PLANT ALKALOID TETRANDRINE AND ITS ANALOG BLOCK CD28-COSTIMULATED ACTIVITIES OF HUMAN PERIPHERAL BLOOD T CELLS

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 • 1,212 citations

Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg

1992 • 1,156 citations

The Th1/Th2 paradigm

1997 • 1,102 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

1989 • 910 citations

Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases

1996 • 650 citations

Pharmacology and applications of chinese materia medica

1987 • 550 citations

Regulation of T Cell Receptor Signaling by Tyrosine Phosphatase SYP Association with CTLA-4

1996 • 529 citations

Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles.

1994 • 527 citations

Immunobiology of Tissue Transplantation: A Return to the Passenger Leukocyte Concept

1983 • 524 citations

Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion.

1993 • 502 citations

Chinese Drugs of Plant Origin: Chemistry, Pharmacology, and Use in Traditional and Modern Medicine

1992 • 454 citations

Co-stimulation in T cell responses

1997 • 430 citations

CTLA-4: a negative regulator of autoimmune disease.

1996 • 382 citations

IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase.

1995 • 304 citations

HEART ALLOGRAFTS IN MURINE SYSTEMS

1992 • 299 citations

IFN-gamma is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways.

1998 • 275 citations

Cytokines and the Th1/Th2 paradigm in transplantation

1994 • 243 citations

B7 but not intercellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specific tolerance.

1993 • 205 citations

Polarized type 2 alloreactive CD4+ and CD8+ donor T cells fail to induce experimental acute graft-versus-host disease.

1995 • 204 citations

The interleukin 2 CD28-responsive complex contains at least three members of the NF kappa B family: c-Rel, p50, and p65.

1993 • 201 citations

Blockade of T-cell costimulation prevents development of experimental chronic renal allograft rejection.

1996 • 170 citations

Donor CD4-enriched cells of Th2 cytokine phenotype regulate graft- versus-host disease without impairing allogeneic engraftment in sublethally irradiated mice

1994 • 159 citations

ENHANCED TYPE 2 AND DIMINISHED TYPE 1 CYTOKINES IN NEONATAL TOLERANCE

1995 • 148 citations

Unmodified pancreatic islet allograft rejection results in the preferential expression of certain T cell activation transcripts.

1993 • 136 citations

CD28 signaling causes a sustained down-regulation of I kappa B alpha which can be prevented by the immunosuppressant rapamycin.

1994 • 132 citations

RelA Is a Potent Transcriptional Activator of the CD28 Response Element within the Interleukin 2 Promoter

1995 • 131 citations

Late blockade of T cell costimulation interrupts progression of experimental chronic allograft rejection.

1998 • 129 citations

Blocking the CD28-B7 T cell costimulation pathway induces long term cardiac allograft acceptance in the absence of IL-4.

1997 • 129 citations

CTLA-4–B7 Interaction Is Sufficient to Costimulate T Cell Clonal Expansion

1997 • 120 citations

Infusion of anti-B7.1 (CD80) and anti-B7.2 (CD86) monoclonal antibodies inhibits murine graft-versus-host disease lethality in part via direct effects on CD4+ and CD8+ T cells.

1996 • 120 citations

Evidence for the involvement of three distinct signals in the induction of IL-2 gene expression in human T lymphocytes.

1989 • 117 citations

Differential effect of CTLA4Ig on murine graft-versus-host disease (GVHD) development: CTLA4Ig prevents both acute and chronic GVHD development but reverses only chronic GVHD.

1996 • 91 citations

Effect of CD28 signal transduction on c-Rel in human peripheral blood T cells.

1994 • 89 citations

Effect of (-)-epigallocatechin gallate on leukemic blast cells from patients with acute myeloblastic leukemia

1996 • 78 citations

Interleukin-12 Inhibits Graft-Versus-Host Disease Through an Fas-Mediated Mechanism Associated With Alterations in Donor T-Cell Activation and Expansion

1998 • 76 citations

In vitro inhibition of proliferation of HL-60 cells by tetrandrine and coriolus versicolor peptide derived from Chinese medicinal herbs

1997 • 74 citations

The effects of traditional antirheumatic herbal medicines on immune response cells.

