

Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence

1990 • 345 citations

Analyses of mitochondrial respiratory chain function and mitochondrial DNA deletion in human skeletal muscle: Effect of ageing

1992 • 329 citations

Mitochondrial enzyme activity in amyotrophic lateral sclerosis: Implications for the role of mitochondria in neuronal cell death

1999 • 324 citations

Mitochondrial angiopathy in cerebral blood vessels of mitochondrial eneephalomyopathy

1987 • 301 citations

Distribution of wild-type and common deletion forms of mtDNA in normal and respiration-deficient muscle fibers from patients with mitochondrial myopathy

1994 • 298 citations

Choroid Plexus in the Central Nervous System: Biology and Physiopathology

2000 • 287 citations

Role of mitochondrial DNA mutations in human aging: Implications for the central nervous system and muscle

1998 • 285 citations

Age-associated oxygen damage and mutations in mitochondrial DNA in human hearts

1992 • 284 citations

Differential accumulations of 4,977 bp deletion in mitochondrial DNA of various tissues in human ageing

1994 • 253 citations

Accumulation of deletions in human mitochondrial DNA during normal aging: analysis by quantitative PCR

1992 • 237 citations

Age-associated accumulation of 8-hydroxydeoxyguanosine in mitochondrial DNA of human diaphragm

1991 • 203 citations

Methods of microphotometric assay of succinate dehydrogenase and cytochromec oxidase activities for use on human skeletal muscle

1989 • 187 citations

Mitochondrial involvement in Alzheimer’s disease

1999 • 169 citations

BARRIER MECHANISMS IN THE BRAIN, I. ADULT BRAIN

1999 • 158 citations

Mitochondrial DNA and disease

1999 • 139 citations

Cytochrome oxidase in Alzheimer's disease: Biochemical, histochemical, and immunohistochemical analyses of the visual and other systems

1997 • 120 citations

Brain Protein Kinase PK40erk Converts TAU into a PHF-like Form as Found in Alzheimer′s Disease

1993 • 113 citations

Functional Alterations in Alzheimer's Disease: Selective Loss of Mitochondrial-encoded Cytochrome Oxidase mRNA in the Hippocampal Formation

1994 • 107 citations

Mitochondrial DNA rearrangements in aging human brain and in situ PCR of mtDNA

1999 • 101 citations

Respiratory chain and mitochondrial DNA in muscle and brain in Parkinson's disease patients

1993 • 98 citations

Biondi ring tangles in the choroid plexus of Alzheimer's disease and normal aging brains: a quantitative study

1999 • 85 citations

Cytochrome c oxidase defects of the human substantia nigra in normal aging

1996 • 72 citations

Curly Fiber and Tangle-like Inclusions in the Ependyma and Choroid Plexus–A Pathogenetic Relationship with the Cortical Alzheimer-type Changes?

1998 • 67 citations

Neuropathological and Histochemical Changes in a Multiple Mitochondrial DNA Deletion Disorder

2000 • 44 citations

Involvement of choroid plexus in mitochondrial encephalomyopathy (MELAS)

1987 • 39 citations

Intracellular neurofibrillary tangle-like aggregations. A constantly present amyloid alteration in the aging choroid plexus.

1986 • 36 citations

Oncocytic transformation of choroid plexus epithelium

1983 • 32 citations

Mitochondrial Genome Lesions in the Pathogenesis of Sporadic Alzheimer’s Disease

1999 • 20 citations

Focal cytochrome c oxidase deficiency in the brain and dorsal root ganglia in a case with mitochondrial encephalomyopathy (tRNAIle 4269 mutation): histochemical, immunohistochemical, and ultrastructural study

1995 • 18 citations

Deleted Work

1955 • 0 citations