Disulfide Bond Engineering to Trap Peptides in the MHC Class I Binding Groove

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

Licensing of natural killer cells by host major histocompatibility complex class I molecules

2005 • 1,256 citations

Empty MHC class I molecules come out in the cold

1990 • 933 citations

IMMUNODOMINANCE IN MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I–RESTRICTED T LYMPHOCYTE RESPONSES

1999 • 923 citations

Isolation of an endogenously processed immunodominant viral peptide from the class I H–2Kb molecule

1990 • 689 citations

Localization, Quantitation, and In Situ Detection of Specific Peptide–MHC Class I Complexes Using a Monoclonal Antibody

1997 • 679 citations

Structure of the p53 Tumor Suppressor Bound to the Ankyrin and SH3 Domains of 53BP2

1996 • 569 citations

The Repertoire of T Cells Shaped by a Single MHC/Peptide Ligand

1996 • 417 citations

Detection of rare antigen-presenting cells by the lacZ T-cell activation assay suggests an expression cloning strategy for T-cell antigens.

1992 • 407 citations

Interaction of the Thiol-Dependent Reductase ERp57 with Nascent Glycoproteins

1997 • 387 citations

Structures of an MHC Class II Molecule with Covalently Bound Single Peptides

1996 • 369 citations

T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand

2005 • 349 citations

A pentapeptide as minimal antigenic determinant for MHC class I-restricted T lymphocytes

1989 • 339 citations

Glycoproteins form mixed disulphides with oxidoreductases during folding in living cells

1999 • 317 citations

How the T Cell Repertoire Becomes Peptide and MHC Specific

2005 • 310 citations

Production of soluble MHC class II proteins with covalently bound single peptides

1994 • 302 citations

In vitroevolution of a T cell receptor with high affinity for peptide/MHC

2000 • 288 citations

A naturally occurring peptide recognized by alloreactive CD8+ cytotoxic T lymphocytes in association with a class I MHC protein

1992 • 286 citations

Crystal structure of an H-2Kb-ovalbumin peptide complex reveals the interplay of primary and secondary anchor positions in the major histocompatibility complex binding groove.

1995 • 254 citations

Kinetics and affinity of reactions between an antigen-specific T cell receptor and peptide-MHC complexes

1994 • 253 citations

Induction of ovalbumin-specific cytotoxic T cells by in vivo peptide immunization.

1989 • 220 citations

TCRs with high affinity for foreign pMHC show self-reactivity

2002 • 217 citations

Determinant selection of major histocompatibility complex class I-restricted antigenic peptides is explained by class I-peptide affinity and is strongly influenced by nondominant anchor residues.

1994 • 216 citations

Self-MHC-restricted peptides recognized by an alloreactive T lymphocyte clone.

1996 • 205 citations

High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins.

1994 • 200 citations

Localization of allodeterminants on H-2Kb antigens determined with monoclonal antibodies and H-2 mutant mice.

1982 • 194 citations

Derivation of a T cell hybridoma variant deprived of functional T cell receptor α and β chain transcripts reveals a nonfunctional α‐mRNA of BW5147 origin

1989 • 188 citations

Tapasin enhances MHC class I peptide presentation according to peptide half-life

2004 • 172 citations

A virus-specific CD8⁺T cell immunodominance hierarchy determined by antigen dose and precursor frequencies

2006 • 170 citations

Identification of Db- and Kb-Restricted Subdominant Cytotoxic T-Cell Responses in Lymphocytic Choriomeningitis Virus-Infected Mice

1998 • 164 citations

Peptide ligand-induced conformation and surface expression of the Ld class I MHC molecule

1990 • 155 citations

Requirement for Diverse, Low-Abundance Peptides in Positive Selection of T Cells

1999 • 151 citations

Variations in the number of peptide-MHC class I complexes required to activate cytotoxic T cell responses.

1995 • 148 citations

Protective cellular immunity: cytotoxic T-lymphocyte responses against dominant and recessive epitopes of influenza virus nucleoprotein induced by DNA immunization

1997 • 132 citations

A ubiquitous protein is the source of naturally occurring peptides that are recognized by a CD8+ T-cell clone.

1993 • 129 citations

Virus Subversion of the MHC Class I Peptide-Loading Complex

2003 • 125 citations

The specific binding of peptide ligand to Ld class I major histocompatibility complex molecules determines their antigenic structure.

