IFN-gamma is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways.

CELLULAR RESPONSES TO INTERFERON-γ

1997 • 2,885 citations

Heart-Lung Transplantation

2016 • 2,165 citations

Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes

1993 • 1,753 citations

A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Heart Rejection Study Group. The International Society for Heart Transplantation.

1990 • 1,515 citations

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

1996 • 1,457 citations

Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE).

1996 • 985 citations

Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones.

1988 • 845 citations

Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule

1992 • 820 citations

A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells.

1992 • 818 citations

PRIMARILY VASCULARIZED ALLOGRAFTS OF HEARTS IN MICE

1973 • 801 citations

IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis.

1996 • 642 citations

CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2.

1995 • 532 citations

Accelerated collagen-induced arthritis in IFN-gamma receptor-deficient mice.

1997 • 465 citations

Interferon-γ: Biology and Role in Pathogenesis

1996 • 433 citations

Nitric oxide production is required for murine resident peritoneal macrophages to suppress mitogen-stimulated T cell proliferation. Role of IFN-gamma in the induction of the nitric oxide-synthesizing pathway.

1991 • 384 citations

Interferon gamma plays a critical role in induced cell death of effector T cell: a possible third mechanism of self-tolerance.

1990 • 372 citations

High susceptibility to collagen-induced arthritis in mice lacking IFN-gamma receptors.

1997 • 361 citations

Macrophage-mediated suppression. I. Evidence for participation of both hdyrogen peroxide and prostaglandins in suppression of murine lymphocyte proliferation.

1980 • 345 citations

Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood T cells.

1993 • 341 citations

TRANSPLANTATION TOLERANCE INDUCED BY CTLA4-Ig1

1994 • 303 citations

HEART ALLOGRAFTS IN MURINE SYSTEMS

1992 • 299 citations

Superantigens: Bacterial and Viral Proteins that Manipulate the Immune System

1993 • 236 citations

IL-2 knockout recipient mice reject islet cell allografts.

1995 • 204 citations

Religation of the T cell receptor after primary activation of mature T cells inhibits proliferation and induces apoptotic cell death.

1993 • 152 citations

Effects of FK506 and cyclosporin A on cytokine production studied in vitro at a single-cell level.

1992 • 152 citations

Unmodified pancreatic islet allograft rejection results in the preferential expression of certain T cell activation transcripts.

1993 • 136 citations

Blocking the CD28-B7 T cell costimulation pathway induces long term cardiac allograft acceptance in the absence of IL-4.

1997 • 129 citations

PERIPHERAL TOLERANCE OF AN ALLOGRAFT IN ADULT RATS—CHARACTERIZATION BY LOW INTERLEUKIN-2 AND INTERFERON-γ mRNA LEVELS AND BY STRONG ACCUMULATION OF MAJOR HISTOCOMPATIBILITY COMPLEX TRANSCRIPTS IN THE GRAFT

1992 • 117 citations

PREVENTION OF TH1 RESPONSES IS CRITICAL FOR TOLERANCE1

1996 • 112 citations

ACUTE REJECTION OF VASCULARIZED HEART ALLOGRAFTS IN THE ABSENCE OF IFN??1,2

1996 • 112 citations

The in vivo mechanism of action of CTLA4Ig.

1996 • 106 citations

The relative contribution of the CD28 and gp39 costimulatory pathways in the clonal expansion and pathogenic acquisition of self-reactive T cells.

1996 • 104 citations

Induction and Measurement of Cytotoxic T Lymphocyte Activity

2018 • 85 citations

Impact of interferon-gamma receptor deficiency on experimental Staphylococcus aureus septicemia and arthritis.

1995 • 83 citations

Immunodeficiency in graft-versus-host disease. I. Mechanism of immune suppression.

1988 • 80 citations

IFN-gamma receptor-deficient mice are hypersensitive to the anti-CD3-induced cytokine release syndrome and thymocyte apoptosis. Protective role of endogenous nitric oxide.

1995 • 68 citations

Specific prolongation of MHC class II disparate skin allografts by in vivo administration of anti-IFN-gamma monoclonal antibody.

1990 • 51 citations

Sensitivity of T cells to anti‐CD3‐stimulated suicide is independent of functional phenotype

1992 • 51 citations

Involvement of IFN-gamma and transforming growth factor-beta in graft-vs-host reaction-associated immunosuppression.

1993 • 41 citations

Interferon-γ inhibits tumor antigen presentation by epidermal antigen-presenting cells

1994 • 27 citations

SYNERGISTIC IMMUNOSUPPRESSIVE EFFECTS OF MONOCLONAL ANTIBODIES SPECIFIC FOR INTERFERON-GAMMA AND TUMOR NECROSIS FACTOR ALPHA

1990 • 25 citations

Effect of recombinant interferon gamma and interleukin-2 and of a monoclonal antibody against interferon gamma on the rat immune response against heart allografts.

1991 • 23 citations