Cytotoxicity to macrophages of tetrandrine, an antisilicosis alkaloid, accompanied by an overproduction of prostaglandins

The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes.

1990 • 940 citations

Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide.

1992 • 823 citations

Prostaglandin E2 regulates macrophage-derived tumor necrosis factor gene expression.

1988 • 670 citations

Mechanism for irreversible self-deactivation of prostaglandin synthetase.

1976 • 600 citations

Evidence for a peroxide-initiated free radical mechanism of prostaglandin biosynthesis.

1980 • 481 citations

Role of secretory phospholipases A2 in the pathobiology of disease.

1986 • 382 citations

Cytotoxic and Antimalarial Bisbenzylisoquinolme Alkaloids from Stephania erecta

1993 • 253 citations

Properties and purification of an arachidonoyl-hydrolyzing phospholipase A2 from a macrophage cell line, RAW 264.7

1988 • 236 citations

Molecular determinants of Ca2+ channel function and drug action

1995 • 198 citations

Comparative antioxidant activities of propranolol, nifedipine, verapamil, and diltiazem against sarcolemmal membrane lipid peroxidation.

1990 • 164 citations

Interaction of tetrandrine with slowly inactivating calcium channels. Characterization of calcium channel modulation by an alkaloid of Chinese medicinal herb origin.

1988 • 153 citations

An 100‐kDa arachidonate‐mobilizing phospholipase A₂ in mouse spleen and the macrophage cell line J774

1991 • 136 citations

[Identification and characterization of two phospholipase A2 activities in resident mouse peritoneal macrophages.]

1981 • 118 citations

Solubilization, purification, and characterization of a membrane-bound phospholipase A2 from the P388D1 macrophage-like cell line.

1988 • 114 citations

Involvement of tyrosine kinase in the induction of cyclo‐oxygenase and nitric oxide synthase by endotoxin in cultured cells

1994 • 95 citations

Recent cardiovascular drugs from Chinese medicinal plants

1993 • 94 citations

Tetrandrine: A new ligand to block voltage-dependent Ca2+ and Ca2+-activated K+ channels

1994 • 87 citations

A phospholipase A₂ hydrolyzing arachidonoyl‐phospholipids in mouse peritonea macrophages

1989 • 84 citations

In vitro antiplasmodial, antiamoebic, and cytotoxic activities of a series of bisbenzylisoquinoline alkaloids

1994 • 80 citations

Cytotoxic and Antimalarial Bisbenzylisoquinoline Alkaloids from Cyclea barbata

1993 • 78 citations

Inhibition of cholesteryl ester deposition in macrophages by calcium entry blockers: an effect dissociable from calcium entry blockade

1987 • 68 citations

Modulation of tumor necrosis factor-alpha gene expression. Desensitization of prostaglandin E2-induced suppression.

1989 • 67 citations

Phospholipase activities of the P388D1 macrophage-like cell line

1985 • 65 citations

Inhibitory effect of bisbenzylisoquinoline alkaloids on nitric oxide production in activated macrophages

1993 • 65 citations

Mechanism of increased tumor necrosis factor production after thermal injury. Altered sensitivity to PGE2 and immunomodulation with indomethacin.

1993 • 61 citations

Bisbenzylisoquinoline Alkaloids

1987 • 59 citations

Tetrandrine Inhibits Both T and L Calcium Channel Currents in Ventricular Cells

1992 • 55 citations

Molecular manipulations of the multidrug transporter: a new role for transgenic mice ¹

1991 • 51 citations

Plant‐derived drugs acting on cellular ca ²⁺ mobilization in vascular smooth muscle: Tetramethylpyrazine and tetrandrine

1994 • 51 citations

Auranofin inhibits the induction of interleukin 1β and tumor necrosis factor α mRNA in macrophages

1995 • 49 citations

Dual Ca2+ requirement for optimal lipid peroxidation of low density lipoprotein by activated human monocytes.

1993 • 41 citations

Inhibition of Stimulant-Induced Activation of Phagocytic Cells With Tetrandrine

1991 • 40 citations

Observation of the effect of tetrandrine on experimental silicosis of rats

1983 • 37 citations

Dual effects of tetrandrine on cytosolic calcium in human leukaemic HL‐60 cells: intracellular calcium release and calcium entry blockade

1994 • 35 citations

Studies on the contents of glycosaminoglycans from lungs of silicotic rats and tetrandrine-treated silicotic rats

1983 • 33 citations

Xenobiotics and Inflammation

1994 • 29 citations

Platelet-activating factor–induced calcium mobilization and oxidative metabolism in hepatic macrophages and endothelial cells

1993 • 27 citations

The purification and molecular properties of the tryptophan-sensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Neurospora crassa

1981 • 20 citations

Effects of bisbenzylisoquinoline alkaloids on alveolar macrophages: Correlation between binding affinity, inhibitory potency, and antifibrotic potential

1991 • 17 citations

Tetrandrine delivery to the lung: The optimisation of albumin microsphere preparation by central composite design

1994 • 16 citations

Binding of Bisbenzylisoquinoline Alkaloids to Phosphatidylcholine Vesicles and Alveolar Macrophages: Relationship Between Binding Affinity and Antifibrogenic Potential of These Drugs

1991 • 15 citations

Circumvention of drug resistance with calcium channel blockers and monoclonal antibodies

1989 • 14 citations

Antirheumatic gold compounds and penicillamine enhance protein kinase C-mediated activation of the arachidonate- mobilizing phospholipase A2 in mouse macrophages

1993 • 13 citations

Effect of verapamil and nifedipine on cholesteryl ester metabolism and low-density lipoprotein oxidation in macrophages

1995 • 12 citations

Calcium influx is required for tannin-mediated arachidonic acid release from alveolar macrophages

1995 • 10 citations

The oral gold compound auranofin triggers arachidonate release and cyclooxygenase metabolism in the alveolar macrophage

1988 • 10 citations

Fibroblast growth factors mobilize peritoneal macrophage intracellular calcium

1994 • 9 citations

Pulmonary Fibrosis Induced by Silica, Asbestos, and Bleomycin

1994 • 1 citations