1991 • 122 citations

Cutting Edge: Single-Chain Trimers of MHC Class I Molecules Form Stable Structures That Potently Stimulate Antigen-Specific T Cells and B Cells

2002 • 119 citations

Development of a DNA Vaccine Targeting Human Papillomavirus Type 16 Oncoprotein E6

2004 • 118 citations

Structural and Functional Consequences of Altering a Peptide MHC Anchor Residue

2001 • 108 citations

The law of mass action governs antigen-stimulated cytolytic activity of CD8+ cytotoxic T lymphocytes.

1995 • 106 citations

Cd8− T Cell Transfectants That Express a High Affinity T Cell Receptor Exhibit Enhanced Peptide-Dependent Activation

2001 • 98 citations

Model for the in vivo assembly of nascent Ld class I molecules and for the expression of unfolded Ld molecules at the cell surface.

1993 • 97 citations

Immunodominance in TCD8+ Responses to Viruses

2004 • 85 citations

The three-dimensional structure of an H-2L^d-peptide complex explains the unique interaction of L^dwith beta-2 microglobulin and peptide

1997 • 83 citations

Biology of simian virus 40 (SV40) transplantation antigen (TrAg)

1979 • 82 citations

Cancer immunotherapy using a DNA vaccine encoding a single-chain trimer of MHC class I linked to an HPV-16 E6 immunodominant CTL epitope

2005 • 77 citations

Biology of simian virus 40 (SV40) transplantation antigen (TrAg)

1977 • 74 citations

Quantitation of peptide anchor residue contributions to class I major histocompatibility complex molecule binding.

1993 • 70 citations

Slower processing, weaker beta 2-M association, and lower surface expression of H-2Ld are influenced by its amino terminus.

1986 • 69 citations

Enhanced Immune Presentation of a Single-chain Major Histocompatibility Complex Class I Molecule Engineered to Optimize Linkage of a C-terminally Extended Peptide

2003 • 60 citations

Induction of CD8+ T Cell Responses to Dominant and Subdominant Epitopes and Protective Immunity to Sendai Virus Infection by DNA Vaccination

1998 • 60 citations

Kb, Kd, and Ld Molecules Share Common Tapasin Dependencies as Determined Using a Novel Epitope Tag

2000 • 59 citations

Definition and transfer of a serological epitope specific for peptide-empty forms of MHC class I

1999 • 59 citations

A DNA vaccine encoding a single-chain trimer of HLA-A2 linked to human mesothelin peptide generates anti-tumor effects against human mesothelin-expressing tumors

2006 • 59 citations

In vivo CTL induction with point-substituted ovalbumin peptides: immunogenicity correlates with peptide-induced MHC class I stability

1995 • 53 citations

An HLA-E single chain trimer inhibits human NK cell reactivity towards porcine cells

2005 • 52 citations

Interactions of HLA-B27 with the peptide loading complex as revealed by heavy chain mutations

2001 • 50 citations

Recognition of HLA-A2-restricted mammaglobin-A-derived epitopes

2004 • 48 citations

Topology of T cell receptor-peptide/class I MHC interaction defined by charge reversal complementation and functional analysis

1997 • 41 citations

Tumor-specific Ab-mediated targeting of MHC-peptide complexes induces regression of human tumor xenograftsin vivo

2004 • 38 citations

The peptide p2Ca is immunodominant in allorecognition of Ld by beta chain variable region V beta 8+ but not V beta 8- strains.

1994 • 35 citations

Antibody-conjugated MHC class I tetramers can target tumor cells for specific lysis by T lymphocytes

2000 • 33 citations

Requirements for the Selective Degradation of Endoplasmic Reticulum-Resident Major Histocompatibility Complex Class I Proteins by the Viral Immune Evasion Molecule mK3

2005 • 32 citations

The Mode of Ligand Recognition by Two Peptide:MHC Class I-Specific Monoclonal Antibodies

1999 • 31 citations

Sensitization of tumour cells to lysis by virus-specific CTL using antibody-targeted MHC class I/peptide complexes

2000 • 28 citations

Thiol oxidation and reduction in MHC-restricted antigen processing and presentation

1999 • 22 citations

Applications of Major Histocompatibility Complex Class I Molecules Expressed as Single Chains

2005 • 21 citations

Flow Cytometry Applications of MHC Tetramers

2004 • 16 citations

Most residues on the floor of the antigen binding site of the class I MHC molecule H-2K^d influence peptide presentation

1992 • 13 citations