HLA DR-DQ Haplotypes and Genotypes and Type 1 Diabetes Risk

HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

1987 • 2,045 citations

HLA and Disease 1982 ‐ A Survey

1983 • 551 citations

Assessing the role of HLA-linked and unlinked determinants of disease.

1987 • 548 citations

MHC Class-II Molecules and Autoimmunity

1991 • 521 citations

The role of HLA class II genes in insulin-dependent diabetes mellitus: molecular analysis of 180 Caucasian, multiplex families.

1996 • 468 citations

Allelic sequence variation of the HLA-DQ loci: relationship to serology and to insulin-dependent diabetes susceptibility.

1988 • 378 citations

Mapping disease genes: family-based association studies.

1995 • 345 citations

Susceptibility to type I diabetes: HLA-DQ and DR revisited

1996 • 324 citations

Invited anniversary review: HLA associated diseases

1997 • 278 citations

A diabetes-susceptible HLA haplotype is best defined by a combination of HLA-DR and -DQ alleles.

1989 • 260 citations

Type 1 Diabetes

2005 • 251 citations

Absolute Risk of Childhood-Onset Type 1 Diabetes Defined by Human Leukocyte Antigen Class II Genotype: A Population-Based Study in the United Kingdom

2004 • 235 citations

HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease

2006 • 204 citations

Common and Well-Documented HLA Alleles

2007 • 202 citations

Relative predispositional effects (RPEs) of marker alleles with disease: HLA-DR alleles and Graves disease.

1989 • 193 citations

HLA class II alleles and susceptibility and resistance to insulin dependent diabetes mellitus in Mexican-American families

1993 • 186 citations

Relative predispositional effects of HLA class II DRB1‐DQB1 haplotypes and genotypes on type 1 diabetes: a meta‐analysis

2007 • 186 citations

The Predisposition to Type 1 Diabetes Linked to the Human Leukocyte Antigen Complex Includes at Least One Non–Class II Gene

1999 • 177 citations

Transcomplementation of HLA Genes in IDDM: HLA-DQ α and β-Chains Produce Hybrid Molecules in DR3/4 Heterozygotes

1987 • 158 citations

The Type 1 Diabetes Genetics Consortium

2006 • 146 citations

Genetic analysis of HLA class II alleles and susceptibility to Type 1 (insulin-dependent) diabetes mellitus in Japanese subjects

1992 • 128 citations

The HLA class I A locus affects susceptibility to type 1 diabetes

2002 • 126 citations

Combinations of specific DRB1, DQA1, DQB1 haplotypes are associated with insulin-dependent diabetes mellitus in sardinia

1993 • 120 citations

Human leukocyte antigen class I B and C loci contribute to Type 1 Diabetes (T1D) susceptibility and age at T1D onset

2005 • 119 citations

HLA-DQ allelic polymorphisms constrain patterns of class II heterodimer formation.

1993 • 110 citations

Genotype effects and epistasis in type 1 diabetes and HLA-DQ trans dimer associations with disease

2004 • 107 citations

HLA Genotypic Study of Insulin-dependent Diabetes: The Excess of DR3/DR4 Heterozygotes Allows Rejection of the Recessive Hypothesis

1983 • 97 citations

HLA-DQ molecules form alpha-beta heterodimers of mixed allotype.

1988 • 94 citations

Concannon P, Erlich HA, Julier C, Morahan G, Nerup J, Pociot F, Todd JA, Rich SS and the Type 1 Diabetes Genetics Consortium. Type 1 Diabetes: Evidence for Susceptibility Loci from Four Genome-Wide Linkage Scans in 1,435 Multiplex Families.

2005 • 88 citations

The association of specific HLA class I and II alleles with type 1 diabetes among Filipinos

2002 • 74 citations

Evidence of at least two type 1 diabetes susceptibility genes in the HLA complex distinct from HLA-DQB1, -DQA1 and –DRB1

2003 • 72 citations

The HLA-DPB1–Associated Component of the IDDM1 and Its Relationship to the Major Loci HLA-DQB1, -DQA1, and -DRB1

2001 • 70 citations

Non-class II HLA gene associated with type 1 diabetes maps to the 240-kb region near HLA-B.

2000 • 70 citations

HLA-DQβ Sequence Polymorphism and Genetic Susceptibility to IDDM

1990 • 70 citations

The modes of inheritance of insulin-dependent diabetes mellitus or the genetics of IDDM, no longer a nightmare but still a headache.

1981 • 66 citations

Association of HLA-DPB1*0301 With IDDM in Mexican-Americans

1996 • 63 citations

Conserved extended haplotypes discriminate HLA-DR3-homozygous Basque patients with type 1 diabetes mellitus and celiac disease

2006 • 58 citations

Homozygous parent affected sib pair method for detecting disease predisposing variants: Application to insulin dependent diabetes mellitus

1993 • 54 citations

DPB1 Alleles Are Associated With Type 1 Diabetes Susceptibility in Multiple Ethnic Groups

2004 • 50 citations

Particular HLA-DQ αβ Heterodimer Associated With IDDM Susceptibility in Both DR4-DQw4 Japanese and DR4-DQw8/DRw8-DQw4 Whites

1991 • 47 citations

Newborn HLA-DR,DQ genotype screening: age- and ethnicity-specific type 1 diabetes risk estimates

2005 • 44 citations

Association of insulin-dependent diabetes mellitus in Taiwan with HLA class II DQB1 and DRB1 alleles

1993 • 42 citations

Modeling of HLA class II susceptibility to Type I diabetes reveals an effect associated with DPB1

2001 • 34 citations

Linkage Disequilibrium With Predisposing DR3 Haplotypes Accounts for Apparent Effects of Tumor Necrosis Factor and Lymphotoxin-α Polymorphisms on Type 1 Diabetes Susceptibility

2006 • 34 citations

Extended DR3‐D6S273‐HLA‐B haplotypes are associated with increased susceptibility to type 1 diabetes in US Caucasians

2005 • 33 citations

HLA Class II Alleles in Amerindian Populations: Implications for the Evolution of HLA Polymorphism and the Colonization of the Americas

2004 • 29 citations

D6S265*15 marks a DRB1*15, DQB1*0602 haplotype associated with attenuated protection from type 1 diabetes mellitus

2005 • 24 citations

Transcomplementation of HLA DQA1-DQB1 in DR3/DR4 and DR3/DR9 Heterozygotes and IDDM in Taiwanese Families

1995 • 23 citations

Particular HLA-DQ alpha beta heterodimer associated with IDDM susceptibility in both DR4-DQw4 Japanese and DR4-DQw8/DRw8-DQw4 whites

1991 • 20 citations

Impaired binding of a DQ2 and DQ8‐binding HSV VP16 peptide to a DQA1*0501/DQB1*0302 trans class II heterodimer

1999 • 14 citations