Role of mitochondrial DNA mutations in human aging: Implications for the central nervous system and muscle

Oxidative damage and mitochondrial decay in aging.

1994 • 2,024 citations

The Biologic Clock: The Mitochondria?

1972 • 1,912 citations

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

1988 • 1,709 citations

Aging, energy, and oxidative stress in neurodegenerative diseases

1995 • 1,453 citations

Mitochondrial Genetics: A Paradigm for Aging and Degenerative Diseases?

1992 • 1,268 citations

MITOCHONDRIAL DNA MUTATIONS AS AN IMPORTANT CONTRIBUTOR TO AGEING AND DEGENERATIVE DISEASES

1989 • 1,179 citations

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

1994 • 1,020 citations

Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

1992 • 878 citations

Detection of a specific mitochondrial DNA deletion in tissues of older humans

1990 • 784 citations

DECLINE IN SKELETAL MUSCLE MITOCHONDRIAL RESPIRATORY CHAIN FUNCTION: POSSIBLE FACTOR IN AGEING

1989 • 722 citations

The Absence of a Pyrimidine Dimer Repair Mechanism in Mammalian Mitochondria

1974 • 517 citations

MELAS mutation in mtDNA binding site for transcription termination factor causes defects in protein synthesis and in respiration but no change in levels of upstream and downstream mature transcripts.

1992 • 490 citations

Bioenergetic and oxidative stress in neurodegenerative diseases

1995 • 365 citations

Distribution and threshold expression of the tRNA(Lys) mutation in skeletal muscle of patients with myoclonic epilepsy and ragged-red fibers (MERRF).

1992 • 330 citations

Analyses of mitochondrial respiratory chain function and mitochondrial DNA deletion in human skeletal muscle: Effect of ageing

1992 • 329 citations

Decline with age of the respiratory chain activity in human skeletal muscle

1994 • 325 citations

Hypoxemia Is Associated With Mitochondrial DNA Damage and Gene Induction

1991 • 325 citations

Distribution of wild-type and common deletion forms of mtDNA in normal and respiration-deficient muscle fibers from patients with mitochondrial myopathy

1994 • 298 citations

Marked replicative advantage of human mtDNA carrying a point mutation that causes the MELAS encephalomyopathy.

1992 • 298 citations

Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: An age-related alteration

1990 • 276 citations

Marked increase in the number and variety of mitochondrial DNA rearrangements in aging human skeletal muscle

1995 • 276 citations

Is Cell Aging Caused by Respiration-Dependent Injury to the Mitochondrial Genome?

1982 • 242 citations

Accumulation of deletions in human mitochondrial DNA during normal aging: analysis by quantitative PCR

1992 • 237 citations

Multiple mitochondrial DNA deletions in an elderly human individual

1992 • 214 citations

Quantitative determination of deleted mitochondrial DNA relative to normal DNA in parkinsonian striatum by a kinetic PCR analysis

1990 • 188 citations

Late‐onset mitochondrial myopathy

1995 • 148 citations

Effects of physical activity and age on mitochondrial function

1996 • 134 citations

Mitochondrial DNA Deletions in Muscle Fibers in Inclusion Body Myositis

1995 • 115 citations

Marked increase in mitochondrial DNA deletion levels in the cerebral cortex of Huntington's disease patients

1995 • 109 citations

Aging-dependent Functional Alterations of Mitochondrial DNA (mtDNA) from Human Fibroblasts Transferred into mtDNA-less Cells

1996 • 90 citations

Age-related human mtDNA deletions: a heterogeneous set of deletions arising at a single pair of directly repeated sequences.

1994 • 76 citations

SOME IMPORTANT PRINCIPLES IN 3,3'-DIAMINOBENZIDINE ULTRASTRUCTURAL CYTOCHEMISTRY

1973 • 70 citations

Cytochrome c oxidase activity in single muscle fibers: Assay techniques and diagnostic applications

1993 • 49 citations

BLOOD-LEAD LEVELS, BEHAVIOUR, AND INTELLIGENCE

1974 • 36 citations

Deleted Work

1955 • 0 citations