1997 • 72 citations

Cytokine Mrna Profiles In Mouse Orthotopic Liver Transplantation Graft Rejectionis Associasted With Augmented Th1 Function

1995 • 70 citations

Corticosteroids class-dependently inhibit in vitro Th1- and Th2-type cytokine production

1995 • 68 citations

CD28-costimulation activates cyclic AMP-responsive element-binding protein in T lymphocytes.

1997 • 57 citations

Cytotoxicity to macrophages of tetrandrine, an antisilicosis alkaloid, accompanied by an overproduction of prostaglandins

1997 • 54 citations

Activation of Nuclear Factor of Activated T Cells in a Cyclosporin A-resistant Pathway

1996 • 50 citations

CD28-B7 T cell costimulatory blockade by CTLA4Ig in sensitized rat recipients: induction of transplantation tolerance in association with depressed cell-mediated and humoral immune responses.

1997 • 49 citations

Mechanism of immunosuppression of the antirheumatic herb TWHf in human T cells.

1999 • 47 citations

Tetrandrine, a plant alkaloid, inhibits the production of tumour necrosis factor-alpha (cachectin) hy human monocytes

1990 • 45 citations

In vitro Immunosuppressive Properties of the Plant Alkaloid Tetrandrine

1988 • 43 citations

Comparative effects of tetrandrine and berbamine on subcutaneous air pouch inflammation induced by interleukin-1, tumour necrosis factor and platelet-activating factor

1992 • 38 citations

Anti-inflammatory activity of the isoquinoline alkaloid, tetrandrine, against established adjuvant arthritis in rats

1994 • 38 citations

Inhibition of Proliferative Activity of Pulmonary Fibroblasts by Tetrandrine

1993 • 36 citations

CD28-mediated cytotoxicity by the human leukemic NK cell line YT involves tyrosine phosphorylation, activation of phosphatidylinositol 3-kinase, and protein kinase C.

1996 • 35 citations

EXPRESSION OF ADHESION MOLECULES IN ALLOGRAFT RENAL DYSFUNCTION

1993 • 34 citations

Plant alkaloid tetrandrine downregulates protein kinase C-dependent signaling pathway in T cells

1999 • 34 citations

Dauricoside, a New Glycosidal Alkaloid Having an Inhibitory Activity against Blood-Platelet Aggregation.

1993 • 33 citations

Inhibition of Histamine Release from Rat Mast Cells by the Plant Alkaloid Tetrandrine

1988 • 30 citations

COEXISTENCE OF TH1- AND TH2-TYPE CYTOKINE PROFILES IN ANTI-CD2 MONOCLONAL ANTIBODY-INDUCED TOLERANCE1

1996 • 28 citations

Effect of berbamine on T-cell mediated immunity and the prevention of rejection on skin transplants in mice

1998 • 27 citations

Alterations in Alveolar Type II Cell Metabolism Induced by Tetrandrine and Other Alkaloids

1993 • 16 citations

T-CELL ALTERATIONS IN CARDIAC ALLOGRAFT RECIPIENTS AFTER B7 (CD80 AND CD86) BLOCKADE1

1998 • 15 citations

NEONATAL TRANSPLANTATION TOLERANCE IS ASSOCIATED WITH A SYSTEMIC REDUCTION IN MEMORY CELLS, ALTERED CHIMERIC CELL PHENOTYPE, AND MODIFIED EICOSANOID AND CYTOKINE PRODUCTION1

1996 • 10 citations

The Effects of Dauricine and Verapamil as Calcium Channel Blockers on the Plasma Concentration of 6-Keto-Prostaglandin F_1αand Thromboxane B₂during Cardiopulmonary Bypass

1987 • 5 citations